PMID- 37934569
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231207
IS  - 1945-4589 (Electronic)
IS  - 1945-4589 (Linking)
VI  - 15
IP  - 21
DP  - 2023 Nov 6
TI  - Influences and mechanism of erythropoietin on the cognitive function of vascular 
      dementia rats.
PG  - 12264-12274
LID - 10.18632/aging.205178 [doi]
AB  - PURPOSE: To investigate the influences and mechanism of erythropoietin (EPO) on 
      the cognitive function of vascular dementia (VD) rats. METHODS: 1) Spatial memory 
      capacity was assessed by Morris water maze test; 2) Pathological conditions of 
      brain tissues were detected by hematoxylin-eosin (HE) staining; 3) The effect of 
      treatment on apoptosis was observed by terminal deoxynucleotidyl 
      transferase-mediated dUTP nick end labeling (TUNEL) staining; 4) Western blotting 
      was used to examine the protein expression in hippocampal neurons. RESULTS: The 
      escape latency and swimming distance in the EPO group were much shorter than 
      those in the Model group on the fifth day. In the spatial exploration test, the 
      time spent in the target quadrant was longer, the number of platform crossings 
      was larger and the swimming speed was higher in the Sham group and EPO group than 
      those in the Model group. The results of HE staining showed that the cells in the 
      hippocampal CA1 region were arranged closely in the Sham group, loosely and 
      disorderly in the Model group but significantly better in the EPO group. Compared 
      with that in the Model group, the number of apoptotic cells in the EPO group was 
      obviously smaller. The results of Western blotting revealed that the expressions 
      of EPO, p-EPOR, p-SHP2, p-TrKB, p-PI3K, p-ERK1/2 and Bcl-2 rose, while the 
      expressions of P22, P47, Caspase-3, Caspase-9 and Bax significantly declined in 
      the EPO group. CONCLUSIONS: EPO can effectively ameliorate the cognitive 
      dysfunction induced by chronic hypoperfusion in VD rats by mediating oxidative 
      stress-related pathways.
FAU - Tang, Zhipeng
AU  - Tang Z
AD  - Department of Neurology, Hebei Medical University, Shijiazhuang, Hebei, China.
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China.
FAU - Li, Xiuqin
AU  - Li X
AD  - Department of Geriatric Medicine, Hebei General Hospital, Shijiazhuang, Hebei, 
      China.
FAU - Yin, Nan
AU  - Yin N
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China.
FAU - Zhao, Ming
AU  - Zhao M
AD  - Department of Laboratory, Hebei General Hospital, Shijiazhuang, Hebei, China.
FAU - Hu, Qingchuan
AU  - Hu Q
AD  - Department of Laboratory, Hebei General Hospital, Shijiazhuang, Hebei, China.
FAU - Lv, Peiyuan
AU  - Lv P
AD  - Department of Neurology, Hebei Medical University, Shijiazhuang, Hebei, China.
AD  - Department of Neurology, Hebei General Hospital, Shijiazhuang, Hebei, China.
AD  - Department of Geriatric Medicine, Hebei General Hospital, Shijiazhuang, Hebei, 
      China.
AD  - Hebei Provincial Key Laboratory of Cerebral Networks and Cognitive Disorders, 
      Shijiazhuang, Hebei, China.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231106
PL  - United States
TA  - Aging (Albany NY)
JT  - Aging
JID - 101508617
RN  - 11096-26-7 (Erythropoietin)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Dementia, Vascular/drug therapy/metabolism
MH  - Rats, Sprague-Dawley
MH  - *Erythropoietin/pharmacology
MH  - Hippocampus/metabolism
MH  - Apoptosis
MH  - Cognition
PMC - PMC10683607
OTO - NOTNLM
OT  - cell apoptosis
OT  - erythropoietin
OT  - oxidative stress
OT  - vascular dementia
COIS- CONFLICTS OF INTEREST: The authors declare that they have no conflicts of 
      interest.
EDAT- 2023/11/07 12:47
MHDA- 2023/11/27 12:44
PMCR- 2023/11/15
CRDT- 2023/11/07 11:53
PHST- 2023/06/08 00:00 [received]
PHST- 2023/10/06 00:00 [accepted]
PHST- 2023/11/27 12:44 [medline]
PHST- 2023/11/07 12:47 [pubmed]
PHST- 2023/11/07 11:53 [entrez]
PHST- 2023/11/15 00:00 [pmc-release]
AID - 205178 [pii]
AID - 10.18632/aging.205178 [doi]
PST - ppublish
SO  - Aging (Albany NY). 2023 Nov 6;15(21):12264-12274. doi: 10.18632/aging.205178. 
      Epub 2023 Nov 6.