PMID- 37921037
OWN - NLM
STAT- MEDLINE
DCOM- 20240118
LR  - 20240118
IS  - 1439-0264 (Electronic)
IS  - 0340-2096 (Linking)
VI  - 53
IP  - 1
DP  - 2024 Jan
TI  - An investigation of the distributions of ferroptosis and necroptosis mediators in 
      the maternal-fetal interface at different days of rat pregnancy.
PG  - e12991
LID - 10.1111/ahe.12991 [doi]
AB  - Ferroptosis and necroptosis are recognized as playing major roles in the 
      regulation of various physiological processes. However, the physiological role of 
      the cell death mediated by these two pathways in the developmental process has 
      not yet been clearly established. This study investigated ferroptosis and 
      necroptosis signalling pathways in maternal-fetal tissue in the different 
      gestational days (GD) of rat pregnancy using immunohistochemical and western blot 
      methods in order to fill this gap. Twenty-four female Wistar albino rats were 
      mated and divided into three groups. Maternal-fetal tissue samples were collected 
      on GD 5, 12 and 19 of pregnancy. Expression and total protein levels of the 
      markers glutathione peroxidase-4, soluble transporter family 7 member 11, 
      transferrin receptor, receptor-interacting serine/threonine-protein kinase 1, 
      receptor-interacting serine/threonine-protein kinase 3 and mixed lineage kinase 
      domain-like protein were investigated on both the maternal and fetal surfaces of 
      the placenta using immunohistochemical and western blot methods. The results 
      showed varying levels of protein expression of both ferroptosis and necroptosis 
      mediators in the GD 5, 12 and 19 of pregnancy. Immunohistochemical analyses 
      revealed that these mediators were located on both the maternal (decidua and 
      metrial gland) and fetal surfaces (labyrinth zone, yolk sac and basal zone) and 
      that their expression levels changed in the different GD. The findings revealed 
      the existence of important ferroptosis and necroptosis pathway mediators in rat 
      maternal-fetal tissue. These results may provide a molecular framework for a 
      better understanding of the communication between the placenta, decidua and fetus 
      during the developmental process.
CI  - (c) 2023 Wiley-VCH GmbH. Published by John Wiley & Sons Ltd.
FAU - Tatar, Musa
AU  - Tatar M
AUID- ORCID: 0000-0002-5707-8832
AD  - Department of Histology and Embryology, Faculty of Veterinary Medicine, Kastamonu 
      University, Kastamonu, Turkey.
FAU - Tufekci, Kiymet Kubra
AU  - Tufekci KK
AUID- ORCID: 0000-0002-4722-3813
AD  - Department of Histology and Embryology, Faculty of Medicine, Kastamonu 
      University, Kastamonu, Turkey.
LA  - eng
PT  - Journal Article
DEP - 20231103
PL  - Germany
TA  - Anat Histol Embryol
JT  - Anatomia, histologia, embryologia
JID - 7704218
RN  - EC 2.7.- (Protein Kinases)
RN  - 2ZD004190S (Threonine)
RN  - 452VLY9402 (Serine)
SB  - IM
MH  - Pregnancy
MH  - Rats
MH  - Female
MH  - Animals
MH  - *Ferroptosis
MH  - Necroptosis
MH  - Rats, Wistar
MH  - Protein Kinases
MH  - Threonine
MH  - Serine
OTO - NOTNLM
OT  - cell death
OT  - decidua
OT  - ferroptosis
OT  - maternal-fetal interface
OT  - necroptosis
EDAT- 2023/11/03 06:44
MHDA- 2024/01/18 06:42
CRDT- 2023/11/03 05:28
PHST- 2023/09/28 00:00 [revised]
PHST- 2023/07/16 00:00 [received]
PHST- 2023/10/17 00:00 [accepted]
PHST- 2024/01/18 06:42 [medline]
PHST- 2023/11/03 06:44 [pubmed]
PHST- 2023/11/03 05:28 [entrez]
AID - 10.1111/ahe.12991 [doi]
PST - ppublish
SO  - Anat Histol Embryol. 2024 Jan;53(1):e12991. doi: 10.1111/ahe.12991. Epub 2023 Nov 
      3.