PMID- 37936585
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231109
IS  - 2327-2120 (Electronic)
IS  - 2327-2120 (Linking)
VI  - 10
DP  - 2023
TI  - The diagnostic value of fluorescence in situ hybridization in secondary 
      electroresection of bladder cancer.
PG  - e21200006
LID - 10.14440/bladder.2023.861 [doi]
LID - e21200006
AB  - OBJECTIVE: To investigate the utility of fluorescence in situ hybridization 
      (FISH) in secondary electroresection of bladder cancer. METHODS: From January 
      2016 to April 2022, bladder cancer patients who had undergone secondary 
      electroresection in Tongji Hospital and had preoperative urine FISH were 
      recruited, and the positive rate, accuracy, sensitivity, specificity, genetic 
      material changes and predictive power on malignancy degree of FISH in the 
      secondary electroresection of bladder cancer were examined. RESULTS: Twenty-six 
      patients with bladder cancer were included in this study, and 8 were confirmed by 
      secondary electroresection, including 6 cases positive for FISH positive and 2 
      negative for FISH. Besides, among the subjects, 18 were without tumor recurrence, 
      including 1 case with positive FISH results and 17 with negative FISH results. 
      Tumor recurrence was diagnosed in 85.71% (6/7) of FISH-positive patients in 
      secondary electroresection while only 10.53% (2/19) of FISH-negative patients 
      were found to develop tumor recurrence in the secondary electroresection. The 
      sensitivity of FISH for the detection of bladder cancer before secondary 
      electroresection was 75%, with a specificity of 94.44%, and an accuracy of 
      88.46%. A 6-month follow-up revealed that 2 of the 8 recurrent patients underwent 
      radical resection of bladder cancer, and the remaining 6 patients had no 
      recurrence, as confirmed by regular bladder perfusion and microscopy. In the 18 
      non-recurrent patients during secondary electroresection, no recurrence 
      developed. CONCLUSIONS: Urine FISH can achieve a high detection rate and 
      specificity for secondary electroresection of bladder cancer. If a bladder cancer 
      patient who are indicated for secondary electroresection is negative for urine 
      FISH, the recurrence rate after secondary electroresection will be low, and the 
      cystoscopy can be performed before deciding whether to perform secondary 
      electroresection.
CI  - (c) 2013-2023 Bladder, All rights reserved.
FAU - Chen, Bowen
AU  - Chen B
AD  - Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Shu, Bo
AU  - Shu B
AD  - Department of Urology, The Central Hospital of Wuhan, Tongji Medical College, 
      Huazhong University of Science and Technology, Wuhan, Hubei, China.
FAU - Liu, Zhenghao
AU  - Liu Z
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430014, China.
FAU - Zhu, Junyu
AU  - Zhu J
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430014, China.
FAU - Ke, Chunjin
AU  - Ke C
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430014, China.
FAU - Zeng, Xing
AU  - Zeng X
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430014, China.
FAU - Hu, Zhiquan
AU  - Hu Z
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430014, China.
FAU - Yang, Chunguang
AU  - Yang C
AD  - Department of Urology, Tongji Hospital, Tongji Medical College, Huazhong 
      University of Science and Technology, Wuhan 430014, China.
LA  - eng
PT  - Journal Article
DEP - 20230725
PL  - United States
TA  - Bladder (San Franc)
JT  - Bladder (San Francisco, Calif.)
JID - 101664418
PMC - PMC10627079
OTO - NOTNLM
OT  - Bladder cancer
OT  - diagnosis
OT  - fluorescence in situ hybridization technique
OT  - secondary electrocution
EDAT- 2023/11/08 06:44
MHDA- 2023/11/08 06:45
PMCR- 2023/07/25
CRDT- 2023/11/08 03:49
PHST- 2023/01/19 00:00 [received]
PHST- 2023/03/29 00:00 [revised]
PHST- 2023/03/31 00:00 [accepted]
PHST- 2023/11/08 06:45 [medline]
PHST- 2023/11/08 06:44 [pubmed]
PHST- 2023/11/08 03:49 [entrez]
PHST- 2023/07/25 00:00 [pmc-release]
AID - 10.14440/bladder.2023.861 [doi]
PST - epublish
SO  - Bladder (San Franc). 2023 Jul 25;10:e21200006. doi: 10.14440/bladder.2023.861. 
      eCollection 2023.