PMID- 37927108 OWN - NLM STAT- MEDLINE DCOM- 20231121 LR - 20231121 IS - 1096-9071 (Electronic) IS - 0146-6615 (Linking) VI - 95 IP - 11 DP - 2023 Nov TI - IL7RA rs10491434 polymorphism is related to spontaneous HIV infection control in naive HIV-infected patients: A retrospective study. PG - e29214 LID - 10.1002/jmv.29214 [doi] AB - Interleukin 7 receptor (IL7R) is vital in the adaptive immune response against human immunodeficiency viruses (HIV). We assessed IL7RA polymorphisms (SNPs) in antiretroviral therapy (ART)-naive HIV patients for their association with spontaneous HIV infection control. We conducted a retrospective cohort study involving 667 ART-naive patients categorized by HIV progression (ordinal variable): 150 rapid progressors, 334 moderate/typical progressors, 86 long-term nonprogressors elite controllers (LTNPs-EC), and 97 LTNPs-non-EC. We genotyped three IL7RA SNPs using Agena Bioscience's MassARRAY platform. The association between IL7RA SNPs and spontaneous HIV infection control was evaluated using ordinal logistic regression. Individuals carrying the rs10491434 G allele have a higher likelihood of spontaneous HIV infection control (adjusted odds ratio [aOR] = 1.33; p = 0.023). Moreover, the IL7RA GCT haplotype, consisting of three specific SNPs (rs6897932, rs987106, and rs10491434), demonstrated an association with the control of untreated HIV infection (aOR = 1.34; p = 0.050). Remarkably, the rs10491434 SNP and the IL7RA GCT haplotype exhibited similar aOR values, suggesting that rs10491434 may be primarily responsible for the observed effect of the haplotype. IL7RA rs10491434 G allele is associated with a higher likelihood of spontaneous HIV infection control, indicating its significant role in the pathogenesis of HIV, possibly influencing infection course and viral replication control. CI - (c) 2023 Wiley Periodicals LLC. FAU - Sepulveda-Crespo, Daniel AU - Sepulveda-Crespo D AD - Unidad de Infeccion Viral e Inmunidad, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain, Madrid, Spain. AD - Centro de Investigacion Biomedica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. FAU - Jimenez-Sousa, Maria A AU - Jimenez-Sousa MA AD - Unidad de Infeccion Viral e Inmunidad, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain, Madrid, Spain. AD - Centro de Investigacion Biomedica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. FAU - Fernandez-Rodiguez, Amanda AU - Fernandez-Rodiguez A AUID- ORCID: 0000-0002-5110-2213 AD - Unidad de Infeccion Viral e Inmunidad, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain, Madrid, Spain. AD - Centro de Investigacion Biomedica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. FAU - Munoz-Fernandez, Maria A AU - Munoz-Fernandez MA AD - Servicio de Inmunologia, Laboratorio InmunoBiologia Molecular, Hospital General Universitario Gregorio Maranon, Madrid, Spain. AD - Centro de Investigacion Biomedica en Red de Bioingenieria, Biomateriales y Nanomedicina (CIBER-BBN), Instituto de Salud Carlos III, Madrid, Spain. AD - Fundacion para la Investigacion Biomedica, Hospital General Universitario Gregorio Maranon, Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Madrid, Spain. FAU - Jimenez, Jose L AU - Jimenez JL AD - Fundacion para la Investigacion Biomedica, Hospital General Universitario Gregorio Maranon, Instituto de Investigacion Sanitaria Gregorio Maranon (IiSGM), Madrid, Spain. AD - Plataforma de Laboratorio, Hospital General Universitario "Gregorio Maranon", Madrid, Spain. FAU - Caraciolo, Begona B AU - Caraciolo BB AD - Centro Sanitario Sandoval, Instituto de Investigacion Sanitaria San Carlos (IdISSC), Hospital Clinico San Carlos, Madrid, Spain. FAU - Reus Banuls, Sergio AU - Reus Banuls S AD - Enfermedades Infecciosas, Hospital General Universitario Dr. Balmis de Alicante, Spain. FAU - Vilchez, Helem AU - Vilchez H AD - Unidad de Enfermedades Infecciosas, Servicio de Medicina Interna, Hospital Universitari Son Espases, Palma de Mallorca, Spain, Palma de Mallorca, Spain. FAU - Mothe, Beatriz AU - Mothe B AD - Centro de Investigacion Biomedica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. AD - Unidad de Enfermedades Infecciosas, IrsiCaixa Institut de Recerca de la Sida, Hospital Universitari Germans Trias i Pujol, Badalona. Spain, Badalona, Spain. FAU - Martinez, Isidoro AU - Martinez I AD - Unidad de Infeccion Viral e Inmunidad, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain, Madrid, Spain. AD - Centro de Investigacion Biomedica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. FAU - Benito, Jose M AU - Benito JM AD - HIV and Viral Hepatitis Research Laboratory, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), Madrid, Spain. AD - Hospital Universitario Rey Juan Carlos, Mostoles, Spain. FAU - Rallon, Norma AU - Rallon N AD - HIV and Viral Hepatitis Research Laboratory, Instituto de Investigacion Sanitaria Fundacion Jimenez Diaz, Universidad Autonoma de Madrid (IIS-FJD, UAM), Madrid, Spain. AD - Hospital Universitario Rey Juan Carlos, Mostoles, Spain. FAU - Resino, Salvador AU - Resino S AUID- ORCID: 0000-0001-8783-0450 AD - Unidad de Infeccion Viral e Inmunidad, Centro Nacional de Microbiologia, Instituto de Salud Carlos III, Madrid, Spain, Madrid, Spain. AD - Centro de Investigacion Biomedica en Red en Enfermedades Infecciosas (CIBERINFEC), Instituto de Salud Carlos III, Madrid, Spain. LA - eng PT - Journal Article PT - Research Support, Non-U.S. Gov't PL - United States TA - J Med Virol JT - Journal of medical virology JID - 7705876 RN - 0 (IL7R protein, human) RN - 0 (Interleukin-7 Receptor alpha Subunit) SB - IM MH - Humans MH - Disease Progression MH - *HIV Infections/genetics/therapy MH - Infection Control MH - Polymorphism, Single Nucleotide MH - Retrospective Studies MH - *Interleukin-7 Receptor alpha Subunit/genetics OTO - NOTNLM OT - HIV elite controllers OT - IL7 receptor OT - LTNPs OT - single nucleotide polymorphisms EDAT- 2023/11/06 06:42 MHDA- 2023/11/07 06:46 CRDT- 2023/11/06 03:42 PHST- 2023/09/12 00:00 [revised] PHST- 2023/07/27 00:00 [received] PHST- 2023/10/23 00:00 [accepted] PHST- 2023/11/07 06:46 [medline] PHST- 2023/11/06 06:42 [pubmed] PHST- 2023/11/06 03:42 [entrez] AID - 10.1002/jmv.29214 [doi] PST - ppublish SO - J Med Virol. 2023 Nov;95(11):e29214. doi: 10.1002/jmv.29214.