PMID- 37916848
OWN - NLM
STAT- MEDLINE
DCOM- 20240411
LR  - 20240411
IS  - 1531-4995 (Electronic)
IS  - 0023-852X (Linking)
VI  - 134
IP  - 5
DP  - 2024 May
TI  - Two-Year Outcomes After Radiofrequency Neurolysis of Posterior Nasal Nerve in 
      Chronic Rhinitis.
PG  - 2077-2084
LID - 10.1002/lary.31120 [doi]
AB  - OBJECTIVE: To assess the long-term safety and effectiveness of 
      temperature-controlled radiofrequency (TCRF) neurolysis of the posterior nasal 
      nerve (PNN), a minimally invasive treatment for chronic rhinitis. METHODS: A 
      prospective, single-arm study of 129 patients at 16 centers (United States, 
      Germany) was conducted. Patient-reported outcome measures were the 24-h 
      reflective total nasal symptom score (rTNSS) and mini rhinoconjunctivitis quality 
      of life questionnaire (MiniRQLQ). Postnasal drip and cough symptoms were assessed 
      using a 4-point scale. RESULTS: The mean pretreatment rTNSS was 7.8 (95% CI, 
      7.5-8.1). The significant rTNSS treatment effect at 3 months (-4.2 [95% CI, -4.6 
      to -3.8]; p < 0.001) was sustained through 2 years (-4.5 [95% CI, -5.0 to -3.9]; 
      p < 0.001), a 57.7% improvement. At 2 years, the proportion of patients with a 
      minimal clinically important difference (MCID) of >/=30% improvement in rTNSS from 
      baseline was 80.0% (95% CI, 71.4%-86.5%). Individual postnasal drip and cough 
      symptom scores were significantly improved from baseline through 2 years. The 
      proportion of patients who reached the MCID for the MiniRQLQ (>/=0.4-point 
      improvement) at 2 years was 77.4% (95% CI, 68.5%-84.3%). Of 81 patients using 
      chronic rhinitis medications at baseline, 61.7% either stopped all medication use 
      (28.4%) or stopped or decreased (33.3%) use of >/=1 medication class at 2 years. No 
      device/procedure-related serious adverse events were reported throughout 2 years. 
      CONCLUSION: TCRF neurolysis of the PNN resulted in sustained improvements in 
      chronic rhinitis symptom burden and quality of life through 2 years, accompanied 
      by a substantial decrease in medication burden. LEVEL OF EVIDENCE: 4 
      Laryngoscope, 134:2077-2084, 2024.
CI  - (c) 2023 The Authors. The Laryngoscope published by Wiley Periodicals LLC on behalf 
      of The American Laryngological, Rhinological and Otological Society, Inc.
FAU - Lee, Jivianne T
AU  - Lee JT
AUID- ORCID: 0000-0002-0711-855X
AD  - Department of Head and Neck Surgery, UCLA David Geffen School of Medicine, Los 
      Angeles, California, U.S.A.
FAU - Abbas, Gregory M
AU  - Abbas GM
AD  - Advanced ENT and Allergy, Louisville, Kentucky, U.S.A.
FAU - Charous, Daniel D
AU  - Charous DD
AD  - Arizona Desert Ear, Nose & Throat Specialists, Goodyear, Arizona, U.S.A.
FAU - Cuevas, Mandy
AU  - Cuevas M
AD  - Department of Otorhinolaryngology Head and Neck Surgery, Faculty of Medicine and 
      University Hospital Carl Gustav Carus, Technische Universitat Dresden, Dresden, 
      Germany.
FAU - Goktas, Onder
AU  - Goktas O
AD  - ENT-Center, HNO-Zentrum am Kudamm, Berlin, Germany.
FAU - Loftus, Patricia A
AU  - Loftus PA
AUID- ORCID: 0000-0002-5785-183X
AD  - Department of Otolaryngology-Head and Neck Surgery, University of California, San 
      Francisco, California, U.S.A.
FAU - Nachlas, Nathan E
AU  - Nachlas NE
AD  - ENT and Allergy Associates of Florida, Boca Raton, Florida, U.S.A.
FAU - Toskala, Elina M
AU  - Toskala EM
AD  - Department of Otolaryngology - Head and Neck Surgery, Thomas Jefferson 
      University, Philadelphia, Pennsylvania, U.S.A.
FAU - Watkins, Jeremy P
AU  - Watkins JP
AD  - Fort Worth ENT Group, Fort Worth, Texas, U.S.A.
FAU - Brehmer, Detlef
AU  - Brehmer D
AUID- ORCID: 0000-0001-5148-9342
AD  - Faculty of Medicine, University Witten/Herdecke, Witten, Germany.
AD  - Department of Electrical Engineering and Applied Natural Sciences, Westphalian 
      University of Applied Sciences, Gelsenkirchen, Germany.
AD  - Department of Otorhinolaryngology, Private ENT Practice, Gottingen, Germany.
LA  - eng
GR  - Aerin Medical/
PT  - Journal Article
DEP - 20231102
PL  - United States
TA  - Laryngoscope
JT  - The Laryngoscope
JID - 8607378
SB  - IM
MH  - Humans
MH  - *Quality of Life
MH  - Prospective Studies
MH  - *Rhinitis/surgery/drug therapy
MH  - Nose
MH  - Cough
MH  - Treatment Outcome
OTO - NOTNLM
OT  - MiniRQLQ
OT  - chronic rhinitis
OT  - neurolysis
OT  - posterior nasal nerve
OT  - quality of life
OT  - rTNSS
OT  - radiofrequency
OT  - temperature-controlled
EDAT- 2023/11/02 12:45
MHDA- 2024/04/11 06:42
CRDT- 2023/11/02 09:13
PHST- 2023/09/22 00:00 [revised]
PHST- 2023/08/23 00:00 [received]
PHST- 2023/10/04 00:00 [accepted]
PHST- 2024/04/11 06:42 [medline]
PHST- 2023/11/02 12:45 [pubmed]
PHST- 2023/11/02 09:13 [entrez]
AID - 10.1002/lary.31120 [doi]
PST - ppublish
SO  - Laryngoscope. 2024 May;134(5):2077-2084. doi: 10.1002/lary.31120. Epub 2023 Nov 
      2.