PMID- 37936020
OWN - NLM
STAT- MEDLINE
DCOM- 20231207
LR  - 20240423
IS  - 1534-4681 (Electronic)
IS  - 1068-9265 (Linking)
VI  - 31
IP  - 1
DP  - 2024 Jan
TI  - Impact of Liver Cirrhosis, Severity of Cirrhosis, and Portal Hypertension on the 
      Difficulty and Outcomes of Laparoscopic and Robotic Major Liver Resections for 
      Primary Liver Malignancies.
PG  - 97-114
LID - 10.1245/s10434-023-14376-5 [doi]
AB  - BACKGROUND: Minimally invasive liver resections (MILR) offer potential benefits 
      such as reduced blood loss and morbidity compared with open liver resections. 
      Several studies have suggested that the impact of cirrhosis differs according to 
      the extent and complexity of resection. Our aim was to investigate the impact of 
      cirrhosis on the difficulty and outcomes of MILR, focusing on major 
      hepatectomies. METHODS: A total of 2534 patients undergoing minimally invasive 
      major hepatectomies (MIMH) for primary malignancies across 58 centers worldwide 
      were retrospectively reviewed. Propensity score (PSM) and coarsened exact 
      matching (CEM) were used to compare patients with and without cirrhosis. RESULTS: 
      A total of 1353 patients (53%) had no cirrhosis, 1065 (42%) had Child-Pugh A and 
      116 (4%) had Child-Pugh B cirrhosis. Matched comparison between non-cirrhotics vs 
      Child-Pugh A cirrhosis demonstrated comparable blood loss. However, after PSM, 
      postoperative morbidity and length of hospitalization was significantly greater 
      in Child-Pugh A cirrhosis, but these were not statistically significant with CEM. 
      Comparison between Child-Pugh A and Child-Pugh B cirrhosis demonstrated the 
      latter had significantly higher transfusion rates and longer hospitalization 
      after PSM, but not after CEM. Comparison of patients with cirrhosis of all grades 
      with and without portal hypertension demonstrated no significant difference in 
      all major perioperative outcomes after PSM and CEM. CONCLUSIONS: The presence and 
      severity of cirrhosis affected the difficulty and impacted the outcomes of MIMH, 
      resulting in higher blood transfusion rates, increased postoperative morbidity, 
      and longer hospitalization in patients with more advanced cirrhosis. As such, 
      future difficulty scoring systems for MIMH should incorporate liver cirrhosis and 
      its severity as variables.
CI  - (c) 2023. Society of Surgical Oncology.
FAU - Cipriani, Federica
AU  - Cipriani F
AD  - Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Aldrighetti, Luca
AU  - Aldrighetti L
AD  - Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Ratti, Francesca
AU  - Ratti F
AD  - Hepatobiliary Surgery Division, IRCCS San Raffaele Hospital, Milan, Italy.
FAU - Wu, Andrew G R
AU  - Wu AGR
AD  - Yong Loo Lin School of Medicine, National University of Singapore, Singapore, 
      Singapore.
FAU - Kabir, Tousif
AU  - Kabir T
AD  - Department of General Surgery, Sengkang General Hospital, Singapore, Singapore.
FAU - Scatton, Olivier
AU  - Scatton O
AD  - Department of Digestive, HBP, and Liver Transplantation, Hopital 
      Pitie-Salpetriere, Sorbonne Universite, Paris, France.
FAU - Lim, Chetana
AU  - Lim C
AD  - Department of Digestive, HBP, and Liver Transplantation, Hopital 
      Pitie-Salpetriere, Sorbonne Universite, Paris, France.
FAU - Zhang, Wanguang
AU  - Zhang W
AD  - Hepatic Surgery Center and Hubei Key Laboratory of Hepato-Biliary-Pancreatic 
      Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, China.
FAU - Sijberden, Jasper
AU  - Sijberden J
AD  - Department of Surgery, Fondazione Poliambulanza, Brescia, Italy.
