PMID- 37935798
OWN - NLM
STAT- MEDLINE
DCOM- 20231216
LR  - 20231216
IS  - 1433-7347 (Electronic)
IS  - 0942-2056 (Print)
IS  - 0942-2056 (Linking)
VI  - 31
IP  - 12
DP  - 2023 Dec
TI  - Meniscal allograft transplantation improves patient-reported outcomes in both 
      minimal and moderate knee osteoarthritis at 1 and 2 years postoperatively.
PG  - 5765-5772
LID - 10.1007/s00167-023-07625-3 [doi]
AB  - PURPOSE: Severe cartilage damage and advanced knee osteoarthritis (OA) might be 
      associated with poor outcomes of meniscal allograft transplantation (MAT). The 
      purpose of this prospective follow-up study was to explore MAT survivorship and 
      patient satisfaction among young patients with symptomatic meniscal deficiency 
      and radiological OA of different Kellgren-Lawrence (K-L) grades. METHODS: 
      Thirty-five consecutive MAT patients were prospectively followed up for 2 years. 
      The lateral meniscus was replaced in 29 patients and the medial meniscus in 6 
      patients. Outcomes were assessed using the KOOS(4) composite score, KOOS 
      subscales, Lysholm knee score, and OA K-L grade progression from weight-bearing 
      knee radiographs. For the outcome analysis, patients were categorized into two 
      groups: 19 in Group A (K-L classification 0-1) and 16 in Group B (K-L 
      classification 2). RESULTS: In terms of KOOS(4) and Lysholm scores, the patients 
      showed a clinically significant improvement from baseline to the 1-year follow-up 
      (22.2 points, 95% CI 16.6-27.8 for KOOS(4) and 16.8 points, 95% CI 8.9-24.6 for 
      Lysholm), and the improvement remained at 2 years (20.6 points, 95% CI 13.2-28.1 
      for KOOS(4) and 21.5, 95% CI 12.5-30.7 for Lysholm). At the 6-month follow-up, 
      this improvement was not yet observed. Minor between-group differences were 
      observed in the KOOS(4) and Lysholm scores for the K-L 0-1 and K-L 2 OA groups, 
      but the estimates were imprecise with wide confidence intervals. A clinically 
      relevant difference between these two study groups could not be found at any 
      timepoint. The reoperation rate was higher in the K-L 2 group than in the K-L 0-1 
      group (31% vs. 11%). CONCLUSIONS: MAT yielded improved patient-reported outcomes 
      and subjective satisfaction at 1 and 2 years postoperatively. The differences 
      from baseline exceeded the minimal clinically important difference (MCID) at all 
      timepoints. The severity of cartilage damage and knee OA in terms of the K-L 
      grade at the time of surgery did not affect the KOOS and Lysholm scores after the 
      MAT procedure. Knee OA progression in terms of K-L grade worsening was not 
      observed in any patients. LEVEL OF EVIDENCE: III.
CI  - (c) 2023. The Author(s).
FAU - Aavikko, Anni
AU  - Aavikko A
AUID- ORCID: 0000-0002-8501-6735
AD  - Department of Surgery, Paijat-Hame Central Hospital, Lahti, Finland. 
      anni.aavikko@paijatha.fi.
AD  - University of Helsinki, Helsinki, Finland. anni.aavikko@paijatha.fi.
FAU - Bister, Ville
AU  - Bister V
AD  - Department of Surgery, Clinicum, Faculty of Medicine, University of Helsinki, 
      Helsinki, Finland.
FAU - Reito, Aleksi
AU  - Reito A
AD  - Department of Orthopaedics and Traumatology, Tampere University Hospital, 
      Tampere, Finland.
FAU - Lindahl, Jan
AU  - Lindahl J
AD  - Department of Orthopaedics and Traumatology, Helsinki University Hospital and 
      University of Helsinki, Helsinki, Finland.
LA  - eng
PT  - Journal Article
DEP - 20231107
PL  - Germany
TA  - Knee Surg Sports Traumatol Arthrosc
JT  - Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA
JID - 9314730
SB  - IM
MH  - Humans
MH  - *Osteoarthritis, Knee/surgery
MH  - Follow-Up Studies
MH  - Prospective Studies
MH  - Menisci, Tibial/surgery/transplantation
MH  - Patient Reported Outcome Measures
MH  - *Musculoskeletal Diseases
MH  - Allografts
PMC - PMC10719142
OTO - NOTNLM
OT  - Cartilage damage
OT  - Knee osteoarthritis
OT  - Meniscal allograft transplantation
OT  - Patient-reported outcomes
COIS- The authors have no conflicts of interest.
EDAT- 2023/11/08 00:41
MHDA- 2023/12/17 10:19
PMCR- 2023/11/07
CRDT- 2023/11/07 23:35
PHST- 2023/03/02 00:00 [received]
PHST- 2023/10/09 00:00 [accepted]
PHST- 2023/12/17 10:19 [medline]
PHST- 2023/11/08 00:41 [pubmed]
PHST- 2023/11/07 23:35 [entrez]
PHST- 2023/11/07 00:00 [pmc-release]
AID - 10.1007/s00167-023-07625-3 [pii]
AID - 7625 [pii]
AID - 10.1007/s00167-023-07625-3 [doi]
PST - ppublish
SO  - Knee Surg Sports Traumatol Arthrosc. 2023 Dec;31(12):5765-5772. doi: 
      10.1007/s00167-023-07625-3. Epub 2023 Nov 7.