PMID- 37918541
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20240202
IS  - 1879-1298 (Electronic)
IS  - 0045-6535 (Linking)
VI  - 346
DP  - 2024 Jan
TI  - PCB126 impairs human sperm functions by affecting post-translational 
      modifications and mitochondrial functions.
PG  - 140532
LID - S0045-6535(23)02802-3 [pii]
LID - 10.1016/j.chemosphere.2023.140532 [doi]
AB  - Over the past few decades, there has been a consistent decline in semen quality 
      across the globe, with environmental pollution being identified as the primary 
      cause. Among the various contaminants present in the environment, persistent 
      organic pollutants (POPs) have garnered significant attention due to their high 
      toxicity, slow degradation, bio-accumulation, and long-range migration. PCBs, 
      which include 210 congeners, are a crucial type of POPs that are known to have 
      harmful effects on the environment and human health. Among the various PCB 
      congeners, 3,3',4,4',5-pentachlorobiphenyl (PCB126) is a typical environmental 
      endocrine-disrupting chemical that is widely distributed and has been associated 
      with several health hazards. However, the impact and mechanism of PCB126 on human 
      sperm function has not been fully elucidated. We aimed to investigate the effects 
      of different concentrations of PCB126 (0.01, 0.1, 1, 10 mug/mL) on sperm motility, 
      viability, hyperactivation, and acrosome reaction after incubation for different 
      periods (1 and 2 h), delving deeper into the molecular mechanism of human sperm 
      dysfunction caused by PCB126. First, we investigated the link between PCB126 
      treatment and the occurrence of protein modifications that are critical to sperm 
      function regulation, such as tyrosine phosphorylation and lysine glutarylation. 
      Second, we examined the potential impact of PCB126 on different parameters 
      related to mitochondrial function, including reactive oxygen species, 
      malondialdehyde levels, mitochondrial membrane potential, mitochondria 
      respiration and adenosine triphosphate generation. Our findings indicate that 
      exposure to environmental pollutants such as PCB126 in vitro may have a negative 
      impact on human sperm functions by interfering with post-translational 
      modifications and mitochondrial functions.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Yang, Yebin
AU  - Yang Y
AD  - College of Chemistry and Biological Engineering, Yichun University, Yichun, 
      China.
FAU - Mei, Guangquan
AU  - Mei G
AD  - Jiangxi Provincial Key Laboratory of Natural Active Pharmaceutical Constituents, 
      Department of Chemistry and Bioengineering, Yichun University, Yichun, China; Key 
      Laboratory of Jiangxi University for Applied Chemistry and Chemical Biology, 
      Yichun University, Yichun, China.
FAU - Yang, Liu
AU  - Yang L
AD  - College of Chemistry and Biological Engineering, Yichun University, Yichun, 
      China.
FAU - Luo, Tao
AU  - Luo T
AD  - Institute of Life Science and School of Life Science, Nanchang University, 
      Nanchang, China.
FAU - Wu, Runwen
AU  - Wu R
AD  - Center for Translational Medicine, Department of Medicine, Yichun University, 
      Yichun, China.
FAU - Peng, Shenglin
AU  - Peng S
AD  - Yichun People's Hospital, Jiangxi Province, Yichun, China.
FAU - Peng, Zhen
AU  - Peng Z
AD  - Yichun People's Hospital, Jiangxi Province, Yichun, China.
FAU - Cui, Jiajun
AU  - Cui J
AD  - Center for Translational Medicine, Department of Medicine, Yichun University, 
      Yichun, China.
FAU - Cheng, Yimin
AU  - Cheng Y
AD  - Jiangxi Provincial Key Laboratory of Natural Active Pharmaceutical Constituents, 
      Department of Chemistry and Bioengineering, Yichun University, Yichun, China; 
      Center for Translational Medicine, Department of Medicine, Yichun University, 
      Yichun, China. Electronic address: 1169331029@qq.com.
LA  - eng
PT  - Journal Article
DEP - 20231031
PL  - England
TA  - Chemosphere
JT  - Chemosphere
JID - 0320657
RN  - TSH69IA9XF (3,4,5,3',4'-pentachlorobiphenyl)
RN  - DFC2HB4I0K (Polychlorinated Biphenyls)
RN  - 0 (Environmental Pollutants)
SB  - IM
MH  - Humans
MH  - Male
MH  - *Polychlorinated Biphenyls/toxicity
MH  - Semen Analysis
MH  - Sperm Motility
MH  - Semen
MH  - *Environmental Pollutants/toxicity
MH  - Spermatozoa
MH  - Protein Processing, Post-Translational
MH  - Mitochondria
OTO - NOTNLM
OT  - 3,3',4,4',5-pentachlorobiphenyl
OT  - Mitochondrial dysfunction
OT  - Post-translational modification
OT  - Reactive oxygen species
OT  - human sperm
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/03 00:42
MHDA- 2023/11/27 12:44
CRDT- 2023/11/02 20:15
PHST- 2023/04/22 00:00 [received]
PHST- 2023/10/17 00:00 [revised]
PHST- 2023/10/23 00:00 [accepted]
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/11/03 00:42 [pubmed]
PHST- 2023/11/02 20:15 [entrez]
AID - S0045-6535(23)02802-3 [pii]
AID - 10.1016/j.chemosphere.2023.140532 [doi]
PST - ppublish
SO  - Chemosphere. 2024 Jan;346:140532. doi: 10.1016/j.chemosphere.2023.140532. Epub 
      2023 Oct 31.