PMID- 37917279
OWN - NLM
STAT- Publisher
LR  - 20231102
IS  - 1573-4919 (Electronic)
IS  - 0300-8177 (Linking)
DP  - 2023 Nov 2
TI  - NRF2 signaling pathway and telomere length in aging and age-related diseases.
LID - 10.1007/s11010-023-04878-x [doi]
AB  - The transcription factor nuclear factor erythroid 2-related factor 2 (NRF2) is 
      well recognized as a critical regulator of redox, metabolic, and protein 
      homeostasis, as well as the regulation of inflammation. An age-associated decline 
      in NRF2 activity may allow oxidative stress to remain unmitigated and affect key 
      features associated with the aging phenotype, including telomere shortening. 
      Telomeres, the protective caps of eukaryotic chromosomes, are highly susceptible 
      to oxidative DNA damage, which can accelerate telomere shortening and, 
      consequently, lead to premature senescence and genomic instability. In this 
      review, we explore how the dysregulation of NRF2, coupled with an increase in 
      oxidative stress, might be a major determinant of telomere shortening and 
      age-related diseases. We discuss the relevance of the connection between NRF2 
      deficiency in aging and telomere attrition, emphasizing the importance of 
      studying this functional link to enhance our understanding of aging pathologies. 
      Finally, we present a number of compounds that possess the ability to restore 
      NRF2 function, maintain a proper redox balance, and preserve telomere length 
      during aging.
CI  - (c) 2023. The Author(s).
FAU - Medoro, Alessandro
AU  - Medoro A
AD  - Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 
      Via F. De Sanctis, s.n.c., 86100, Campobasso, Italy.
FAU - Saso, Luciano
AU  - Saso L
AD  - Department of Physiology and Pharmacology "Vittorio Erspamer", Sapienza 
      University of Rome, Rome, Italy.
FAU - Scapagnini, Giovanni
AU  - Scapagnini G
AD  - Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 
      Via F. De Sanctis, s.n.c., 86100, Campobasso, Italy.
FAU - Davinelli, Sergio
AU  - Davinelli S
AD  - Department of Medicine and Health Sciences "V. Tiberio", University of Molise, 
      Via F. De Sanctis, s.n.c., 86100, Campobasso, Italy. sergio.davinelli@unimol.it.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231102
PL  - Netherlands
TA  - Mol Cell Biochem
JT  - Molecular and cellular biochemistry
JID - 0364456
SB  - IM
OTO - NOTNLM
OT  - Aging
OT  - NRF2
OT  - Oxidative stress
OT  - Telomere length
EDAT- 2023/11/02 18:43
MHDA- 2023/11/02 18:43
CRDT- 2023/11/02 12:08
PHST- 2023/08/19 00:00 [received]
PHST- 2023/10/07 00:00 [accepted]
PHST- 2023/11/02 18:43 [medline]
PHST- 2023/11/02 18:43 [pubmed]
PHST- 2023/11/02 12:08 [entrez]
AID - 10.1007/s11010-023-04878-x [pii]
AID - 10.1007/s11010-023-04878-x [doi]
PST - aheadofprint
SO  - Mol Cell Biochem. 2023 Nov 2. doi: 10.1007/s11010-023-04878-x.