PMID- 37916419 OWN - NLM STAT- MEDLINE DCOM- 20231216 LR - 20240124 IS - 1744-8360 (Electronic) IS - 1473-7175 (Linking) VI - 23 IP - 12 DP - 2023 Jul-Dec TI - Obtaining long-term recovery: advances in optimizing treatment outcomes in patients with binge-eating disorder. PG - 1097-1111 LID - 10.1080/14737175.2023.2273392 [doi] AB - INTRODUCTION: Binge-eating disorder (BED) is a complex and disabling eating disorder (ED) associated with considerable burden and impairments in quality of life and physical/mental health. It has been recognized as a formal ED category since 2013, however BED is still underdetected and undertreated. AREAS COVERED: This review summarizes the advances in the understanding of the pathophysiology of BED as well as the evidence on the efficacy of the existing treatments. The authors searched Scopus, PubMed, ClinicalTrials.Gov, and ANZCTR with terms including 'assessment' OR 'treatment' OR 'diagnosis' OR 'mechanisms' AND 'binge eating' OR 'binge-eating disorder' for manuscripts published between January 2013 and April 2023. EXPERT OPINION: Most of the trials on treatments of BED have been in people of high weight with weight loss as an outcome. Nevertheless, less is known about the treatment of this condition in people with body mass index (BMI) within the normal range where weight stabilization may be a more appropriate goal. Moreover, there is a need for an enhanced appreciation of the role of combination treatment to improve overall outcomes. Also, there are important opportunities for future research in understanding the mechanisms of action and effectiveness of BED treatments. FAU - de Moraes, Carlos Eduardo Ferreira AU - de Moraes CEF AD - Obesity and Eating Disorders Group (GOTA), Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. AD - Translational Health Research Institute, School of Medicine, Western Sydney University, Sydney, Australia. FAU - Donnelly, Brooke AU - Donnelly B AD - Clinical Psychology Unit, School of Psychology, University of Sydney, Camperdown, Australia. FAU - Appolinario, Jose Carlos AU - Appolinario JC AD - Obesity and Eating Disorders Group (GOTA), Institute of Psychiatry, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil. FAU - Hay, Phillipa AU - Hay P AD - Translational Health Research Institute, School of Medicine, Western Sydney University, Sydney, Australia. AD - Mental Health Services, South West Sydney Local Health District (SWSLHD), Campbelltown, Australia. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PT - Review DEP - 20231215 PL - England TA - Expert Rev Neurother JT - Expert review of neurotherapeutics JID - 101129944 SB - IM MH - Humans MH - *Binge-Eating Disorder/therapy MH - Obesity MH - Quality of Life MH - Treatment Outcome MH - Weight Loss/physiology OTO - NOTNLM OT - Binge-eating disorder OT - diagnosis OT - emerging treatments OT - pathophysiological mechanisms OT - pharmacotherapy OT - psychotherapy EDAT- 2023/11/02 06:42 MHDA- 2023/12/17 09:45 CRDT- 2023/11/02 05:32 PHST- 2023/12/17 09:45 [medline] PHST- 2023/11/02 06:42 [pubmed] PHST- 2023/11/02 05:32 [entrez] AID - 10.1080/14737175.2023.2273392 [doi] PST - ppublish SO - Expert Rev Neurother. 2023 Jul-Dec;23(12):1097-1111. doi: 10.1080/14737175.2023.2273392. Epub 2023 Dec 15.