PMID- 37935923 OWN - NLM STAT- MEDLINE DCOM- 20240328 LR - 20240331 IS - 1432-2161 (Electronic) IS - 0364-2348 (Print) IS - 0364-2348 (Linking) VI - 53 IP - 5 DP - 2024 May TI - High contrast cartilaginous endplate imaging in spine using three dimensional dual-inversion recovery prepared ultrashort echo time (3D DIR-UTE) sequence. PG - 881-890 LID - 10.1007/s00256-023-04503-4 [doi] AB - PURPOSE: To investigate the feasibility and application of a novel imaging technique, a three-dimensional dual adiabatic inversion recovery prepared ultrashort echo time (3D DIR-UTE) sequence, for high contrast assessment of cartilaginous endplate (CEP) imaging with head-to-head comparisons between other UTE imaging techniques. METHOD: The DIR-UTE sequence employs two narrow-band adiabatic full passage (AFP) pulses to suppress signals from long T(2) water (e.g., nucleus pulposus (NP)) and bone marrow fat (BMF) independently, followed by multispoke UTE acquisition to detect signals from the CEP with short T(2) relaxation times. The DIR-UTE sequence, in addition to three other UTE sequences namely, an IR-prepared and fat-saturated UTE (IR-FS-UTE), a T(1)-weighted and fat-saturated UTE sequence (T(1w)-FS-UTE), and a fat-saturated UTE (FS-UTE) was used for MR imaging on a 3 T scanner to image six asymptomatic volunteers, six patients with low back pain, as well as a human cadaveric specimen. The contrast-to-noise ratio of the CEP relative to the adjacent structures-specifically the NP and BMF-was then compared from the acquired images across the different UTE sequences. RESULTS: For asymptomatic volunteers, the DIR-UTE sequence showed significantly higher contrast-to-noise ratio values between the CEP and BMF (CNR(CEP-BMF)) (19.9 +/- 3.0) and between the CEP and NP (CNR(CEP-NP)) (23.1 +/- 1.7) compared to IR-FS-UTE (CNR(CEP-BMF): 17.3 +/- 1.2 and CNR(CEP-NP): 19.1 +/- 1.8), T(1w)-FS-UTE (CNR(CEP-BMF): 9.0 +/- 2.7 and CNR(CEP-NP): 10.4 +/- 3.5), and FS-UTE (CNR(CEP-BMF): 7.7 +/- 2.2 and CNR(CEP-NP): 5.8 +/- 2.4) for asymptomatic volunteers (all P-values < 0.001). For the spine sample and patients with low back pain, the DIR-UTE technique detected abnormalities such as irregularities and focal defects in the CEP regions. CONCLUSION: The 3D DIR-UTE sequence is able to provide high-contrast volumetric CEP imaging for human spines on a clinical 3 T scanner. CI - (c) 2023. The Author(s). FAU - Athertya, Jiyo S AU - Athertya JS AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. FAU - Lo, James AU - Lo J AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. AD - Department of Bioengineering, University of California San Diego, San Diego, CA, USA. FAU - Chen, Xiaojun AU - Chen X AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. FAU - Shin, Soo Hyun AU - Shin SH AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. FAU - Malhi, Bhavsimran Singh AU - Malhi BS AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. FAU - Jerban, Saeed AU - Jerban S AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. FAU - Ji, Yang AU - Ji Y AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. FAU - Sedaghat, Sam AU - Sedaghat S AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. FAU - Yoshioka, Hiroshi AU - Yoshioka H AD - Department of Radiological Sciences, University of California Irvine, Irvine, CA, USA. FAU - Du, Jiang AU - Du J AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. AD - Department of Bioengineering, University of California San Diego, San Diego, CA, USA. AD - Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. FAU - Guma, Monica AU - Guma M AD - Department of Medicine, University of California San Diego, San Diego, CA, USA. AD - Medicine Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. FAU - Chang, Eric Y AU - Chang EY AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. AD - Radiology Service, Veterans Affairs San Diego Healthcare System, San Diego, CA, USA. FAU - Ma, Yajun AU - Ma Y AD - Department of Radiology, University of California San Diego, San Diego, CA, USA. yam013@health.ucsd.edu. LA - eng GR - R01 AR068987/AR/NIAMS NIH HHS/United States GR - K01AR080257/GF/NIH HHS/United States GR - R21 AR075851/AR/NIAMS NIH HHS/United States GR - T32 AR007581/AR/NIAMS NIH HHS/United States GR - R01AR075825/GF/NIH HHS/United States GR - F32 AG082458/AG/NIA NIH HHS/United States GR - R01 AR062581/AR/NIAMS NIH HHS/United States GR - R01AR068987/GF/NIH HHS/United States GR - I01 CX001388/CX/CSRD VA/United States GR - R01AR079484/GF/NIH HHS/United States GR - I01 RX002604/RX/RRD VA/United States GR - R01 AR075825/AR/NIAMS NIH HHS/United States GR - R21AR07581/GF/NIH HHS/United States GR - R01 AR079484/AR/NIAMS NIH HHS/United States GR - F32AG082458/GF/NIH HHS/United States GR - K01 AR080257/AR/NIAMS NIH HHS/United States GR - R01AR062581/GF/NIH HHS/United States PT - Journal Article DEP - 20231108 PL - Germany TA - Skeletal Radiol JT - Skeletal radiology JID - 7701953 SB - IM MH - Humans MH - *Low Back Pain MH - Bone and Bones MH - Magnetic Resonance Imaging/methods MH - Cartilage MH - Phantoms, Imaging MH - Imaging, Three-Dimensional/methods PMC - PMC10973042 MID - NIHMS1950526 OTO - NOTNLM OT - Cartilaginous endplate OT - Dual adiabatic inversion recovery OT - High contrast OT - Low back pain OT - UTE COIS- The authors have no conflicts of interest to declare. EDAT- 2023/11/08 00:42 MHDA- 2024/03/28 06:45 PMCR- 2023/11/08 CRDT- 2023/11/07 23:45 PHST- 2023/07/17 00:00 [received] PHST- 2023/10/29 00:00 [accepted] PHST- 2023/10/14 00:00 [revised] PHST- 2024/03/28 06:45 [medline] PHST- 2023/11/08 00:42 [pubmed] PHST- 2023/11/07 23:45 [entrez] PHST- 2023/11/08 00:00 [pmc-release] AID - 10.1007/s00256-023-04503-4 [pii] AID - 4503 [pii] AID - 10.1007/s00256-023-04503-4 [doi] PST - ppublish SO - Skeletal Radiol. 2024 May;53(5):881-890. doi: 10.1007/s00256-023-04503-4. Epub 2023 Nov 8.