PMID- 37926141
OWN - NLM
STAT- MEDLINE
DCOM- 20240408
LR  - 20240426
IS  - 1615-5947 (Electronic)
IS  - 0890-5096 (Linking)
VI  - 102
DP  - 2024 May
TI  - Postoperative Myocardial Injury and Inflammatory Biomarkers in Patients 
      Undergoing Vascular Surgery: A Subanalysis of the Platelet Reactivity and 
      Postoperative Myocardial Injury after Major Vascular Surgery (PROMISE) Study.
PG  - 202-208
LID - S0890-5096(23)00751-3 [pii]
LID - 10.1016/j.avsg.2023.09.092 [doi]
AB  - BACKGROUND: Postoperative myocardial injury (PMI) is associated with morbidity 
      and mortality, but the aetiology remains unclear. We studied whether PMI is 
      associated with perioperative systemic inflammation. The objective is the 
      examination of the relationship between inflammatory biomarkers (Interleukin 
      6[IL-6], C-reactive protein [CRP]) and PMI, detected by elevated cardiac troponin 
      (cTn), in patients undergoing elective open abdominal aortic surgery. METHODS: 
      This prospective, single-center, observational cohort study included 54 patients 
      undergoing elective open abdominal aortic surgery between March 2018 and April 
      2021. Patients were routinely treated with aspirin. IL-6 and CRP were measured 
      preoperatively, directly after surgery, 24 hr and 48 hr postoperatively. The 
      primary outcome was cTn release assessed by a fifth-generation high-sensitive cTn 
      assay. Multivariable generalized linear regression models were used to evaluate 
      the association between inflammatory biomarkers and cTn concentrations. RESULTS: 
      Fifteen patients (27.8%) developed PMI. IL-6 directly and 24 hr postoperatively 
      was associated with elevated cTn concentrations (1.28 [1.07-1.54], P = 0.009) and 
      1.75 [1.18-2.59], P = 0.006, respectively). Also, CRP directly and 24 hr 
      postoperatively was associated with elevated cTn concentrations (1.25 
      [1.06-1.47], P = 0.009) and 1.61 [1.1-2.33], P = 0.013, respectively). No 
      association was found between IL-6 or CRP and cTn concentrations when measured at 
      48 hr postsurgery. CONCLUSIONS: Biomarkers of inflammation are associated with 
      elevated postoperative cTn concentrations in the early postoperative period in 
      patients undergoing elective open abdominal aortic surgery.
CI  - Copyright (c) 2023 Elsevier Inc. All rights reserved.
FAU - Zheng, Kailiang
AU  - Zheng K
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Bor, Willem L
AU  - Bor WL
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Kelder, Johannes C
AU  - Kelder JC
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Hackeng, Chris M
AU  - Hackeng CM
AD  - Department of Clinical Chemistry, St. Antonius Hospital, Nieuwegein, the 
      Netherlands.
FAU - Kropman, Rogier H J
AU  - Kropman RHJ
AD  - Department of Surgery, St. Antonius Hospital, Nieuwegein, the Netherlands.
FAU - Ten Berg, Jurrien M
AU  - Ten Berg JM
AD  - Department of Cardiology, St. Antonius Hospital, Nieuwegein, the Netherlands; 
      University Medical Centre Maastricht, Maastricht University, Maastricht, the 
      Netherlands.
FAU - Noordzij, Peter G
AU  - Noordzij PG
AD  - Department of Anaesthesiology, Intensive Care and Pain Medicine, St. Antonius 
      Hospital, Nieuwegein, the Netherlands; Department of Anaesthesiology, Intensive 
      Care and Pain medicine, University Medical Centre, Utrecht, the Netherlands. 
      Electronic address: p.noordzij@antoniusziekenhuis.nl.
LA  - eng
PT  - Journal Article
PT  - Observational Study
DEP - 20231104
PL  - Netherlands
TA  - Ann Vasc Surg
JT  - Annals of vascular surgery
JID - 8703941
RN  - 0 (Interleukin-6)
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Humans
MH  - Prospective Studies
MH  - *Interleukin-6
MH  - Treatment Outcome
MH  - Postoperative Complications/diagnosis/etiology
MH  - Vascular Surgical Procedures/adverse effects
MH  - Biomarkers
MH  - C-Reactive Protein
MH  - *Heart Injuries/diagnosis/etiology
MH  - Inflammation/diagnosis/etiology
MH  - Postoperative Period
EDAT- 2023/11/06 00:41
MHDA- 2024/04/08 06:44
CRDT- 2023/11/05 19:12
PHST- 2023/04/21 00:00 [received]
PHST- 2023/06/12 00:00 [revised]
PHST- 2023/09/20 00:00 [accepted]
PHST- 2024/04/08 06:44 [medline]
PHST- 2023/11/06 00:41 [pubmed]
PHST- 2023/11/05 19:12 [entrez]
AID - S0890-5096(23)00751-3 [pii]
AID - 10.1016/j.avsg.2023.09.092 [doi]
PST - ppublish
SO  - Ann Vasc Surg. 2024 May;102:202-208. doi: 10.1016/j.avsg.2023.09.092. Epub 2023 
      Nov 4.