PMID- 37918559
OWN - NLM
STAT- MEDLINE
DCOM- 20240214
LR  - 20240214
IS  - 1873-1597 (Electronic)
IS  - 1572-1000 (Linking)
VI  - 44
DP  - 2023 Dec
TI  - Photodynamic antimicrobial chemotherapy activities of phthalocyanine-antibiotic 
      conjugates against bacterial biofilms and interactions with extracellular 
      polymeric substances.
PG  - 103878
LID - S1572-1000(23)00605-1 [pii]
LID - 10.1016/j.pdpdt.2023.103878 [doi]
AB  - This study sheds light on how to rationally design efficient photodynamic 
      antimicrobial chemotherapy (PACT) agents by covalently linking phthalocyanines 
      (Pcs) as photosensitizers with an antibiotic: Ciprofloxacin (CIP). Pcs used are 
      zinc (II) 3-(4-((3,17,23-tris(4-(Benzo(d)thiazol-2-yl] thiol) 
      phthalocyanine-9-yl) oxy) phenyl) propanoic acid (1) and zinc (II) 
      3-(4-(3,17,23-tris(3-(4-(triphenylphosphine) butyl) benzo[d]thiazol-3-ium bromide 
      phthalocyanine-9-yl) oxy) phenyl) propanoic acid (2). High singlet oxygen quantum 
      yields are observed in the presence of CIP. Square wave voltammetry was used to 
      analyse the Pc-CIP uptake by bacteria biofilms of Streptococcus pneumoniae (S. 
      pneumonia) and Escherichia coli (E. coli). Electrochemical impedance spectroscopy 
      and scanning electron spectroscopy were used to study the stability of the 
      biofilms in the presence Pc-CIP complexes and when exposed to light. Raman and 
      time of flight-secondary ion mass spectrometry (TOF-SIMS) are used to identify 
      the breakdown of cellular components of the biofilm and penetration of the Pc-CIP 
      into the biofilms, respectively.
CI  - Copyright (c) 2023. Published by Elsevier B.V.
FAU - Magadla, Aviwe
AU  - Magadla A
AD  - Institute for Nanotechnology Innovation, Rhodes University, Makhanda 6140, South 
      Africa.
FAU - Mpeta, Lekhetho S
AU  - Mpeta LS
AD  - Institute for Nanotechnology Innovation, Rhodes University, Makhanda 6140, South 
      Africa.
FAU - Britton, Jonathan
AU  - Britton J
AD  - Institute for Nanotechnology Innovation, Rhodes University, Makhanda 6140, South 
      Africa.
FAU - Nyokong, Tebello
AU  - Nyokong T
AD  - Institute for Nanotechnology Innovation, Rhodes University, Makhanda 6140, South 
      Africa. Electronic address: t.nyokong@ru.ac.za.
LA  - eng
PT  - Journal Article
DEP - 20231101
PL  - Netherlands
TA  - Photodiagnosis Photodyn Ther
JT  - Photodiagnosis and photodynamic therapy
JID - 101226123
RN  - 0 (Anti-Bacterial Agents)
RN  - 0 (Photosensitizing Agents)
RN  - V5PUF4VLGY (phthalocyanine)
RN  - 0 (Propionates)
RN  - 0 (Indoles)
RN  - 0 (Antineoplastic Agents)
RN  - J41CSQ7QDS (Zinc)
RN  - 0 (Isoindoles)
SB  - IM
MH  - Anti-Bacterial Agents/pharmacology/chemistry
MH  - Photosensitizing Agents/pharmacology/chemistry
MH  - Extracellular Polymeric Substance Matrix
MH  - Propionates
MH  - *Photochemotherapy/methods
MH  - Escherichia coli
MH  - Indoles/pharmacology/chemistry
MH  - Biofilms
MH  - *Antineoplastic Agents/pharmacology
MH  - Zinc
MH  - *Isoindoles
OTO - NOTNLM
OT  - Biofilms
OT  - Ciprofloxacin
OT  - Electrochemical impedance spectroscopy
OT  - Photodynamic Therapy
OT  - Phthalocyanines
OT  - Raman spectroscopy
OT  - Square wave voltammetry
EDAT- 2023/11/03 00:42
MHDA- 2024/02/12 18:42
CRDT- 2023/11/02 20:15
PHST- 2023/08/01 00:00 [received]
PHST- 2023/10/18 00:00 [revised]
PHST- 2023/10/31 00:00 [accepted]
PHST- 2024/02/12 18:42 [medline]
PHST- 2023/11/03 00:42 [pubmed]
PHST- 2023/11/02 20:15 [entrez]
AID - S1572-1000(23)00605-1 [pii]
AID - 10.1016/j.pdpdt.2023.103878 [doi]
PST - ppublish
SO  - Photodiagnosis Photodyn Ther. 2023 Dec;44:103878. doi: 
      10.1016/j.pdpdt.2023.103878. Epub 2023 Nov 1.