PMID- 37933740
OWN - NLM
STAT- MEDLINE
DCOM- 20240228
LR  - 20240312
IS  - 1097-6817 (Electronic)
IS  - 0194-5998 (Linking)
VI  - 170
IP  - 3
DP  - 2024 Mar
TI  - Mucosal Microbiome Disruption in Acute Laryngeal Injury Following Intubation.
PG  - 977-980
LID - 10.1002/ohn.580 [doi]
AB  - The objective of this study was to characterize mucosal microbial shifts in 
      patients with acute laryngeal injury (ALgI) after intubation. This 
      cross-sectional study included 20 patients with ALgI who underwent early 
      endoscopic intervention with tissue culture, 20 patients with idiopathic 
      subglottic stenosis (iSGS) who underwent tissue culture during the routine 
      endoscopic intervention, and 3 control patients who underwent mucosal swab 
      culture. 70% of the ALgI patients had a positive culture compared to 5% of the 
      iSGS patients and none of the controls. The most identified microbes isolated 
      from ALgI patients included Staphylococcus species in 30% and Streptococcus 
      species in 25%. The high rate of pathologic bacterial infiltration into 
      postintubation laryngeal wounds supports efforts to reduce bacterial colonization 
      of endotracheal tubes and highlights the role of culture-directed antibiotic 
      therapy as a part of early intervention to improve outcomes for patients with 
      ALgI.
CI  - (c) 2023 American Academy of Otolaryngology-Head and Neck Surgery Foundation.
FAU - Davis, Ruth J
AU  - Davis RJ
AUID- ORCID: 0000-0001-9592-932X
AD  - Department of Otolaryngology-HNS, Vanderbilt University Medical Center, 
      Nashville, Tennessee, USA.
FAU - Shilts, Meghan H
AU  - Shilts MH
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee, USA.
FAU - Strickland, Britton A
AU  - Strickland BA
AD  - Department of Infectious Disease, Vanderbilt University Medical Center, 
      Nashville, Tennessee, USA.
FAU - Rajagopala, Seesandra V
AU  - Rajagopala SV
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee, USA.
FAU - Das, Suman R
AU  - Das SR
AD  - Department of Medicine, Vanderbilt University Medical Center, Nashville, 
      Tennessee, USA.
AD  - Department of Infectious Disease, Vanderbilt University Medical Center, 
      Nashville, Tennessee, USA.
FAU - Wootten, Christopher T
AU  - Wootten CT
AD  - Department of Otolaryngology-HNS, Vanderbilt University Medical Center, 
      Nashville, Tennessee, USA.
FAU - Gelbard, Alexander
AU  - Gelbard A
AD  - Department of Otolaryngology-HNS, Vanderbilt University Medical Center, 
      Nashville, Tennessee, USA.
LA  - eng
GR  - R01 HL146401/HL/NHLBI NIH HHS/United States
PT  - Journal Article
DEP - 20231107
PL  - England
TA  - Otolaryngol Head Neck Surg
JT  - Otolaryngology--head and neck surgery : official journal of American Academy of 
      Otolaryngology-Head and Neck Surgery
JID - 8508176
SB  - IM
MH  - Humans
MH  - Cross-Sectional Studies
MH  - *Laryngeal Diseases/etiology
MH  - *Laryngostenosis/etiology
MH  - Intubation, Intratracheal/adverse effects
MH  - *Microbiota
OTO - NOTNLM
OT  - acute laryngeal injury
OT  - microbiology
EDAT- 2023/11/07 12:47
MHDA- 2024/02/28 06:43
CRDT- 2023/11/07 07:03
PHST- 2023/05/17 00:00 [revised]
PHST- 2023/03/18 00:00 [received]
PHST- 2023/10/22 00:00 [accepted]
PHST- 2024/02/28 06:43 [medline]
PHST- 2023/11/07 12:47 [pubmed]
PHST- 2023/11/07 07:03 [entrez]
AID - 10.1002/ohn.580 [doi]
PST - ppublish
SO  - Otolaryngol Head Neck Surg. 2024 Mar;170(3):977-980. doi: 10.1002/ohn.580. Epub 
      2023 Nov 7.