PMID- 37927265
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20240130
IS  - 1875-8908 (Electronic)
IS  - 1387-2877 (Linking)
VI  - 96
IP  - 3
DP  - 2023
TI  - Relationship Between Non-Cognitive Intrinsic Capacity and Activities of Daily 
      Living According to Alzheimer's Disease Stage.
PG  - 1115-1127
LID - 10.3233/JAD-230786 [doi]
AB  - BACKGROUND: Few studies have examined the relationship between non-cognitive 
      factors and activities of daily living (ADL) according to Alzheimer's disease 
      (AD) stage. OBJECTIVE: We aimed to identify the differences in non-cognitive 
      factors according to AD stages and their involvement in basic and instrumental 
      ADL performance by using intrinsic capacity (IC) in groups with cognition ranging 
      from normal to moderate or severe AD. METHODS: We enrolled 6397 patients aged>/=65 
      years who visited our memory clinic. Non-cognitive IC was assessed using the 
      locomotion, sensory, vitality, and psychological domains. Multiple logistic 
      regression was performed to identify how non-cognitive IC declines over the AD 
      course and examine the correlation between non-cognitive IC and basic and 
      instrumental ADL performance. RESULTS: Non-cognitive IC declined from the initial 
      AD stage and was significantly correlated with both basic and instrumental ADL 
      performance from the aMCI stage through all AD stages. In particular, the 
      relationship between IC and basic ADL was stronger in mild and moderate to severe 
      AD than in the aMCI stage. On the other hand, the relationship between IC and 
      instrumental ADL was stronger in aMCI than in later AD stages. CONCLUSIONS: The 
      results show non-cognitive factors, which decline from the aMCI stage, are 
      correlated with ADL performance from the aMCI stage to almost all AD stages. 
      Considering that the relationship strength varied by ADL type and AD stage, an 
      approach tailored to ADL type and AD stage targeting multiple risk factors is 
      likely needed for effectively preventing ADL performance declines.
FAU - Fujisawa, Chisato
AU  - Fujisawa C
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      Nagoya University, Nagoya, Japan.
AD  - Department of Prevention and Care Science, National Center for Geriatrics and 
      Gerontology, Obu, Japan.
FAU - Umegaki, Hiroyuki
AU  - Umegaki H
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      Nagoya University, Nagoya, Japan.
AD  - Institute of Innovation for Future Society Nagoya University, Nagoya, Japan.
FAU - Sugimoto, Taiki
AU  - Sugimoto T
AD  - Department of Prevention and Care Science, National Center for Geriatrics and 
      Gerontology, Obu, Japan.
FAU - Nakashima, Hirotaka
AU  - Nakashima H
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      Nagoya University, Nagoya, Japan.
FAU - Nagae, Masaaki
AU  - Nagae M
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      Nagoya University, Nagoya, Japan.
FAU - Komiya, Hitoshi
AU  - Komiya H
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      Nagoya University, Nagoya, Japan.
FAU - Watanabe, Kazuhisa
AU  - Watanabe K
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      Nagoya University, Nagoya, Japan.
FAU - Yamada, Yosuke
AU  - Yamada Y
AD  - Department of Community Healthcare and Geriatrics, Graduate School of Medicine, 
      Nagoya University, Nagoya, Japan.
FAU - Sakurai, Takashi
AU  - Sakurai T
AD  - Department of Prevention and Care Science, National Center for Geriatrics and 
      Gerontology, Obu, Japan.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - Netherlands
TA  - J Alzheimers Dis
JT  - Journal of Alzheimer's disease : JAD
JID - 9814863
SB  - IM
MH  - Humans
MH  - *Alzheimer Disease/psychology
MH  - Activities of Daily Living/psychology
MH  - Cognition
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - basic activities of daily living
OT  - instrumental activities of daily living
OT  - intrinsic capacity
EDAT- 2023/11/06 06:41
MHDA- 2023/11/27 12:44
CRDT- 2023/11/06 04:14
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/11/06 06:41 [pubmed]
PHST- 2023/11/06 04:14 [entrez]
AID - JAD230786 [pii]
AID - 10.3233/JAD-230786 [doi]
PST - ppublish
SO  - J Alzheimers Dis. 2023;96(3):1115-1127. doi: 10.3233/JAD-230786.