PMID- 37941733
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231110
IS  - 2364-3722 (Print)
IS  - 2196-9736 (Electronic)
IS  - 2196-9736 (Linking)
VI  - 11
IP  - 8
DP  - 2023 Aug
TI  - Settings of a novel electrosurgical generator to enable efficient and safe 
      submucosal endoscopic procedures.
PG  - E743-E751
LID - 10.1055/a-2085-3757 [doi]
AB  - Background and study aims A novel electrosurgical generator unit (ESU), ConMed 
      Beamer, was recently introduced to facilitate endoscopic submucosal dissection 
      (ESD) by employing Automatic Cutting Effect (ACE) technology. Its use in 
      submucosal endoscopy has yet to be investigated. The aim of this study was to 
      evaluate the feasibility and safety of performing ESD and peroral endoscopic 
      myotomy (POEM) using novel settings generated with ConMed Beamer ESU. Patients 
      and methods This was a single-center prospective study of 59 consecutive patients 
      undergoing ESD/POEM at a tertiary referral center. ESU settings were initially 
      generated by testing in live animal models prior to first in-human study. The 
      primary outcome was technical success. Secondary outcomes were procedure times, 
      rate of en bloc/R0 resection, and rate of adverse events (AEs). Results A total 
      of 44 patients (50 polyps) and 15 patients underwent ESD and POEM, respectively. 
      En bloc resection, R0 resection, and curative resection rates were 90%, 77.1%, 
      and 70.8%, respectively. Mean maximal length of the lesion was 3.07 cm +/- 1.43 
      with an average dissection speed of 14.2 cm (2) /hr +/- 11.1. Technical success was 
      achieved in 100% of POEM patients. Mean time (minutes) to complete the POEM 
      procedure was 50.1 min +/- 12.4. Two major AEs occurred among all patients (3.4%). 
      All intraprocedural bleeding events were controlled using the ConMed Beamer ESU. 
      Conclusions ConMed Beamer ESU settings generated from this study were proven safe 
      and effective in a prospective cohort of patients who underwent submucosal 
      endoscopic procedures. This novel ESU can be added to the armamentarium of ESD 
      capable generators.
CI  - The Author(s). This is an open access article published by Thieme under the terms 
      of the Creative Commons Attribution-NonDerivative-NonCommercial-License, 
      permitting copying and reproduction so long as the original work is given 
      appropriate credit. Contents may not be used for commercial purposes, or adapted, 
      remixed, transformed or built upon. 
      (https://creativecommons.org/licenses/by-nc-nd/4.0/).
FAU - Jawaid, Salmaan
AU  - Jawaid S
AD  - Gastroenterology, Baylor College of Medicine, Houston, United States. RINGGOLD: 
      3989
FAU - Keihanian, Tara
AU  - Keihanian T
AD  - Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, 
      United States. RINGGOLD: 3989
FAU - Khalaf, Mai
AU  - Khalaf M
AD  - Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, 
      United States. RINGGOLD: 3989
FAU - Riojas-Barrett, Margarita
AU  - Riojas-Barrett M
AD  - Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, 
      United States. RINGGOLD: 3989
FAU - Abdeljaber, Wesam
AU  - Abdeljaber W
AD  - Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, 
      United States. RINGGOLD: 3989
FAU - Mercado, Michael
AU  - Mercado M
AUID- ORCID: 0000-0002-6633-0235
AD  - Gastroenterology, Baylor College of Medicine, Houston, United States. RINGGOLD: 
      3989
FAU - Zabad, Noor
AU  - Zabad N
AUID- ORCID: 0000-0002-2102-0524
AD  - Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, 
      United States. RINGGOLD: 3989
FAU - Othman, Mohamed O
AU  - Othman MO
AUID- ORCID: 0000-0002-5888-4334
AD  - Division of Gastroenterology and Hepatology, Baylor College of Medicine, Houston, 
      United States. RINGGOLD: 3989
LA  - eng
PT  - Journal Article
DEP - 20230816
PL  - Germany
TA  - Endosc Int Open
JT  - Endoscopy international open
JID - 101639919
PMC - PMC10629488
COIS- Conflict of Interest Mohamed O. Othman: Mohamed O Othman is a consultant for 
      Olympus, Boston Scientific Corporation, Abbvie, ConMed, Creo Medical, Lumendi, 
      Nestle and Apollo. Mohamed O Othman received research grants from Lucid 
      Diagnostics, AbbVie, ConMed, Olympus and Boston Scientific. Salmaan Jawaid: 
      Salmaan Jawaid is a consultant for ConMed, Creo Medical, and Lumendi. Tara 
      Keihanian: Tara Keihanian is a consultant for Lumendi and Neptune medical. Mai 
      Khalaf, Margarita Riojas-Barrett, Wesam Abdeljaber, Michael Mercado & Noor Zabad 
      have no conflicts of interest. This study was investigator-initiated study funded 
      by ConMed. The funding body was not involved with the study design, execution or 
      results. The funding body did not contribute to the drafting of this manuscript.
EDAT- 2023/11/09 06:42
MHDA- 2023/11/09 06:43
PMCR- 2023/08/01
CRDT- 2023/11/09 04:11
PHST- 2023/01/23 00:00 [received]
PHST- 2023/04/18 00:00 [accepted]
PHST- 2023/11/09 06:43 [medline]
PHST- 2023/11/09 06:42 [pubmed]
PHST- 2023/11/09 04:11 [entrez]
PHST- 2023/08/01 00:00 [pmc-release]
AID - EIO-2023-01-2927-OA [pii]
AID - 10.1055/a-2085-3757 [doi]
PST - epublish
SO  - Endosc Int Open. 2023 Aug 16;11(8):E743-E751. doi: 10.1055/a-2085-3757. 
      eCollection 2023 Aug.