PMID- 37919847
OWN - NLM
STAT- MEDLINE
DCOM- 20231106
LR  - 20231110
IS  - 1539-6304 (Electronic)
IS  - 1088-5412 (Linking)
VI  - 44
IP  - 6
DP  - 2023 Nov 1
TI  - Cold-induced urticaria in children: A multicenter, retrospective cohort study.
PG  - e36-e43
LID - 10.2500/aap.2023.44.230050 [doi]
AB  - Background: Studies of cold-induced urticaria (ColdU) in pediatric patients are 
      limited and not well characterized. Objective: The objective of the study was to 
      investigate the characteristics of ColdU in children. Methods: A multicenter, 
      retrospective chart review was performed in children ages </=18 years diagnosed 
      with ColdU at 11 pediatric allergy and immunology centers in Turkey between 
      September 1, 2010, and August 31, 2022. Results: A total of 83 children with 
      ColdU were included, 54.2% were girls, and the mean age of symptom onset was 8.8 
      years. The median duration of ColdU at the time of diagnosis was significantly 
      higher in the girls than in the boys (1.0 years [0.0-13.8 years] versus 0.3 years 
      [0.0-15.0 years]; p = 0.007). All the patients underwent an ice cube test, and 
      71.1% were found positive (typical ColdU). The mean +/- standard deviation age of 
      onset was significantly higher in the patients with typical ColdU versus atypical 
      patients (9.4 +/- 4.5 years versus 7.3 +/- 4.5 years; p = 0.041). Swimming alone and 
      in combination with the wind were significantly the most reported triggers in 
      patients with cold-induced anaphylaxis (ColdA) when compared with patients with 
      ColdU and with nonanaphylactic symptoms (70.0% versus 28.9% [p = 0.022], and 
      50.0% versus 4.1% [p < 0.001], respectively). Only patients with other chronic 
      urticaria were found to be associated with the development of typical ColdU (p = 
      0.036). The median total serum immunoglobulin E (IgE) was significantly higher in 
      typical ColdU than in atypical patients (72.5 IU/mL [3.86 - 2500 IU/mL] versus 
      30.0 IU/mL [0.83 - 1215 IU/mL]; p = 0.007); however, total serum IgE differences 
      were not found to affect ColdU resolution between the two groups (p = 0.204). The 
      resolution was documented in 30.4%. Conclusion: Those who were boys and had a 
      positive ice cube test result could have an association with earlier onset of 
      ColdU. Those swimming alone on a windy day were at highest risk for ColdA. It is 
      still unclear what characteristics are associated with the resolution of ColdU, 
      and this warrants further investigation.
FAU - Karabag Citlak, Hilal
AU  - Karabag Citlak H
AD  - From the Department of Pediatric Immunology and Allergy, Karadeniz Technical 
      University Faculty of Medicine, Trabzon, Turkey.
FAU - Azkur, Dilek
AU  - Azkur D
AD  - Department of Pediatric Immunology and Allergy, Kirikkale University Faculty of 
      Medicine, Kirikkale, Turkey.
FAU - Kavas Yildiz, Yuksel
AU  - Kavas Yildiz Y
AD  - Department of Pediatric Immunology and Allergy, Ankara Training and Research 
      Hospital, Ankara, Turkey.
FAU - Demirel, Ali Can
AU  - Demirel AC
AD  - Department of Pediatric Immunology and Allergy, Bilkent City Hospital, University 
      of Health Sciences, Ankara, Turkey.
FAU - Kot, Hakan
AU  - Kot H
AD  - From the Department of Pediatric Immunology and Allergy, Karadeniz Technical 
      University Faculty of Medicine, Trabzon, Turkey.
FAU - Vezir, Emine
AU  - Vezir E
AD  - Department of Pediatric Immunology and Allergy, Ankara Training and Research 
      Hospital, Ankara, Turkey.
FAU - Kilic, Mehmet
AU  - Kilic M
AD  - Department of Pediatric Immunology and Allergy, Firat University Faculty of 
      Medicine, Elazig, Turkey.
FAU - Usta Guc, Belgin
AU  - Usta Guc B
AD  - Department of Pediatric Immunology and Allergy, Adana City Hospital, Adana, 
      Turkey.
FAU - Kilic, Mehtap
AU  - Kilic M
AD  - Pediatric Immunology and Allergy practitioner, Samsun, Turkey.
FAU - Yakici, Nalan
AU  - Yakici N
AD  - Department of Pediatric Immunology and Allergy, Recep Tayyip Erdogan University 
      Faculty of Medicine, Rize, Turkey, and.
FAU - Kocabas, Can Naci
AU  - Kocabas CN
AD  - Department of Pediatric Immunology and Allergy, Sitki Kocman University Faculty 
      of Medicine, Mugla, Turkey.
FAU - Dibek Misirlioglu, Emine
AU  - Dibek Misirlioglu E
AD  - Department of Pediatric Immunology and Allergy, Bilkent City Hospital, University 
      of Health Sciences, Ankara, Turkey.
FAU - Civelek, Ersoy
AU  - Civelek E
AD  - Department of Pediatric Immunology and Allergy, Bilkent City Hospital, University 
      of Health Sciences, Ankara, Turkey.
FAU - Orhan, Fazil
AU  - Orhan F
AD  - From the Department of Pediatric Immunology and Allergy, Karadeniz Technical 
      University Faculty of Medicine, Trabzon, Turkey.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PL  - United States
TA  - Allergy Asthma Proc
JT  - Allergy and asthma proceedings
JID - 9603640
RN  - 0 (Ice)
RN  - 37341-29-0 (Immunoglobulin E)
SB  - IM
MH  - Male
MH  - Female
MH  - Child
MH  - Humans
MH  - Child, Preschool
MH  - Adolescent
MH  - Retrospective Studies
MH  - Ice
MH  - *Urticaria/diagnosis/epidemiology/etiology
MH  - *Chronic Urticaria
MH  - Immunoglobulin E
EDAT- 2023/11/03 06:43
MHDA- 2023/11/06 06:42
CRDT- 2023/11/03 00:59
PHST- 2023/11/06 06:42 [medline]
PHST- 2023/11/03 06:43 [pubmed]
PHST- 2023/11/03 00:59 [entrez]
AID - 10.2500/aap.2023.44.230050 [doi]
PST - ppublish
SO  - Allergy Asthma Proc. 2023 Nov 1;44(6):e36-e43. doi: 10.2500/aap.2023.44.230050.