PMID- 37927082
OWN - NLM
STAT- MEDLINE
DCOM- 20231221
LR  - 20231231
IS  - 1475-2727 (Electronic)
IS  - 1368-9800 (Print)
IS  - 1368-9800 (Linking)
VI  - 26
IP  - 12
DP  - 2023 Dec
TI  - The relationship between nut consumption and premature coronary artery disease in 
      a representative sample of Iranians: Iran-premature coronary artery disease 
      (IPAD) study.
PG  - 2771-2779
LID - 10.1017/S1368980023002392 [doi]
AB  - OBJECTIVE: The cardioprotective effects of nuts are well established. However, 
      the positive impacts of nuts in preventing CVD at a younger age, a condition 
      known as premature coronary artery disease (PCAD), is still debated. Therefore, 
      we aim to determine the association between nuts and PCAD occurrence and its 
      severity in different Iranian ethnicities. DESIGN: This case-control study was 
      conducted within the framework of the Iran-premature coronary artery disease 
      (I-PAD) study, an ongoing multi-centric study on Iranian patients of different 
      ethnicities. SETTING: This multi-centric case-control study was conducted in 
      among 3253 persons under the age of 70 years in women and 60 years in men from 
      different ethnicities in Iran. PARTICIPANTS: Information on nut consumption was 
      collected using a validated FFQ. Subjects were selected from among the candidates 
      for angiography. Cases were those whose coronary angiography showed stenosis of 
      more than 75 % in at least one vessel or more than 50 % of the left main artery, 
      while the control group participants had normal angiography results. RESULTS: In 
      the crude model, compared to the first quartile, the highest quartile of nut 
      consumption was significantly associated with a lower risk of PCAD (OR = 0.26, 95 
      % CI (0.21, 0.32); P(for trend) = 0.001). In the top quartile of nut intake, a 
      substantial decrease in PCAD was observed after controlling for putative 
      confounders (OR = 0.32; 95 % CI (0.24, 0.43); P(for trend) = 0.001). 
      Additionally, a 75 % decrease in the risk of severe PCAD was observed in the 
      participants in the highest quartile of nut intake. CONCLUSION: A significant 
      inverse association was observed between nut intake and the risk and severity of 
      PCAD in the Iranian population. Large-scale clinical trials are required to 
      confirm these findings.
FAU - Mohammadifard, Noushin
AU  - Mohammadifard N
AUID- ORCID: 0000-0003-1776-1060
AD  - Interventional Cardiology Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Alavi Tabatabaei, Ghazaal
AU  - Alavi Tabatabaei G
AD  - Interventional Cardiology Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Haghighatdoost, Fahimeh
AU  - Haghighatdoost F
AUID- ORCID: 0000-0003-4766-6267
AD  - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Zarepur, Ehsan
AU  - Zarepur E
AD  - Interventional Cardiology Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
AD  - Department of Cardiology, Medicine School, Isfahan University of Medical 
      Sciences, Isfahan, Iran.
FAU - Nouri, Fatemeh
AU  - Nouri F
AD  - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Javanbakht, Sahel
AU  - Javanbakht S
AD  - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
FAU - Nouhi, Fereidoon
AU  - Nouhi F
AD  - Rajaie Cardiovascular Medical and Research Center, Iran University of Medical 
      Sciences, Tehran, Iran & President of Iranian Network of Cardiovascular Research 
      (INCVR).
AD  - Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
AD  - Iranian Network of Cardiovascular Research.
FAU - Alikhasi, Hassan
AU  - Alikhasi H
AD  - Heart Failure Research Center, Isfahan Cardiovascular Research Institute, Isfahan 
      University of Medical Sciences, Isfahan, Iran.
FAU - Kazemi, Tooba
AU  - Kazemi T
AD  - Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, 
      Birjand, Iran.
AD  - Clinical Research Development Unit, Imam Reza Hospital, Birjand University of 
      Medical Sciences, Birjand, Iran.
FAU - Azdaki, Nahid
AU  - Azdaki N
AD  - Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, 
      Birjand, Iran.