FAU - Aghayan, Davit L
AU  - Aghayan DL
AD  - The Intervention Centre and Department of HPB Surgery, Oslo University Hospital, 
      Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
FAU - Siow, Tiing-Foong
AU  - Siow TF
AD  - Division of General Surgery, Department of Surgery, Far Eastern Memorial 
      Hospital, New Taipei City, Taiwan.
FAU - Dokmak, Safi
AU  - Dokmak S
AD  - Department of HPB Surgery and Liver Transplantation, Beaujon Hospital, University 
      Paris Cite, Clichy, France.
FAU - Coelho, Fabricio Ferreira
AU  - Coelho FF
AD  - Liver Surgery Unit, Department of Gastroenterology, University of Sao Paulo 
      School of Medicine, Sao Paulo, Brazil.
FAU - Herman, Paulo
AU  - Herman P
AD  - Liver Surgery Unit, Department of Gastroenterology, University of Sao Paulo 
      School of Medicine, Sao Paulo, Brazil.
FAU - Marino, Marco V
AU  - Marino MV
AD  - General Surgery Department, Azienda Ospedaliera Ospedali Riuniti Villa 
      Sofia-Cervello, Palermo, Italy.
AD  - General Surgery Department, F. Tappeiner Hospital, Merano, Italy.
FAU - Mazzaferro, Vincenzo
AU  - Mazzaferro V
AD  - HPB Surgery and Liver Transplantation, Fondazione IRCCS Istituto Nazionale Tumori 
      di Milano and University of Milan, Milan, Italy.
FAU - Chiow, Adrian K H
AU  - Chiow AKH
AD  - Hepatopancreatobiliary Unit, Department of Surgery, Changi General Hospital, 
      Singapore, Singapore.
FAU - Sucandy, Iswanto
AU  - Sucandy I
AD  - Digestive Health Institute, AdventHealth Tampa, Tampa, Florida, USA.
FAU - Ivanecz, Arpad
AU  - Ivanecz A
AD  - Department of Abdominal and General Surgery, University Medical Center Maribor, 
      Maribor, Slovenia.
FAU - Choi, Sung-Hoon
AU  - Choi SH
AD  - Department of General Surgery, CHA Bundang Medical Center, CHA University School 
      of Medicine, Seongnam, Korea.
FAU - Lee, Jae Hoon
AU  - Lee JH
AD  - Division of Hepato-Biliary and Pancreatic Surgery, Department of Surgery, Asan 
      Medical Center, University of Ulsan College of Medicine, Seoul, Korea.
FAU - Gastaca, Mikel
AU  - Gastaca M
AD  - Hepatobiliary Surgery and Liver Transplantation Unit, Biocruces Bizkaia Health 
      Research Institute, Cruces University Hospital, University of the Basque Country, 
      Bilbao, Spain.
FAU - Vivarelli, Marco
AU  - Vivarelli M
AD  - HPB Surgery and Transplantation Unit, United Hospital of Ancona, Department of 
      Experimental and Clinical Medicine Polytechnic, University of Marche, Ancona, 
      Italy.
FAU - Giuliante, Felice
AU  - Giuliante F
AD  - Hepatobiliary Surgery Unit, Fondazione Policlinico Universitario A. Gemelli, 
      IRCCS, Catholic University of the Sacred Heart, Rome, Italy.
FAU - Ruzzenente, Andrea
AU  - Ruzzenente A
AD  - General and Hepatobiliary Surgery, Department of Surgery, Dentistry, Gynecology, 
      and Pediatrics, University of Verona, GB Rossi Hospital, Verona, Italy.
FAU - Yong, Chee-Chien
AU  - Yong CC
AD  - Department of Surgery, Chang Gung Memorial Hospital, Kaohsiung, Taiwan.
