PMID- 37939447
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231113
IS  - 1618-0631 (Electronic)
IS  - 0344-0338 (Linking)
VI  - 251
DP  - 2023 Nov
TI  - Voltage-gated sodium channels in cancer and their specific inhibitors.
PG  - 154909
LID - S0344-0338(23)00610-6 [pii]
LID - 10.1016/j.prp.2023.154909 [doi]
AB  - Voltage-gated sodium channels (VGSCs) participate in generating and spreading 
      action potentials in electrically excited cells such as neurons and muscle 
      fibers. Abnormal expression of VGSCs has been observed in various types of 
      tumors, while they are either not expressed or expressed at a low level in the 
      matching normal tissue. Hence, this abnormal expression suggests that VGSCs 
      confer some advantage or viability on tumor cells, making them a valuable 
      indicator for identifying tumor cells. In addition, overexpression of VGSCs 
      increased the ability of cancer cells to metastasize and invade, as well as 
      correlated with the metastatic behavior of different cancers. Therefore, blocking 
      VGSCs presents a new strategy for the treatment of cancers. A portion of this 
      review summarizes the structure and function of VGSCs and also describes the 
      correlation between VGSCs and cancers. Most importantly, we provide an overview 
      of current research on various subtype-selective VGSC inhibitors and updates on 
      ongoing clinical studies.
CI  - Copyright (c) 2023. Published by Elsevier GmbH.
FAU - Bian, Yuan
AU  - Bian Y
AD  - School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, 
      Shenyang, Liaoning 110016, PR China.
FAU - Tuo, Jiale
AU  - Tuo J
AD  - School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, 
      Shenyang, Liaoning 110016, PR China.
FAU - He, Liangpeng
AU  - He L
AD  - School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, 
      Shenyang, Liaoning 110016, PR China.
FAU - Li, Wenwen
AU  - Li W
AD  - School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, 
      Shenyang, Liaoning 110016, PR China.
FAU - Li, Shangxiao
AU  - Li S
AD  - School of Medical Devices, Shenyang Pharmaceutical University, Benxi, Liaoning 
      117004, PR China.
FAU - Chu, Huiying
AU  - Chu H
AD  - Laboratory of Molecular Modeling and Design, State Key Laboratory of Molecular 
      Reaction Dynamics, Dalian Institute of Chemical Physics, Chinese Academy of 
      Sciences, Dalian, China.
FAU - Zhao, Yongshan
AU  - Zhao Y
AD  - School of Life Science and Bio-Pharmaceutics, Shenyang Pharmaceutical University, 
      Shenyang, Liaoning 110016, PR China. Electronic address: zhaoys@syphu.edu.cn.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231028
PL  - Germany
TA  - Pathol Res Pract
JT  - Pathology, research and practice
JID - 7806109
RN  - 0 (Voltage-Gated Sodium Channels)
SB  - IM
MH  - Humans
MH  - *Voltage-Gated Sodium Channels/metabolism
MH  - *Neoplasms/drug therapy/metabolism
MH  - Neurons/metabolism
OTO - NOTNLM
OT  - Cancer
OT  - Inhibitors
OT  - Therapeutic target
OT  - Voltage-gated sodium channels
COIS- Declaration of Competing Interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/09 00:42
MHDA- 2023/11/13 06:43
CRDT- 2023/11/08 18:02
PHST- 2023/02/19 00:00 [received]
PHST- 2023/10/23 00:00 [revised]
PHST- 2023/10/24 00:00 [accepted]
PHST- 2023/11/13 06:43 [medline]
PHST- 2023/11/09 00:42 [pubmed]
PHST- 2023/11/08 18:02 [entrez]
AID - S0344-0338(23)00610-6 [pii]
AID - 10.1016/j.prp.2023.154909 [doi]
PST - ppublish
SO  - Pathol Res Pract. 2023 Nov;251:154909. doi: 10.1016/j.prp.2023.154909. Epub 2023 
      Oct 28.