PMID- 37939696
OWN - NLM
STAT- MEDLINE
DCOM- 20240205
LR  - 20240206
IS  - 1421-9875 (Electronic)
IS  - 0257-2753 (Linking)
VI  - 42
IP  - 1
DP  - 2024
TI  - Proton Pump Inhibitor Use and Iron Deficiency Anemia in Celiac Patients.
PG  - 25-30
LID - 10.1159/000534800 [doi]
AB  - INTRODUCTION: We sought to evaluate the effect of proton pump inhibitor (PPI) use 
      on the development and severity of iron deficiency anemia (IDA) in celiac disease 
      (CD). METHODS: We conducted a retrospective chart review of patients older than 
      18 years of age at Milton S. Hershey Medical Center who were diagnosed with CD. 
      We analyzed four cohorts of celiac patients: (1) IDA diagnosis with PPI usage, 
      (2) no IDA diagnosis with PPI usage, (3) IDA diagnosis with no PPI usage, and (4) 
      no IDA diagnosis with no PPI usage. We also stratified celiac patients with IDA 
      by anemia severity. RESULTS: Of 366 celiac patients, 92 (25.1%) were diagnosed 
      with IDA, of which 60 (65.2%) were on a PPI. The mean Hgb of celiac patients with 
      IDA on a PPI was 11.1 g/dL and 12.1 g/dL for those without PPI (p = 0.04). For 
      all celiac patients on a PPI without IDA, the mean was 13.3 g/dL and 13.7 g/dL 
      for those without PPI (p = 0.02). PPI use occurred in 12 (70.6%) of the 17 
      patients with low severity anemia, 11 (64.7%) of the 17 patients with medium 
      severity and 6 (85.7%) of the 7 patients with severe (p = 0.55). CONCLUSIONS: 
      There is significant association between PPI use and IDA in celiac patients (p 
      < 0.0001). Of those with IDA on PPIs, the distribution of the severity of 
      anemia is not statistically different compared to those not on PPI. 
      Discontinuation of PPIs or usage of alternative acid suppressive treatments may 
      be indicated in patients with CD and iron deficiency anemia.
CI  - (c) 2023 S. Karger AG, Basel.
FAU - Hawkins, Stephanie
AU  - Hawkins S
AD  - Penn State College of Medicine, Hershey, Pennsylvania, USA.
FAU - Nighot, Meghali
AU  - Nighot M
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Penn State 
      College of Medicine, Hershey, Pennsylvania, USA.
FAU - Dalessio, Shannon
AU  - Dalessio S
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Penn State 
      College of Medicine, Hershey, Pennsylvania, USA, 
      sdalessio@pennstatehealth.psu.edu.
FAU - Zhu, Junjia
AU  - Zhu J
AD  - Division of Biostatistics and Bioinformatics, Department of Public Health 
      Sciences, Penn State College of Medicine, Hershey, Pennsylvania, USA.
FAU - Morris, Nathan
AU  - Morris N
AD  - Penn State College of Medicine, Hershey, Pennsylvania, USA.
FAU - Clarke, Kofi
AU  - Clarke K
AD  - Division of Gastroenterology and Hepatology, Department of Medicine, Penn State 
      College of Medicine, Hershey, Pennsylvania, USA.
LA  - eng
PT  - Journal Article
DEP - 20231108
PL  - Switzerland
TA  - Dig Dis
JT  - Digestive diseases (Basel, Switzerland)
JID - 8701186
RN  - 0 (Proton Pump Inhibitors)
SB  - IM
MH  - Humans
MH  - *Anemia, Iron-Deficiency/drug therapy/epidemiology/etiology
MH  - Proton Pump Inhibitors/adverse effects
MH  - Retrospective Studies
MH  - *Celiac Disease/complications/diagnosis
OTO - NOTNLM
OT  - Celiac disease
OT  - Iron deficiency anemia
OT  - Proton pump inhibitors
EDAT- 2023/11/09 00:42
MHDA- 2024/02/05 06:44
CRDT- 2023/11/08 18:27
PHST- 2023/05/19 00:00 [received]
PHST- 2023/10/18 00:00 [accepted]
PHST- 2024/02/05 06:44 [medline]
PHST- 2023/11/09 00:42 [pubmed]
PHST- 2023/11/08 18:27 [entrez]
AID - 000534800 [pii]
AID - 10.1159/000534800 [doi]
PST - ppublish
SO  - Dig Dis. 2024;42(1):25-30. doi: 10.1159/000534800. Epub 2023 Nov 8.