PMID- 37915574
OWN - NLM
STAT- MEDLINE
DCOM- 20231103
LR  - 20231105
IS  - 1664-3224 (Electronic)
IS  - 1664-3224 (Linking)
VI  - 14
DP  - 2023
TI  - Tolerogenic dendritic cells and TLR4/IRAK4/NF-kappaB signaling pathway in allergic 
      rhinitis.
PG  - 1276512
LID - 10.3389/fimmu.2023.1276512 [doi]
LID - 1276512
AB  - Dendritic cells (DCs), central participants in the allergic immune response, can 
      capture and present allergens leading to allergic inflammation in the 
      immunopathogenesis of allergic rhinitis (AR). In addition to initiating 
      antigen-specific immune responses, DCs induce tolerance and modulate immune 
      homeostasis. As a special type of DCs, tolerogenic DCs (tolDCs) achieve immune 
      tolerance mainly by suppressing effector T cell responses and inducing regulatory 
      T cells (Tregs). TolDCs suppress allergic inflammation by modulating immune 
      tolerance, thereby reducing symptoms of AR. Activation of the TLR4/IRAK4/NF-kappaB 
      signaling pathway contributes to the release of inflammatory cytokines, and 
      inhibitors of this signaling pathway induce the production of tolDCs to alleviate 
      allergic inflammatory responses. This review focuses on the relationship between 
      tolDCs and TLR4/IRAK4/NF-kappaB signaling pathway with AR.
CI  - Copyright (c) 2023 Kang, Li, Liu, Liu, Niu, Zeng, Zhao, Liu and Qiu.
FAU - Kang, Chenglin
AU  - Kang C
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, China.
AD  - Department of Otolaryngology, Longgang E.N.T Hospital and Shenzhen Key Laboratory 
      of E.N.T, Institute of E.N.T Shenzhen, Shenzhen, China.
AD  - Department of Otolaryngology, Second People's Hospital of Gansu Province, 
      Lanzhou, China.
FAU - Li, Xiaomei
AU  - Li X
AD  - Department of Otolaryngology, Second People's Hospital of Gansu Province, 
      Lanzhou, China.
FAU - Liu, Peng
AU  - Liu P
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, China.
FAU - Liu, Yue
AU  - Liu Y
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, China.
FAU - Niu, Yuan
AU  - Niu Y
AD  - Department of Neurology, Second People's Hospital of Gansu Province, Lanzhou, 
      China.
FAU - Zeng, Xianhai
AU  - Zeng X
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, China.
AD  - Department of Otolaryngology, Longgang E.N.T Hospital and Shenzhen Key Laboratory 
      of E.N.T, Institute of E.N.T Shenzhen, Shenzhen, China.
FAU - Zhao, Hailiang
AU  - Zhao H
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, China.
AD  - Department of Otolaryngology, Longgang E.N.T Hospital and Shenzhen Key Laboratory 
      of E.N.T, Institute of E.N.T Shenzhen, Shenzhen, China.
FAU - Liu, Jiangqi
AU  - Liu J
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, China.
AD  - Department of Otolaryngology, Longgang E.N.T Hospital and Shenzhen Key Laboratory 
      of E.N.T, Institute of E.N.T Shenzhen, Shenzhen, China.
FAU - Qiu, Shuqi
AU  - Qiu S
AD  - Department of Graduate and Scientific Research, Zunyi Medical University Zhuhai 
      Campus, Zhuhai, China.
AD  - Department of Otolaryngology, Longgang E.N.T Hospital and Shenzhen Key Laboratory 
      of E.N.T, Institute of E.N.T Shenzhen, Shenzhen, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20231017
PL  - Switzerland
TA  - Front Immunol
JT  - Frontiers in immunology
JID - 101560960
RN  - 0 (NF-kappa B)
RN  - 0 (Toll-Like Receptor 4)
RN  - EC 2.7.11.1 (Interleukin-1 Receptor-Associated Kinases)
RN  - 0 (TLR4 protein, human)
RN  - EC 2.7.11.1 (IRAK4 protein, human)
SB  - IM
MH  - Humans
MH  - *NF-kappa B
MH  - Toll-Like Receptor 4
MH  - Interleukin-1 Receptor-Associated Kinases
MH  - *Rhinitis, Allergic
MH  - Signal Transduction
MH  - Inflammation
MH  - Dendritic Cells
PMC - PMC10616250
OTO - NOTNLM
OT  - TLR4/IRAK4/NF-kappaB signaling pathway
OT  - allergic rhinitis
OT  - immune response
OT  - immune tolerance
OT  - tolerogenic dendritic cells
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/11/02 06:42
MHDA- 2023/11/03 06:44
PMCR- 2023/01/01
CRDT- 2023/11/02 04:02
PHST- 2023/08/12 00:00 [received]
PHST- 2023/10/05 00:00 [accepted]
PHST- 2023/11/03 06:44 [medline]
PHST- 2023/11/02 06:42 [pubmed]
PHST- 2023/11/02 04:02 [entrez]
PHST- 2023/01/01 00:00 [pmc-release]
AID - 10.3389/fimmu.2023.1276512 [doi]
PST - epublish
SO  - Front Immunol. 2023 Oct 17;14:1276512. doi: 10.3389/fimmu.2023.1276512. 
      eCollection 2023.