PMID- 37926084 OWN - NLM STAT- MEDLINE DCOM- 20231225 LR - 20231225 IS - 1423-0259 (Electronic) IS - 0030-3747 (Linking) VI - 66 IP - 1 DP - 2023 TI - Discovery of Clinical Manifestations in Spontaneous Glaucoma Suspect Nonhuman Primates. PG - 1406-1416 LID - 10.1159/000533865 [doi] AB - INTRODUCTION: The primary aim of this study was to assess the longitudinal changes in retinal nerve fiber layer (RNFL) thickness and relative ONH parameters using spectral-domain optical coherence tomography (SD-OCT) in the living eyes of nonhuman primates with spontaneous glaucoma. METHODS: Totally 9 macaque subjects underwent a standard fundus photo and OCT examination, including 3 adult monkeys with stable elevated intraocular pressure (IOP) as the glaucoma suspect group and 6 normal IOP monkeys as the control group. Each eye of primates with IOP measurement was repeated three times. OCT measurements recorded RNFL, Bruch's membrane opening (BMO) minimum rim width (MRW). The follow-up scan of glaucomatous subjects was undergone in 10 months. RESULTS: The mean ages of glaucoma and healthy subjects are 19.33 +/- 0.33 and 20.5 +/- 1.46 years. Elevated IOP was achieved in three nonhuman primate eyes with an average increase of 10 mm Hg over the study period. Elevated IOP was associated with decreased RNFL thickness in all the regions and decreased RNFL phase retardation in the superior and inferior regions. When averaged over the entire retinal area, only the whole RNFL and temporal regions showed a significant decrease. The mean IPL thicknesses are 87.17 +/- 2.15 mum in glaucomatous and 93.33 +/- 1.51 mum in healthy eyes (p = 0.03). Lamina cribrosa parameters are measured from the OCT images and showed significant differences between glaucoma primates and normal primates. CONCLUSIONS: Of the measured parameters, decreased RNFL and MRW were correlated with glaucomatous damage. Natural glaucoma primate can be a natural glaucoma model which is closer to glaucoma in humans. CI - (c) 2023 The Author(s). Published by S. Karger AG, Basel. FAU - Jia, Xu AU - Jia X AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. AD - Affiliated Hospital of Guizhou Medical University, Guiyang, China. FAU - Yu, Ziyu AU - Yu Z AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. FAU - Wu, Jian AU - Wu J AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. AD - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Hou, Simeng AU - Hou S AD - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Du, Yifan AU - Du Y AD - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Zhu, Yingting AU - Zhu Y AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. FAU - Li, Zhidong AU - Li Z AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. FAU - Tu, Shu AU - Tu S AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. FAU - Zhao, Ling AU - Zhao L AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. FAU - Su, Wenru AU - Su W AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. FAU - Wang, Ningli AU - Wang N AD - Beijing Institute of Ophthalmology, Beijing Tongren Eye Center, Beijing Ophthalmology & Visual Sciences Key Laboratory, Beijing Tongren Hospital, Capital Medical University, Beijing, China. FAU - Zhuo, Yehong AU - Zhuo Y AD - State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China. LA - eng PT - Journal Article DEP - 20231104 PL - Switzerland TA - Ophthalmic Res JT - Ophthalmic research JID - 0267442 SB - IM MH - Adult MH - Animals MH - Humans MH - Adolescent MH - Young Adult MH - *Optic Disk MH - Intraocular Pressure MH - Retinal Ganglion Cells MH - *Glaucoma/diagnosis MH - *Ocular Hypertension/diagnosis MH - Tomography, Optical Coherence/methods MH - Primates OTO - NOTNLM OT - Glaucoma OT - Nonhuman primates OT - Rhesus macaque OT - Spectrum domain optical coherence tomography EDAT- 2023/11/06 00:41 MHDA- 2023/12/25 06:43 CRDT- 2023/11/05 18:25 PHST- 2022/05/24 00:00 [received] PHST- 2023/08/04 00:00 [accepted] PHST- 2023/12/25 06:43 [medline] PHST- 2023/11/06 00:41 [pubmed] PHST- 2023/11/05 18:25 [entrez] AID - 000533865 [pii] AID - 10.1159/000533865 [doi] PST - ppublish SO - Ophthalmic Res. 2023;66(1):1406-1416. doi: 10.1159/000533865. Epub 2023 Nov 4.