PMID- 37935073
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20240311
IS  - 1878-5905 (Electronic)
IS  - 0142-9612 (Linking)
VI  - 303
DP  - 2023 Dec
TI  - Safe and efficient oral allergy immunotherapy using one-pot-prepared 
      mannan-coated allergen nanoparticles.
PG  - 122381
LID - S0142-9612(23)00389-7 [pii]
LID - 10.1016/j.biomaterials.2023.122381 [doi]
AB  - Allergen immunotherapy (AIT) is the only curative treatment for allergic 
      diseases. However, AIT has many disadvantages related to efficiency, safety, 
      long-term duration, and patient compliance. Dendritic cells (DCs) have an 
      important role in antigen-specific tolerance induction; thus, DC-targeting 
      strategies to treat allergies such as glutaraldehyde crosslinked antigen to 
      mannoprotein (MAN) have been established. However, glutaraldehyde crosslinking 
      may reduce the antigen presentation efficiency of DCs. To overcome this, we 
      developed a MAN-coated ovalbumin (OVA) nanoparticle (MDO), which uses 
      intermolecular disulfide bond to crosslink OVA and MAN. MDO effectively targeted 
      DCs resulting in tolerogenic DCs, and promoted higher antigen presentation 
      efficiency by DCs compared with OVA or glutaraldehyde crosslinked nanoparticles. 
      In vitro and in vivo experiments showed that DCs exposed to MDO induced T(reg) 
      cells. Moreover, MDO had low reactivity with anti-OVA antibodies and did not 
      induce anaphylaxis in allergic mice, demonstrating its high safety profile. In a 
      mouse model of allergic asthma, MDO had significant preventative and therapeutic 
      effects when administered orally or subcutaneously. Therefore, MDO represents a 
      promising new approach for the efficient and safe treatment of allergies.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Li, Shunyi
AU  - Li S
AD  - Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, 819-0395, 
      Japan.
FAU - Toriumi, Hiroki
AU  - Toriumi H
AD  - Division of Biochemistry, Graduate School of Pharmaceutical Sciences, Keio 
      University, Tokyo, 105-8512, Japan.
FAU - Takahashi, Daisuke
AU  - Takahashi D
AD  - Division of Biochemistry, Faculty of Pharmacy and Graduate School of 
      Pharmaceutical Sciences, Keio University, Tokyo, 105-8512, Japan.
FAU - Kamasaki, Tomoko
AU  - Kamasaki T
AD  - Department of Cell Physiology, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, 060-8638, Japan.
FAU - Fujioka, Yoichiro
AU  - Fujioka Y
AD  - Department of Cell Physiology, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, 060-8638, Japan.
FAU - Nagatoishi, Satoru
AU  - Nagatoishi S
AD  - The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, 
      Japan; Department of Bioengineering, School of Engineering, The University of 
      Tokyo, Tokyo, 113-8656, Japan.
FAU - Li, Jinting
AU  - Li J
AD  - Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, 819-0395, 
      Japan.
FAU - Liu, Yiwei
AU  - Liu Y
AD  - Department of Applied Chemistry, Faculty of Engineering, Kyushu University, 
      Fukuoka, 819-0395, Japan.
FAU - Hosokawa, Takanatsu
AU  - Hosokawa T
AD  - Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, 819-0395, 
      Japan.
FAU - Tsumoto, Kouhei
AU  - Tsumoto K
AD  - The Institute of Medical Science, The University of Tokyo, Tokyo, 108-8639, 
      Japan; Department of Bioengineering, School of Engineering, The University of 
      Tokyo, Tokyo, 113-8656, Japan.
FAU - Ohba, Yusuke
AU  - Ohba Y
AD  - Department of Cell Physiology, Faculty of Medicine and Graduate School of 
      Medicine, Hokkaido University, Sapporo, 060-8638, Japan.
FAU - Katayama, Yoshiki
AU  - Katayama Y
AD  - Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, 819-0395, 
      Japan; Department of Applied Chemistry, Faculty of Engineering, Kyushu 
      University, Fukuoka, 819-0395, Japan; Center for Future Chemistry, Kyushu 
      University, Fukuoka, 819-0395, Japan; International Research Center for Molecular 
      Systems, Kyushu University, Fukuoka, 819-0395, Japan; Centre for Advanced 
      Medicine Innovation, Kyushu University, Fukuoka, 812-8582, Japan; Department of 
      Biomedical Engineering, Chung Yuan Christian University, Chung Li, 32023, Taiwan. 
      Electronic address: katayama.yoshiki.958@m.kyushu-u.ac.jp.
FAU - Murakami, Daisuke
AU  - Murakami D
AD  - Department of Otorhinolaryngology, Graduate School of Medical Sciences, Kyushu 
      University, Fukuoka, 812-8582, Japan. Electronic address: 
      murakami.daisuke.181@m.kyushu-u.ac.jp.
FAU - Hase, Koji
AU  - Hase K
AD  - Division of Biochemistry, Faculty of Pharmacy and Graduate School of 
      Pharmaceutical Sciences, Keio University, Tokyo, 105-8512, Japan; The Institute 
      of Fermentation Sciences (IFeS), Faculty of Food and Agricultural Sciences, 
      Fukushima University, Kanayagawa, Fukushima, 960-1296, Japan; International 
      Research and Development Centre for Mucosal Vaccines, The Institute of Medical 
      Science, The University of Tokyo (IMSUT), Tokyo, 108-8639, Japan. Electronic 
      address: hase-kj@pha.keio.ac.jp.
FAU - Mori, Takeshi
AU  - Mori T
AD  - Graduate School of Systems Life Sciences, Kyushu University, Fukuoka, 819-0395, 
      Japan; Department of Applied Chemistry, Faculty of Engineering, Kyushu 
      University, Fukuoka, 819-0395, Japan; Center for Future Chemistry, Kyushu 
      University, Fukuoka, 819-0395, Japan. Electronic address: 
      mori.takeshi.880@m.kyushu-u.ac.jp.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231031
PL  - Netherlands
TA  - Biomaterials
JT  - Biomaterials
JID - 8100316
RN  - 0 (Mannans)
RN  - T3C89M417N (Glutaral)
RN  - 0 (Allergens)
RN  - 9006-59-1 (Ovalbumin)
SB  - IM
MH  - Humans
MH  - Mice
MH  - Animals
MH  - Mannans
MH  - Glutaral
MH  - Dendritic Cells
MH  - *Hypersensitivity
MH  - Allergens
MH  - Desensitization, Immunologic
MH  - *Nanoparticles/chemistry
MH  - Ovalbumin
MH  - Immunotherapy/methods
OTO - NOTNLM
OT  - Allergen-specific immunotherapy
OT  - Dendritic cells
OT  - Mannan-coated allergen nanoparticle
OT  - Mannoprotein
OT  - Tolerance
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/07 18:42
MHDA- 2023/12/04 12:42
CRDT- 2023/11/07 18:00
PHST- 2023/03/07 00:00 [received]
PHST- 2023/08/16 00:00 [revised]
PHST- 2023/10/27 00:00 [accepted]
PHST- 2023/12/04 12:42 [medline]
PHST- 2023/11/07 18:42 [pubmed]
PHST- 2023/11/07 18:00 [entrez]
AID - S0142-9612(23)00389-7 [pii]
AID - 10.1016/j.biomaterials.2023.122381 [doi]
PST - ppublish
SO  - Biomaterials. 2023 Dec;303:122381. doi: 10.1016/j.biomaterials.2023.122381. Epub 
      2023 Oct 31.