PMID- 3791885
OWN - NLM
STAT- MEDLINE
DCOM- 19870212
LR  - 20190919
IS  - 0141-9854 (Print)
IS  - 0141-9854 (Linking)
VI  - 8
IP  - 4
DP  - 1986
TI  - Combination therapy of steroids and immunoglobulin in chronic refractory 
      idiopathic thrombocytopenic purpura (ITP) enabling renal stone fragmentation by 
      lithotripsy.
PG  - 315-9
AB  - A 27-year-old woman with idiopathic thrombocytopenic purpura (ITP), which had 
      relapsed following splenectomy, was found to be refractory to a wide range of 
      individual immunosuppressive agents. However, a normal platelet count was 
      achieved with high-dose dexamethasone followed by intravenous immunoglobulins 
      (i.v. Ig). Either agent used alone had previously produced clinically inadequate 
      platelet increments. With this regime, successful renal stone fragmentation by 
      lithotripsy was undertaken, which required no blood product support over the 
      peri-operative period. It is suggested that patients with refractory ITP 
      requiring major procedures, who have not responded to i.v. Ig treatment, merit a 
      repeat trial following high-dose steroid.
FAU - Duncombe, A S
AU  - Duncombe AS
FAU - Kesteven, P J
AU  - Kesteven PJ
FAU - Savidge, G F
AU  - Savidge GF
LA  - eng
PT  - Case Reports
PT  - Journal Article
PL  - England
TA  - Clin Lab Haematol
JT  - Clinical and laboratory haematology
JID - 7907061
RN  - 0 (Immunoglobulins)
RN  - 7S5I7G3JQL (Dexamethasone)
SB  - IM
MH  - Adult
MH  - Dexamethasone/*therapeutic use
MH  - Drug Therapy, Combination
MH  - Female
MH  - Humans
MH  - Immunization, Passive
MH  - Immunoglobulins/*administration & dosage
MH  - Injections, Intravenous
MH  - Kidney Calculi/complications/therapy
MH  - *Lithotripsy
MH  - Platelet Count/drug effects
MH  - Purpura, Thrombocytopenic/complications/*drug therapy
EDAT- 1986/01/01 00:00
MHDA- 1986/01/01 00:01
CRDT- 1986/01/01 00:00
PHST- 1986/01/01 00:00 [pubmed]
PHST- 1986/01/01 00:01 [medline]
PHST- 1986/01/01 00:00 [entrez]
AID - 10.1111/j.1365-2257.1986.tb00118.x [doi]
PST - ppublish
SO  - Clin Lab Haematol. 1986;8(4):315-9. doi: 10.1111/j.1365-2257.1986.tb00118.x.