PMID- 37927719
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 10
DP  - 2023 Oct
TI  - Propofol-Related Infusion Syndrome: A Bibliometric Analysis of the 100 Most-Cited 
      Articles.
PG  - e46497
LID - 10.7759/cureus.46497 [doi]
LID - e46497
AB  - Propofol-related infusion syndrome (PRIS) is a rare, yet life-threatening 
      sequelae to prolonged administration of the anesthetic propofol in mechanically 
      intubated patients. The condition is characterized by progressive multi-system 
      organ failure and eventual mortality; of note, the predominant characteristics of 
      PRIS involve but are not limited to cardiovascular impairment and collapse, 
      metabolic and lactic acidosis, rhabdomyolysis, hyperkalemia, and acute renal 
      failure. While potent or extended doses of propofol have been found to be the 
      primary precipitating factor of this condition, others such as age, critical 
      illness, steroid therapy, and hyperlipidemia have been discovered to play a role 
      as well. This bibliometric analysis was done to reflect the current relevance and 
      understanding of PRIS in recent literature. The SCOPUS database was utilized to 
      conduct a search for articles with keywords "propofol infusion syndrome" and 
      "propofol syndrome" from February 24, 2001, until April 16, 2023, with parameters 
      for article title, citation number, citation per year, author, institution, 
      publishing journal, and country of origin. PRIS was first defined in 1990, just a 
      year after its approval by the Food and Drug Administration for use as a 
      sedative-hypnotic. Since then, interest in PRIS slowly rose up to 13 publications 
      per year in 2013. Seven papers on the topic were published in Critical Care 
      Medicine, six in Neurocritical Care, and four in Anesthesia. The most common 
      institutions were Mayo Clinic, Northeastern University, and Tufts Medical Center. 
      To our knowledge, this is the first bibliometric analysis to evaluate the most 
      influential publications about PRIS. A majority of the research is case-based, 
      possibly owing to the rarity of the condition. Our research suggests that 
      confounding factors outside the precipitating dosage of propofol may be 
      implicated in the onset and progression of PRIS. This study could therefore bring 
      renewed interest to the topic and lead to additional research focused on fully 
      understanding the pathophysiology of PRIS in order to promote the development of 
      novel diagnostics and treatment.
CI  - Copyright (c) 2023, Van et al.
FAU - Van, Sophie
AU  - Van S
AD  - Anesthesiology, California University of Science and Medicine, Colton, USA.
FAU - Lam, Vicky
AU  - Lam V
AD  - Anesthesiology, California University of Science and Medicine, Colton, USA.
FAU - Patel, Kisan
AU  - Patel K
AD  - Physical Medicine and Rehabilitation, California University of Science and 
      Medicine, Colton, USA.
FAU - Humphries, Andrew
AU  - Humphries A
AD  - Anesthesiology, California University of Science and Medicine, Colton, USA.
FAU - Siddiqi, Javed
AU  - Siddiqi J
AD  - Neurological Surgery, Riverside University Health System Medical Center, Moreno 
      Valley, USA.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231004
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10624560
OTO - NOTNLM
OT  - bibliometric analysis
OT  - medical publications
OT  - propofol infusion syndrome
OT  - propofol syndrome
OT  - systematic review and meta analysis
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/11/06 06:41
MHDA- 2023/11/06 06:42
PMCR- 2023/10/04
CRDT- 2023/11/06 04:22
PHST- 2023/09/05 00:00 [received]
PHST- 2023/10/04 00:00 [accepted]
PHST- 2023/11/06 06:42 [medline]
PHST- 2023/11/06 06:41 [pubmed]
PHST- 2023/11/06 04:22 [entrez]
PHST- 2023/10/04 00:00 [pmc-release]
AID - 10.7759/cureus.46497 [doi]
PST - epublish
SO  - Cureus. 2023 Oct 4;15(10):e46497. doi: 10.7759/cureus.46497. eCollection 2023 
      Oct.