PMID- 37929056
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231107
IS  - 1178-7007 (Print)
IS  - 1178-7007 (Electronic)
IS  - 1178-7007 (Linking)
VI  - 16
DP  - 2023
TI  - Association Between Serum Thyroid Measurements and Hyperhomocysteinemia in 
      Euthyroid Subjects: A Retrospective Cross-Sectional Study.
PG  - 3425-3433
LID - 10.2147/DMSO.S436381 [doi]
AB  - OBJECTIVE: The objective of this study was to investigate the association between 
      serum thyroid measurements and homocysteine (HCy) in euthyroid participants. 
      METHODS: This retrospective study was based on Hospital Information Systems. 
      After excluding participants with thyroid dysfunction and those who had recently 
      taken medications that affected serum HCy, 775 participants were enrolled. We 
      compared the serum thyroid function measurements of patients with or without 
      hyperhomocysteinemia (HHCy) and analyzed the effect of thyroid indicators on HHCy 
      prevalence and HCy levels. Multivariate regression analysis was utilized to 
      analyze the association of thyroid-stimulating hormone (TSH) and thyroid 
      peroxidase (TPOAb) with HCy. RESULTS: The serum TSH level (2.10 +/- 1.06 mIU/L) of 
      HHCy patients (n = 98) was significantly higher than controls (n = 677) (1.65 +/- 
      0.90 mIU/L) (p < 0.05), as was the positive rate of TPOAb (19.4% vs 10.0%, p < 
      0.05). The serum HCy levels in subjects with TSH within the highest quartile were 
      significantly higher than those in the lowest quartile (13.49 +/- 7.78 vs 9.81 +/- 
      3.59 mumol/L, p < 0.05). HCy was also significantly higher in TPOAb-positive 
      patients than in negative subjects (14.06 +/- 8.89 vs 11.48 +/- 5.47 mumol/L, p < 
      0.05). Among the TSH quartiles, the prevalence of HHCy showed a similar 
      significant upward trend to that described above. The prevalence of HHCy was also 
      significantly higher in TPOAb-positive patients. The results of multivariate 
      regression analysis suggested that both TSH elevation and TPOAb positivity were 
      independent risk factors for HCy elevation and HHCy prevalence. However, we found 
      no definitive association between linear increases in TPOAb titers and HCy 
      concentrations or HHCy prevalence. CONCLUSION: Patients with HHCy had 
      significantly higher TSH levels and positive rates of TPOAb. Elevated TSH and 
      positive TPOAb levels were independent risk factors for elevated HCy 
      concentrations and HHCy risk.
CI  - (c) 2023 Zou and Wang.
FAU - Zou, Jiayun
AU  - Zou J
AD  - Department of Thyroid Surgery, The First Hospital of China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
FAU - Wang, Yuhan
AU  - Wang Y
AUID- ORCID: 0009-0000-6809-6780
AD  - Department of Cardiovascular, The First Hospital of China Medical University, 
      Shenyang, Liaoning, People's Republic of China.
LA  - eng
PT  - Journal Article
DEP - 20231030
PL  - New Zealand
TA  - Diabetes Metab Syndr Obes
JT  - Diabetes, metabolic syndrome and obesity : targets and therapy
JID - 101515585
PMC - PMC10624187
OTO - NOTNLM
OT  - hyperhomocysteinemia
OT  - retrospective study
OT  - thyroid peroxidase antibody
OT  - thyroid stimulating hormone
COIS- The authors declare no conflict of interests.
EDAT- 2023/11/06 06:42
MHDA- 2023/11/06 06:43
PMCR- 2023/10/30
CRDT- 2023/11/06 04:46
PHST- 2023/08/21 00:00 [received]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2023/11/06 06:43 [medline]
PHST- 2023/11/06 06:42 [pubmed]
PHST- 2023/11/06 04:46 [entrez]
PHST- 2023/10/30 00:00 [pmc-release]
AID - 436381 [pii]
AID - 10.2147/DMSO.S436381 [doi]
PST - epublish
SO  - Diabetes Metab Syndr Obes. 2023 Oct 30;16:3425-3433. doi: 10.2147/DMSO.S436381. 
      eCollection 2023.