FAU - Yin, Mengqiu
AU  - Yin M
AD  - Department of Hepatobiliary Surgery, Affiliated Jinhua Hospital, Zhejiang 
      University School of Medicine, Jinhua, China.
FAU - Fondevila, Constantino
AU  - Fondevila C
AD  - General and Digestive Surgery, Hospital Clinic, IDIBAPS, CIBERehd, University of 
      Barcelona, Barcelona, Spain.
AD  - General and Digestive Surgery, Hospital Universitario La Paz, IdiPAZ, CIBERehd, 
      Madrid, Spain.
FAU - Efanov, Mikhail
AU  - Efanov M
AD  - Department of Hepato-Pancreato-Biliary Surgery, Moscow Clinical Scientific 
      Center, Moscow, Russia.
FAU - Morise, Zenichi
AU  - Morise Z
AD  - Department of Surgery, Okazaki Medical Center, Fujita Health University School of 
      Medicine, Okazaki, Japan.
FAU - Di Benedetto, Fabrizio
AU  - Di Benedetto F
AD  - HPB Surgery and Liver Transplant Unit, University of Modena and Reggio Emilia, 
      Modena, Italy.
FAU - Brustia, Raffaele
AU  - Brustia R
AD  - Department of Digestive and Hepatobiliary and Pancreatic Surgery, AP-HP, 
      Henri-Mondor Hospital, Creteil, France.
FAU - Dalla Valle, Raffaele
AU  - Dalla Valle R
AD  - Hepatobiliary Surgery Unit, Department of Medicine and Surgery, University of 
      Parma, Parma, Italy.
FAU - Boggi, Ugo
AU  - Boggi U
AD  - Division of General and Transplant Surgery, University of Pisa, Pisa, Italy.
FAU - Geller, David
AU  - Geller D
AD  - Division of Hepatobiliary and Pancreatic Surgery, Department of Surgery, 
      University of Pittsburgh Medical Center, Pittsburgh, PA, USA.
FAU - Belli, Andrea
AU  - Belli A
AD  - Division of Hepatopancreatobiliary Surgical Oncology, Department of Abdominal 
      Oncology, National Cancer Center - IRCCS-G. Pascale, Naples, Italy.
FAU - Memeo, Riccardo
AU  - Memeo R
AD  - Unit of Hepato-Pancreatc-Biliary Surgery, "F. Miulli" General Regional Hospital, 
      Acquaviva delle Fonti, Bari, Italy.
FAU - Gruttadauria, Salvatore
AU  - Gruttadauria S
AD  - Department for the Treatment and Study of Abdominal Diseases and Abdominal 
      Transplantation, Istituto di Ricovero e Cura a Carattere Scientifico-Istituto 
      Mediterraneo per i Trapianti e Terapie ad Alta Specializzazione (IRCCS-ISMETT), 
      University of Pittsburgh Medical Center Italy, Palermo, Italy.
AD  - Department of General Surgery and Medical Surgical Specialties, University of 
      Catania, Catania, Italy.
FAU - Mejia, Alejandro
AU  - Mejia A
AD  - The Liver Institute, Methodist Dallas Medical Center, Dallas, Texas, USA.
FAU - Park, James O
AU  - Park JO
AD  - Department of Surgery, University of Washington Medical Center, Seattle, WA, USA.
FAU - Rotellar, Fernando
AU  - Rotellar F
AD  - HPB and Liver Transplant Unit, Department of General Surgery, Clinica Universidad 
      de Navarra, Universidad de Navarra, Pamplona, Spain.
AD  - Institute of Health Research of Navarra (IdisNA), Pamplona, Spain.
FAU - Choi, Gi-Hong
AU  - Choi GH
AD  - Division of Hepatopancreatobiliary Surgery, Department of Surgery, Severance 
      Hospital, Yonsei University College of Medicine, Seoul, Korea.
