PMID- 37926333
OWN - NLM
STAT- MEDLINE
DCOM- 20231129
LR  - 20231227
IS  - 1872-7549 (Electronic)
IS  - 0166-4328 (Linking)
VI  - 458
DP  - 2024 Feb 26
TI  - N-acetylcysteine ameliorates chemotherapy-induced impaired anxiety and 
      depression-like behaviors by regulating inflammation, oxidative and cholinergic 
      status, and BDNF release.
PG  - 114740
LID - S0166-4328(23)00458-8 [pii]
LID - 10.1016/j.bbr.2023.114740 [doi]
AB  - Mood disorders caused by chemotherapy have become more important as the survival 
      of cancer patients increases, and new studies in this field will contribute to 
      the prevention of this disorder. For this purpose, we used methotrexate, a 
      chemotherapeutic agent frequently preferred in oncological cases. Mtx was 
      administered as a single dose of 100 mg/kg intraperitoneally to male Wistar 
      albino rats. Since oxidative stress plays an important role in 
      chemotherapy-induced emotional impairment, n-acetylcysteine (NAC), a potent 
      antioxidant, was administered at 500 mg/kg in two doses before Mtx 
      administration. We evaluated anxiety and depression-like behaviors 24 h after Mtx 
      administration, as well as some oxidative and inflammatory markers in blood serum 
      and hippocampal tissue, acetylcholinesterase activity (AChE), and brain-derived 
      neurotrophic factor (BDNF) release in hippocampal tissue. In rats, Mtx induced 
      anxiety and depression-like behaviors as well as abnormalities in oxidative and 
      inflammatory markers in blood serum and hippocampal tissue, increased AChE 
      activity in hippocampal tissue, and decreased BDNF release. NAC treatment was 
      found to ameliorate Mtx-induced anxiety and depression-like behaviors, increase 
      antioxidant capacity, reduce oxidative stress and inflammatory response, and 
      regulate AChE activity and BDNF release. In conclusion, the fact that NAC 
      treatment of Mtx was effective is important for revising the treatment strategies 
      for individuals suffering from this disorder, and this effect is thought to be 
      related to the antioxidant and anti-inflammatory power of NAC.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Aslanlar, Durmus Ali
AU  - Aslanlar DA
AD  - Necmettin Erbakan University, Faculty of Medicine, Department of Medical 
      Pharmacology, Konya, Turkiye.
FAU - Visneci, Emin Fatih
AU  - Visneci EF
AD  - Health Ministry of Turkish Rebublic, Konya City Hospital, Department of Emergency 
      Medicine, Konya, Turkiye.
FAU - Oz, Mehmet
AU  - Oz M
AD  - Aksaray University, Faculty of Medicine, Department of Physiology, Aksaray, 
      Turkiye. Electronic address: ozmhmt@gmail.com.
FAU - Nurullahoglu Atalik, K Esra
AU  - Nurullahoglu Atalik KE
AD  - Necmettin Erbakan University, Faculty of Medicine, Department of Medical 
      Pharmacology, Konya, Turkiye.
LA  - eng
PT  - Journal Article
DEP - 20231104
PL  - Netherlands
TA  - Behav Brain Res
JT  - Behavioural brain research
JID - 8004872
RN  - WYQ7N0BPYC (Acetylcysteine)
RN  - 0 (Antioxidants)
RN  - 0 (Brain-Derived Neurotrophic Factor)
RN  - EC 3.1.1.7 (Acetylcholinesterase)
RN  - YL5FZ2Y5U1 (Methotrexate)
RN  - 0 (Antineoplastic Agents)
RN  - 0 (Cholinergic Agents)
SB  - IM
MH  - Rats
MH  - Humans
MH  - Male
MH  - Animals
MH  - *Acetylcysteine/pharmacology
MH  - Antioxidants/pharmacology/therapeutic use
MH  - Brain-Derived Neurotrophic Factor
MH  - Rats, Wistar
MH  - Depression/chemically induced/drug therapy
MH  - Acetylcholinesterase
MH  - Methotrexate
MH  - Oxidative Stress
MH  - Inflammation/chemically induced/drug therapy
MH  - Anxiety/chemically induced/drug therapy
MH  - *Antineoplastic Agents/pharmacology
MH  - Cholinergic Agents/pharmacology
OTO - NOTNLM
OT  - Anxiety
OT  - Depression
OT  - Inflammation
OT  - Methotrexate
OT  - N-acetylcysteine
OT  - Oxidative stress
EDAT- 2023/11/06 00:41
MHDA- 2023/11/29 06:42
CRDT- 2023/11/05 19:16
PHST- 2023/08/14 00:00 [received]
PHST- 2023/10/18 00:00 [revised]
PHST- 2023/11/01 00:00 [accepted]
PHST- 2023/11/29 06:42 [medline]
PHST- 2023/11/06 00:41 [pubmed]
PHST- 2023/11/05 19:16 [entrez]
AID - S0166-4328(23)00458-8 [pii]
AID - 10.1016/j.bbr.2023.114740 [doi]
PST - ppublish
SO  - Behav Brain Res. 2024 Feb 26;458:114740. doi: 10.1016/j.bbr.2023.114740. Epub 
      2023 Nov 4.