PMID- 37933321
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231108
IS  - 2168-8184 (Print)
IS  - 2168-8184 (Electronic)
IS  - 2168-8184 (Linking)
VI  - 15
IP  - 11
DP  - 2023 Nov
TI  - Coincidental Occurrence of Multiple Endocrine Neoplasia Type 1 and Breast Cancer 
      in a Young Saudi Girl: A Case Study and Genetic Analysis.
PG  - e48313
LID - 10.7759/cureus.48313 [doi]
LID - e48313
AB  - Multiple Endocrine Neoplasia Type 1 (MEN-1) is an autosomal dominant familial 
      disorder associated with tumors in both endocrine and non-endocrine organs. It is 
      uncommon for MEN-1 to coincide with breast cancer. We present a case of a 
      15-year-old Saudi girl who exhibited the classic symptoms of MEN-1 and 
      subsequently developed breast cancer. The patient's breast cancer was diagnosed 
      using ultrasonography and core biopsy, and she was treated with surgical 
      interventions. Despite these treatments, her cancer progressed to a metastatic 
      stage, and her overall health deteriorated, leading to cardiopulmonary arrest at 
      a young age. Although the simultaneous appearance of MEN-1 and breast cancer in 
      our patient may suggest a potential link, our comprehensive genetic analysis 
      found no relationship between her MEN-1 mutation and the onset of breast cancer. 
      This suggests that, in this case, the two conditions co-occurred by chance. 
      Nonetheless, additional research is needed to explore potential associations 
      between MEN-1 and breast cancer.
CI  - Copyright (c) 2023, Alhefdhi et al.
FAU - Alhefdhi, Amal
AU  - Alhefdhi A
AD  - Breast and Endocrine Surgery, King Faisal Specialist Hospital and Research 
      Centre, Riyadh, SAU.
FAU - Alrajhi, Reem S
AU  - Alrajhi RS
AD  - Medicine and Surgery, Alfaisal University College of Medicine, Riyadh, SAU.
FAU - Almady, Raghad A
AU  - Almady RA
AD  - Medicine and Surgery, Alfaisal University College of Medicine, Riyadh, SAU.
FAU - Alzahrani, Ali S
AU  - Alzahrani AS
AD  - Medicine, King Faisal Specialist Hospital and Research Centre, Riyadh, SAU.
LA  - eng
PT  - Case Reports
DEP - 20231105
PL  - United States
TA  - Cureus
JT  - Cureus
JID - 101596737
PMC - PMC10625808
OTO - NOTNLM
OT  - incidental breast cancer
OT  - multiple endocrine neoplasia type 1 (men-1)
OT  - riyadh
OT  - saudi arabia
OT  - young-onset breast cancer
COIS- The authors have declared that no competing interests exist.
EDAT- 2023/11/07 06:45
MHDA- 2023/11/07 06:46
PMCR- 2023/11/05
CRDT- 2023/11/07 03:48
PHST- 2023/11/05 00:00 [accepted]
PHST- 2023/11/07 06:46 [medline]
PHST- 2023/11/07 06:45 [pubmed]
PHST- 2023/11/07 03:48 [entrez]
PHST- 2023/11/05 00:00 [pmc-release]
AID - 10.7759/cureus.48313 [doi]
PST - epublish
SO  - Cureus. 2023 Nov 5;15(11):e48313. doi: 10.7759/cureus.48313. eCollection 2023 
      Nov.