FAU - Robles-Campos, Ricardo
AU  - Robles-Campos R
AD  - Department of General, Visceral and Transplantation Surgery, Clinic and 
      University Hospital Virgen de la Arrixaca, IMIB-ARRIXACA, El Palmar, Murcia, 
      Spain.
FAU - Wang, Xiaoying
AU  - Wang X
AD  - Department of Liver Surgery and Transplantation, Liver Cancer Institute, 
      Zhongshan Hospital, Fudan University, Shanghai, China.
FAU - Sutcliffe, Robert P
AU  - Sutcliffe RP
AD  - Department of Hepatopancreatobiliary and Liver Transplant Surgery, University 
      Hospitals Birmingham NHS Foundation Trust, Birmingham, UK.
FAU - Pratschke, Johann
AU  - Pratschke J
AD  - Department of Surgery, Campus Charite Mitte and Campus Virchow-Klinikum, 
      Charite-Universitatsmedizin, Corporate Member of Freie Universitat Berlin, and 
      Berlin Institute of Health, Berlin, Germany.
FAU - Lai, Eric C H
AU  - Lai ECH
AD  - Department of Surgery, Pamela Youde Nethersole Eastern Hospital, Hong Kong SAR, 
      China.
FAU - Chong, Charing C N
AU  - Chong CCN
AD  - Department of Surgery, Prince of Wales Hospital, The Chinese University of Hong 
      Kong, New Territories, Hong Kong SAR, China.
FAU - D'Hondt, Mathieu
AU  - D'Hondt M
AD  - Department of Digestive and Hepatobiliary/Pancreatic Surgery, Groeninge Hospital, 
      Kortrijk, Belgium.
FAU - Monden, Kazuteru
AU  - Monden K
AD  - Department of Surgery, Fukuyama City Hospital, Hiroshima, Japan.
FAU - Lopez-Ben, Santiago
AU  - Lopez-Ben S
AD  - Hepatobiliary and Pancreatic Surgery Unit, Department of Surgery, Dr. Josep 
      Trueta Hospital, IdIBGi, Girona, Spain.
FAU - Kingham, T Peter
AU  - Kingham TP
AD  - Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA.
FAU - Ferrero, Alessandro
AU  - Ferrero A
AD  - Department of General and Oncological Surgery, Mauriziano Hospital, Turin, Italy.
FAU - Ettorre, Giuseppe Maria
AU  - Ettorre GM
AD  - Division of General Surgery and Liver Transplantation, S. Camillo Forlanini 
      Hospital, Rome, Italy.
FAU - Cherqui, Daniel
AU  - Cherqui D
AD  - Department of Hepatobiliary Surgery, Assistance Publique Hopitaux de Paris, 
      Centre Hepato-Biliaire, Paul-Brousse Hospital, Villejuif, France.
FAU - Liang, Xiao
AU  - Liang X
AD  - Department of General Surgery, Sir Run-Run Shaw Hospital, Zhejiang University 
      School of Medicine, Hangzhou, China.
FAU - Soubrane, Olivier
AU  - Soubrane O
AD  - Department of Digestive, Oncologic and Metabolic Surgery, Institute Mutualiste 
      Montsouris, Universite Paris Descartes, Paris, France.
FAU - Wakabayashi, Go
AU  - Wakabayashi G
AD  - Center for Advanced Treatment of Hepatobiliary and Pancreatic Diseases, Ageo 
      Central General Hospital, Saitama, Japan.
FAU - Troisi, Roberto I
AU  - Troisi RI
AD  - Department of Clinical Medicine and Surgery, Division of HPB, Minimally Invasive 
      and Robotic Surgery, Federico II University Hospital Naples, Naples, Italy.
FAU - Cheung, Tan-To
AU  - Cheung TT
AD  - Department of Surgery, Queen Mary Hospital, The University of Hong Kong, Hong 
      Kong SAR, China.