AD  - Clinical Research Development Unit, Imam Reza Hospital, Birjand University of 
      Medical Sciences, Birjand, Iran.
FAU - Salehi, Nahid
AU  - Salehi N
AD  - Cardiovascular Research Center, Health Institute, Kermanshah University of 
      Medical Sciences, Kermanshah, Iran.
FAU - Solati, Kamal
AU  - Solati K
AD  - Department of Psychiatry, Shahrekord University of Medical Sciences, Shahrekord, 
      Iran.
FAU - Lotfizadeh, Masoud
AU  - Lotfizadeh M
AD  - Social Determinants of Health Research Center, Shahrekord University of Medical 
      Sciences, Iran.
FAU - Ghaffari, Samad
AU  - Ghaffari S
AD  - Cardiovascular Research Center, Tabriz University of Medical Sciences, Tabriz, 
      Iran & Member of the INCVR.
FAU - Javanmardi, Elmira
AU  - Javanmardi E
AD  - Department of Cardiovascular Medicine, Heart Center, Maragheh University of 
      Medical Sciences, Amiralmomenin Hospital, Iran.
FAU - Salari, Arsalan
AU  - Salari A
AD  - Department of Cardiology, Healthy Heart Research Center, Heshmat Hospital, School 
      of Medicine, Guilan University of Medical Sciences, Rasht, Iran.
FAU - Dehghani, Mostafa
AU  - Dehghani M
AD  - Department of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan 
      University of Medical Science, Khorramabad, Iran.
FAU - Cheraghi, Mostafa
AU  - Cheraghi M
AD  - Department of Cardiovascular Research Center, Shahid Rahimi Hospital, Lorestan 
      University of Medical Science, Khorramabad, Iran.
FAU - Assareh, Ahmadreza
AU  - Assareh A
AD  - Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran & Member of the INCVR.
FAU - Haybar, Habib
AU  - Haybar H
AD  - Atherosclerosis Research Center, Ahvaz Jundishapur University of Medical 
      Sciences, Ahvaz, Iran & Member of the INCVR.
FAU - Namayandeh, Seyedeh Mahdieh
AU  - Namayandeh SM
AD  - Yazd Cardiovascular Research Center, Shahid Sadoughi University of Medical 
      Science, Yazd, Iran.
FAU - Madadi, Reza
AU  - Madadi R
AD  - Department of Cardiology, School of Medicine, Zanjan University of Medical 
      Sciences, Zanjan, Iran.
FAU - Sarrafzadegan, Nizal
AU  - Sarrafzadegan N
AD  - Isfahan Cardiovascular Research Center, Cardiovascular Research Institute, 
      Isfahan University of Medical Sciences, Isfahan, Iran.
AD  - Faculty of Medicine, School of Population and Public Health, University of 
      British Columbia, Vancouver, Canada.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20231106
PL  - England
TA  - Public Health Nutr
JT  - Public health nutrition
JID - 9808463
RN  - Iranian people
SB  - IM
MH  - Aged
MH  - Female
MH  - Humans
MH  - Male
MH  - Case-Control Studies
MH  - *Coronary Artery Disease/epidemiology/prevention & control
MH  - Iran/epidemiology
MH  - *Nuts
MH  - Risk Factors
MH  - Middle Aged
MH  - Diet
PMC - PMC10755431
OTO - NOTNLM
OT  - Ethnic group
OT  - Iran
OT  - Nuts
OT  - Premature coronary artery disease
COIS- There are no conflicts of interest.
EDAT- 2023/11/06 06:42
MHDA- 2023/12/21 06:43
PMCR- 2023/12/01
CRDT- 2023/11/06 03:41
PHST- 2023/12/21 06:43 [medline]
PHST- 2023/11/06 06:42 [pubmed]
PHST- 2023/11/06 03:41 [entrez]
PHST- 2023/12/01 00:00 [pmc-release]
AID - S1368980023002392 [pii]
AID - 10.1017/S1368980023002392 [doi]
PST - ppublish
SO  - Public Health Nutr. 2023 Dec;26(12):2771-2779. doi: 10.1017/S1368980023002392. 
      Epub 2023 Nov 6.