PMID- 37916198
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231103
IS  - 1745-0179 (Print)
IS  - 1745-0179 (Electronic)
IS  - 1745-0179 (Linking)
VI  - 19
DP  - 2023
TI  - Association between Proinflammatory Cytokines and Anxiety and Depression Symptoms 
      in Rheumatoid Arthritis Patients: A Cross-sectional Study.
PG  - e174501792304261
LID - 10.2174/17450179-v19-e230510-2022-34 [doi]
LID - e174501792304261
AB  - BACKGROUND: Rheumatoid arthritis (RA) patients have a greater prevalence of 
      anxiety and depression. Proinflammatory cytokines are elevated in RA. We aim to 
      evaluate the association between systemic inflammation in RA and anxiety and 
      depression. METHODS: There were 31 RA patients, 16 with active disease activity 
      and 15 in remission state; they were assessed using the Hospital Anxiety and 
      Depression Scale and for RA disease activity using Disease Activity Score of 28 
      joints (DAS28) - CRP (C-reactive protein). Serum proinflammatory cytokines were 
      measured, including interleukin (IL)-6, IL-17, and Tumour Necrosis Factor-alpha 
      (TNF-alpha). RESULTS: Among 31 patients, ten patients showed anxiety symptoms, 19 
      patients showed depression symptoms, and two displayed mixed symptoms. Serum 
      TNF-alpha levels were significantly higher in active disease than in the remission 
      group (p-value 0.006). There was no association or correlation between 
      proinflammatory cytokines to anxiety and depression symptoms in the active 
      disease and remission groups. CONCLUSION: This suggests that other factors 
      besides disease activity and state of systemic inflammation may cause anxiety and 
      depression in RA patients.
CI  - (c) 2023 Parlindungan et al.
FAU - Parlindungan, Faisal
AU  - Parlindungan F
AD  - Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, 
      Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, 
      Indonesia.
FAU - Hidayat, Rudy
AU  - Hidayat R
AD  - Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, 
      Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, 
      Indonesia.
FAU - Ariane, Anna
AU  - Ariane A
AD  - Department of Internal Medicine, Division of Rheumatology, Faculty of Medicine, 
      Universitas Indonesia, Dr. Cipto Mangunkusumo National General Hospital, Jakarta, 
      Indonesia.
FAU - Shatri, Hamzah
AU  - Shatri H
AD  - Department of Internal Medicine, Division of Psychosomatic and Palliative, 
      Faculty of Medicine, Universitas Indonesia, Dr. Cipto Mangunkusumo National 
      General Hospital, Jakarta, Indonesia.
LA  - eng
PT  - Journal Article
DEP - 20230622
PL  - United Arab Emirates
TA  - Clin Pract Epidemiol Ment Health
JT  - Clinical practice and epidemiology in mental health : CP & EMH
JID - 101245735
PMC - PMC10351345
OTO - NOTNLM
OT  - Anxiety
OT  - Arthritis rheumatoid
OT  - Depression
OT  - Inflammation
OT  - Interleukin-17
OT  - Interleukin-6
OT  - Tumor necrosis factor-alpha
COIS- All authors have no conflict of interest to declare.
EDAT- 2023/11/02 06:42
MHDA- 2023/11/02 06:43
PMCR- 2023/06/22
CRDT- 2023/11/02 04:15
PHST- 2022/08/25 00:00 [received]
PHST- 2023/03/20 00:00 [revised]
PHST- 2023/03/28 00:00 [accepted]
PHST- 2023/11/02 06:43 [medline]
PHST- 2023/11/02 06:42 [pubmed]
PHST- 2023/11/02 04:15 [entrez]
PHST- 2023/06/22 00:00 [pmc-release]
AID - CPEMH-19-E174501792304261 [pii]
AID - 10.2174/17450179-v19-e230510-2022-34 [doi]
PST - epublish
SO  - Clin Pract Epidemiol Ment Health. 2023 Jun 22;19:e174501792304261. doi: 
      10.2174/17450179-v19-e230510-2022-34. eCollection 2023.