PMID- 37916384
OWN - NLM
STAT- MEDLINE
DCOM- 20231103
LR  - 20231103
IS  - 2284-0729 (Electronic)
IS  - 1128-3602 (Linking)
VI  - 27
IP  - 20
DP  - 2023 Oct
TI  - Impact of COVID-19 pandemic on patients affected by peripheral arterial disease: 
      an Italian single-center study.
PG  - 10144-10155
LID - 34194 [pii]
LID - 10.26355/eurrev_202310_34194 [doi]
AB  - OBJECTIVE: Coronavirus disease 2019 (COVID-19) has evolved into a global 
      pandemic, affecting a wide range of medical and surgical specialties. During 
      COVID-19, we assisted in the reallocation of medical resources and services, as 
      well as social distancing measures, and many patients with chronic diseases and 
      comorbidities may have experienced difficulties in obtaining the correct medical 
      care. The aim of the study was to investigate the impact of the COVID-19 pandemic 
      on major adverse cardiovascular events (MACE) and major adverse limb events 
      (MALE) in patients with peripheral arterial disease (PAD) and chronic 
      limb-threatening ischemia (CLTI), compared to previous years. PATIENTS AND 
      METHODS: We evaluated 1,335 hospital admissions of 877 patients with PAD admitted 
      to Policlinico A. Gemelli Hospital between January 2017 and February 2020 and 368 
      hospital admissions of 272 patients with PAD admitted to the Policlinico A. 
      Gemelli Hospital between March 2020 and March 2021. Data on demographic 
      characteristics, comorbidities, symptoms, physical and radiological findings, 
      laboratory tests, and routine visits before or after discharge were collected 
      from electronic medical records. RESULTS: Emergency room (ER) admissions among 
      PAD patients during COVID-19 were higher than before the pandemic [190 (51.63%) 
      vs. 579 (43.37%), p = 0.01]. A MACE was found in 78 (5.84%) pre-pandemic 
      hospitalizations and 126 (34.24%) pandemic hospitalizations (p < 0.01). A MALE 
      was identified in 942 (70.56%) pre-pandemic hospitalizations and 331 (89.95%) 
      pandemic hospitalizations (p < 0.01). Amputation rates during the pandemic were 
      higher than before the pandemic [80 (21.74%) vs. 191 (14.31%), p < 0.01]. The 
      number of in-hospital deaths did not differ between the pandemic and pre-pandemic 
      periods [11 (2.99%) vs. 51 (3.82%), p = 0.55]. CONCLUSIONS: In patients with PAD 
      and CLTI, the number of MACE, MALE, and amputations was higher during the 
      COVID-19 period compared to the three years before the pandemic.
FAU - Rando, M M
AU  - Rando MM
AD  - Cardiovascular Internal Medicine Unit, Fondazione Policlinico Universitario A. 
      Gemelli IRCCS, Rome, Italy. f.biscetti@gmail.com.
FAU - Biscetti, F
AU  - Biscetti F
FAU - Masciocchi, C
AU  - Masciocchi C
FAU - Savino, M
AU  - Savino M
FAU - Nicolazzi, M A
AU  - Nicolazzi MA
FAU - Nardella, E
AU  - Nardella E
FAU - Cecchini, A L
AU  - Cecchini AL
FAU - Rossini, E
AU  - Rossini E
FAU - Massetti, M
AU  - Massetti M
FAU - Gasbarrini, A
AU  - Gasbarrini A
FAU - Flex, A
AU  - Flex A
LA  - eng
PT  - Journal Article
PL  - Italy
TA  - Eur Rev Med Pharmacol Sci
JT  - European review for medical and pharmacological sciences
JID - 9717360
SB  - IM
MH  - Humans
MH  - *COVID-19/epidemiology
MH  - Pandemics
MH  - Retrospective Studies
MH  - *Peripheral Arterial Disease/diagnosis
MH  - Hospitalization
MH  - Risk Factors
MH  - Ischemia
EDAT- 2023/11/02 06:42
MHDA- 2023/11/03 06:44
CRDT- 2023/11/02 04:43
PHST- 2023/11/03 06:44 [medline]
PHST- 2023/11/02 06:42 [pubmed]
PHST- 2023/11/02 04:43 [entrez]
AID - 34194 [pii]
AID - 10.26355/eurrev_202310_34194 [doi]
PST - ppublish
SO  - Eur Rev Med Pharmacol Sci. 2023 Oct;27(20):10144-10155. doi: 
      10.26355/eurrev_202310_34194.