FAU - Kato, Yutaro
AU  - Kato Y
AD  - Department of Surgery, Fujita Health University School of Medicine, Aichi, Japan.
FAU - Sugioka, Atsushi
AU  - Sugioka A
AD  - Department of Surgery, Fujita Health University School of Medicine, Aichi, Japan.
FAU - Han, Ho-Seong
AU  - Han HS
AD  - Department of Surgery, Seoul National University Hospital Bundang, Seoul National 
      University College of Medicine, Seoul, Korea.
FAU - Long, Tran Cong Duy
AU  - Long TCD
AD  - Department of Hepatopancreatobiliary Surgery, University Medical Center, 
      University of Medicine and Pharmacy, Ho Chi Minh City, Vietnam.
FAU - Liu, Qu
AU  - Liu Q
AD  - Faculty of Hepatopancreatobiliary Surgery, The First Medical Center of Chinese 
      People's Liberation Army (PLA) General Hospital, Beijing, China.
FAU - Liu, Rong
AU  - Liu R
AD  - Faculty of Hepatopancreatobiliary Surgery, The First Medical Center of Chinese 
      People's Liberation Army (PLA) General Hospital, Beijing, China.
FAU - Edwin, Bjorn
AU  - Edwin B
AD  - The Intervention Centre and Department of HPB Surgery, Oslo University Hospital, 
      Institute of Clinical Medicine, University of Oslo, Oslo, Norway.
FAU - Fuks, David
AU  - Fuks D
AD  - Department of Digestive, Oncologic and Metabolic Surgery, Institute Mutualiste 
      Montsouris, Universite Paris Descartes, Paris, France.
FAU - Chen, Kuo-Hsin
AU  - Chen KH
AD  - Division of General Surgery, Department of Surgery, Far Eastern Memorial 
      Hospital, New Taipei City, Taiwan.
FAU - Abu Hilal, Mohammad
AU  - Abu Hilal M
AD  - Department of Surgery, Fondazione Poliambulanza, Brescia, Italy.
AD  - Department of Surgery, University Hospital Southampton, Southampton, UK.
FAU - Goh, Brian K P
AU  - Goh BKP
AUID- ORCID: 0000-0001-8218-4576
AD  - Department of Hepatopancreatobiliary and Transplant Surgery, Singapore General 
      Hospital and National Cancer Centre Singapore, Singapore, Singapore. 
      bsgkp@hotmail.com.
AD  - Surgery Academic Clinical Programme, Duke National University of Singapore 
      Medical School, Singapore, Singapore. bsgkp@hotmail.com.
CN  - International Robotic and Laparoscopic Liver Resection Study Group Investigators
LA  - eng
GR  - P30 CA008747/National Cancer Institute MSKCC core grant/
GR  - LGF20H160028/zhejiang provincial public welfare fund/
PT  - Journal Article
DEP - 20231107
PL  - United States
TA  - Ann Surg Oncol
JT  - Annals of surgical oncology
JID - 9420840
SB  - IM
MH  - Humans
MH  - *Liver Neoplasms/complications/surgery
MH  - *Robotic Surgical Procedures
MH  - Hepatectomy/methods
MH  - Retrospective Studies
MH  - Postoperative Complications/etiology/surgery
MH  - Liver Cirrhosis/complications/surgery/pathology
MH  - *Laparoscopy/methods
