PMID- 37928358
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 2296-2360 (Print)
IS  - 2296-2360 (Electronic)
IS  - 2296-2360 (Linking)
VI  - 11
DP  - 2023
TI  - Desmopressin in combination with anticholinergic agents in the treatment of 
      nocturnal enuresis: a systematic review and meta-analysis.
PG  - 1242777
LID - 10.3389/fped.2023.1242777 [doi]
LID - 1242777
AB  - BACKGROUND: The desmopressin combined with anticholinergic agents for the 
      treatment of nocturnal enuresis (NE) remains controversial. This meta-analysis 
      assesses the efficacy and safety of desmopressin compared with desmopressin plus 
      anticholinergic agents for the treatment of NE. METHODS: We searched MEDLINE, 
      Embase, and Cochrane Controlled Trials Register databases for RCTs published for 
      the treatment of NE. Systematic review was carried out using the Preferred 
      Reporting Items for Systematic Reviews and Meta-analyses. This meta-analysis used 
      RevMan v.5.1.0 to analyze data. RESULTS: Eight studies involving 600 patients 
      (293 in the combination group and 307 in the desmopressin group) contained 
      meaningful data. The results were as follows: after one month of treatment, 
      compared with the desmopressin monotherapy group, the combination group was 
      significantly better in treating NE in FR (full responders, P = 0.003), FR + PR 
      (partial responders) (P < 0.0001), and the mean number of wet nights (P = 0.004); 
      also, the combination group had a better effect in FR (P < 0.00001), FR + PR 
      (P = 0.02) and the mean number of wet nights (P = 0.04) after 3 months' 
      treatment. For side effects, combination therapy does not cause more adverse 
      events in treating NE (P = 0.42). CONCLUSIONS: This study elucidates that 
      desmopressin combined with the anticholinergic agent was demonstrated to be more 
      effective in treating NE than desmopressin monotherapy, and the anticholinergic 
      agent does not increase the risk of adverse events (AEs).
CI  - (c) 2023 Cai, Yao, Sun and Lei.
FAU - Cai, Tong
AU  - Cai T
AD  - Department of Urology, The Affiliated Hospital of Yangzhou University, Yangzhou 
      University, Yangzhou, China.
FAU - Yao, Yi
AU  - Yao Y
AD  - Department of Paediatrics, Yantai Yuhuangding Hospital, Yantai, China.
FAU - Sun, Weigui
AU  - Sun W
AD  - Department of Urology, The Affiliated Hospital of Yangzhou University, Yangzhou 
      University, Yangzhou, China.
FAU - Lei, Peipei
AU  - Lei P
AD  - Department of Endocrinology, Yantai Yuhuangding Hospital, Yantai, China.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231019
PL  - Switzerland
TA  - Front Pediatr
JT  - Frontiers in pediatrics
JID - 101615492
PMC - PMC10620680
OTO - NOTNLM
OT  - anticholinergic agent
OT  - desmopressin
OT  - meta-analysis
OT  - nocturnal enuresis (NE)
OT  - randomized controlled trials
COIS- The authors declare that the research was conducted in the absence of any 
      commercial or financial relationships that could be construed as a potential 
      conflict of interest.
EDAT- 2023/11/06 06:41
MHDA- 2023/11/06 06:42
PMCR- 2023/10/19
CRDT- 2023/11/06 04:32
PHST- 2023/06/19 00:00 [received]
PHST- 2023/09/21 00:00 [accepted]
PHST- 2023/11/06 06:42 [medline]
PHST- 2023/11/06 06:41 [pubmed]
PHST- 2023/11/06 04:32 [entrez]
PHST- 2023/10/19 00:00 [pmc-release]
AID - 10.3389/fped.2023.1242777 [doi]
PST - epublish
SO  - Front Pediatr. 2023 Oct 19;11:1242777. doi: 10.3389/fped.2023.1242777. 
      eCollection 2023.