PMID- 37939783
OWN - NLM
STAT- Publisher
LR  - 20240404
IS  - 1369-1619 (Electronic)
IS  - 0960-3123 (Linking)
DP  - 2023 Nov 8
TI  - Long-term exposure to PM(2.5) compositions and O(3) and their interactive effects 
      on DNA methylation of peripheral brain-derived neurotrophic factor promoter.
PG  - 1-12
LID - 10.1080/09603123.2023.2280157 [doi]
AB  - This study examined the associations of long-term exposure to ambient fine 
      particulate matter (PM(2.5)) compositions/ozone with methylation of peripheral 
      brain-derived neurotrophic factor (BDNF) promoters. A total of 101 participants 
      were recruited from a cohort in Shijiazhuang, Hebei province, China. They 
      underwent baseline and follow-up surveys in 2011 and 2015. DNA methylation levels 
      were detected by bisulfite-PCR amplification and pyrosequencing. Participants' 
      three-year average levels of PM(2.5) compositions and ozone were estimated. 
      Bayesian kernel machine regression (BKMR) models were used to examine the joint 
      effects of pollutants on methylation levels. Exposure to PM(2.5) compositions and 
      ozone mixtures at the 75th percentile was associated with increased methylation 
      levels at CpG2 of BDNF promoter (203%, 95% CI: 89, 316) than the lowest level of 
      exposure, and sulfate dominated the effect in the BKMR models.Our findings 
      provide clues to the epigenetic mechanisms for the associations of PM(2.5) 
      compositions and ozone with BDNF.
FAU - Huang, Haoyu
AU  - Huang H
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Xie, Bing
AU  - Xie B
AD  - College of Forensic Medicine, Hebei Medical University, Shijiazhuang, China.
AD  - Hebei Key Laboratory of Forensic Medicine, Collaborative Innovation Center of 
      Forensic Medical Molecular Identification, Research Unit of Digestive Tract 
      Microecosystem Pharmacology and Toxicology, Chinese Academy of Medical Sciences, 
      Shijiazhuang, China.
FAU - Liu, Yuewei
AU  - Liu Y
AD  - Department of Epidemiology, School of Public Health, Sun Yat-sen University, 
      Guangzhou, China.
FAU - Dong, Guang-Hui
AU  - Dong GH
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Liu, Ruqing
AU  - Liu R
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Gui, Zhaohuan
AU  - Gui Z
AD  - Department of Occupational and Environmental Health, School of Public Health, Sun 
      Yat-sen University, Guangzhou, China.
FAU - Chen, Lijun
AU  - Chen L
AD  - College of Information Engineering, Hubei University of Chinese Medicine, Wuhan, 
      China.
FAU - Li, Shanshan
AU  - Li S
AD  - Climate, Air Quality Research Unit, School of Public Health and Preventive 
      Medicine, Monash University, Melbourne, Australia.
FAU - Guo, Yuming
AU  - Guo Y
AD  - Climate, Air Quality Research Unit, School of Public Health and Preventive 
      Medicine, Monash University, Melbourne, Australia.
FAU - Yang, Lei
AU  - Yang L
AD  - Department of Epidemiology and Biostatistics, School of Public Health, Hebei Key 
      Laboratory of Environment and Human Health, Hebei Medical University, 
      Shijiazhuang, China.
FAU - Chen, Gongbo
AU  - Chen G
AD  - Climate, Air Quality Research Unit, School of Public Health and Preventive 
      Medicine, Monash University, Melbourne, Australia.
LA  - eng
PT  - Journal Article
DEP - 20231108
PL  - England
TA  - Int J Environ Health Res
JT  - International journal of environmental health research
JID - 9106628
SB  - IM
OTO - NOTNLM
OT  - BDNF promoter
OT  - DNA methylation
OT  - Particulate matter
OT  - ozone
OT  - sulfate
EDAT- 2023/11/09 00:42
MHDA- 2023/11/09 00:42
CRDT- 2023/11/08 19:13
PHST- 2023/11/09 00:42 [pubmed]
PHST- 2023/11/09 00:42 [medline]
PHST- 2023/11/08 19:13 [entrez]
AID - 10.1080/09603123.2023.2280157 [doi]
PST - aheadofprint
SO  - Int J Environ Health Res. 2023 Nov 8:1-12. doi: 10.1080/09603123.2023.2280157.