PMID- 3792453
OWN - NLM
STAT- MEDLINE
DCOM- 19870211
LR  - 20190624
IS  - 0014-2999 (Print)
IS  - 0014-2999 (Linking)
VI  - 130
IP  - 3
DP  - 1986 Nov 4
TI  - Antiopioid activity of the cardioexcitatory peptide in central modulation of 
      cardiovascular functions.
PG  - 315-8
AB  - Intracerebroventricular (i.c.v.) injection of [D-Ala2,Leu5]enkephalin produced 
      depressor and bradycardiac responses which were prevented by naloxone or FMRF-NH2 
      pretreatment. Intrathecal injection of FMRF-NH2 to rats in hemorrhagic shock 
      resulted in a slight but significant increase in blood pressure, and prevented 
      the further decrease in heart rate which was observed in the control group. It is 
      concluded that FMRF-NH2 may act as an antiopioid substance in central modulation 
      of cardiovascular functions.
FAU - Chai, S H
AU  - Chai SH
FAU - Tang, J
AU  - Tang J
FAU - Han, J S
AU  - Han JS
LA  - eng
PT  - Journal Article
PL  - Netherlands
TA  - Eur J Pharmacol
JT  - European journal of pharmacology
JID - 1254354
RN  - 0 (Endorphins)
RN  - 0 (Nerve Tissue Proteins)
RN  - 36B82AMQ7N (Naloxone)
RN  - 58822-25-6 (Enkephalin, Leucine)
RN  - 63631-40-3 (Enkephalin, Leucine-2-Alanine)
RN  - 64190-70-1 (FMRFamide)
RN  - 65189-64-2 (enkephalinamide-Leu, Ala(2)-)
SB  - IM
MH  - Animals
MH  - Blood Pressure/drug effects
MH  - Cardiovascular System/*drug effects
MH  - Endorphins/*antagonists & inhibitors
MH  - Enkephalin, Leucine/analogs & derivatives/antagonists & inhibitors
MH  - *Enkephalin, Leucine-2-Alanine/*analogs & derivatives
MH  - FMRFamide
MH  - Female
MH  - Heart Rate/drug effects
MH  - Injections, Intraventricular
MH  - Male
MH  - Naloxone/pharmacology
MH  - Nerve Tissue Proteins/*pharmacology
MH  - Rats
MH  - Shock, Hemorrhagic/physiopathology
EDAT- 1986/11/04 00:00
MHDA- 1986/11/04 00:01
CRDT- 1986/11/04 00:00
PHST- 1986/11/04 00:00 [pubmed]
PHST- 1986/11/04 00:01 [medline]
PHST- 1986/11/04 00:00 [entrez]
AID - 0014-2999(86)90284-0 [pii]
AID - 10.1016/0014-2999(86)90284-0 [doi]
PST - ppublish
SO  - Eur J Pharmacol. 1986 Nov 4;130(3):315-8. doi: 10.1016/0014-2999(86)90284-0.