MH  - *Hypertension, Portal/etiology/surgery
MH  - Length of Stay
MH  - Propensity Score
OTO - NOTNLM
OT  - Cirrhosis
OT  - Difficulty score
OT  - Laparoscopic hepatectomy
OT  - Laparoscopic liver
OT  - Minimally invasive hepatectomy
OT  - Minimally invasive liver
FIR - Syn, Nicholas L
IR  - Syn NL
FIR - Prieto, Mikel
IR  - Prieto M
FIR - De Meyere, Celine
IR  - De Meyere C
FIR - Meurs, Juul
IR  - Meurs J
FIR - Ng, Kelvin K
IR  - Ng KK
FIR - Lee, Kit-Fai
IR  - Lee KF
FIR - Salimgereeva, Diana
IR  - Salimgereeva D
FIR - Alikhanov, Ruslan
IR  - Alikhanov R
FIR - Thiruchelvam, Nita
IR  - Thiruchelvam N
FIR - Jang, Jae Young
IR  - Jang JY
FIR - Kojima, Masayuki
IR  - Kojima M
FIR - Kruger, Jaime Arthur Pirola
IR  - Kruger JAP
FIR - Lopez-Lopez, Victor
IR  - Lopez-Lopez V
FIR - Robert, Margarida Casellas I
IR  - Robert MCI
FIR - Montalti, Roberto
IR  - Montalti R
FIR - Giglio, Mariano
IR  - Giglio M
FIR - Lee, Boram
IR  - Lee B
FIR - D'Silva, Mizelle
IR  - D'Silva M
FIR - Wang, Hao-Ping
IR  - Wang HP
FIR - Pascual, Franco
IR  - Pascual F
FIR - Saleh, Mansour
IR  - Saleh M
FIR - Yu, Shian
IR  - Yu S
FIR - Chen, Zewei
IR  - Chen Z
FIR - Vani, Simone
IR  - Vani S
FIR - Ardito, Francesco
IR  - Ardito F
FIR - Giustizieri, Ugo
IR  - Giustizieri U
FIR - Citterio, Davide
IR  - Citterio D
FIR - Mocchegiani, Federico
IR  - Mocchegiani F
FIR - Colasanti, Marco
IR  - Colasanti M
FIR - Berardi, Giammauro
IR  - Berardi G
FIR - Guzman, Yoelimar
IR  - Guzman Y
FIR - Labadie, Kevin P
IR  - Labadie KP
FIR - Conticchio, Maria
IR  - Conticchio M
FIR - Dogeas, Epameinondas
IR  - Dogeas E
FIR - Kauffmann, Emanuele F
IR  - Kauffmann EF
FIR - Giuffrida, Mario
IR  - Giuffrida M
FIR - Sommacale, Daniele
IR  - Sommacale D
FIR - Laurent, Alexis
IR  - Laurent A
FIR - Magistri, Paolo
IR  - Magistri P
FIR - Mishima, Kohei
IR  - Mishima K
FIR - Schmelzle, Moritz
IR  - Schmelzle M
FIR - Krenzien, Felix
IR  - Krenzien F
FIR - Kadam, Prashant
IR  - Kadam P
FIR - Tang, Chung-Ngai
IR  - Tang CN
FIR - Ghotbi, Jacob
IR  - Ghotbi J
FIR - Fretland, Asmund Avdem
IR  - Fretland AA
FIR - Forchino, Fabio
IR  - Forchino F
FIR - Dalla Valle, Bernardo
IR  - Dalla Valle B
FIR - Zheng, Junhao
IR  - Zheng J
FIR - Mazzotta, Alessandro
IR  - Mazzotta A
FIR - Nghia, Phan Phuoc
IR  - Nghia PP
FIR - Cauchy, Francois
IR  - Cauchy F
EDAT- 2023/11/08 00:42
MHDA- 2023/12/07 12:42
CRDT- 2023/11/07 23:52
PHST- 2023/07/14 00:00 [received]
PHST- 2023/09/17 00:00 [accepted]
PHST- 2023/12/07 12:42 [medline]
PHST- 2023/11/08 00:42 [pubmed]
PHST- 2023/11/07 23:52 [entrez]
AID - 10.1245/s10434-023-14376-5 [pii]
AID - 10.1245/s10434-023-14376-5 [doi]
PST - ppublish
SO  - Ann Surg Oncol. 2024 Jan;31(1):97-114. doi: 10.1245/s10434-023-14376-5. Epub 2023 
      Nov 7.