PMID- 37942754
OWN - NLM
STAT- MEDLINE
DCOM- 20240201
LR  - 20240201
IS  - 1473-5687 (Electronic)
IS  - 0954-691X (Linking)
VI  - 36
IP  - 1
DP  - 2024 Jan 1
TI  - Effect of exercise intervention on clinical parameters in patients with 
      non-alcoholic fatty liver disease and type 2 diabetes mellitus: a meta-analysis 
      of randomized controlled trials.
PG  - 1-12
LID - 10.1097/MEG.0000000000002662 [doi]
AB  - The effect of exercise on clinical parameters in patients with non-alcoholic 
      fatty liver disease (NAFLD) combined with type 2 diabetes mellitus (T2DM) is 
      unknown. In this meta-analysis, we identified and evaluated the effect of 
      exercise on clinical parameters (BMI, ALT, lipid metabolism, glucose metabolism) 
      in patients with NAFLD combined with T2DM. We conducted a comprehensive search of 
      Medline, Embase, Web of Science, Cochrane Database of Systematic Reviews, and 
      CNKI in December 2022. Data from relevant randomized controlled trials were 
      collected according to inclusion and exclusion criteria. 6 eligible studies with 
      238 subjects were finally included. We used Review Manager 5.3 for meta-analysis. 
      The study found that exercise improved BMI, ALT, TC, LDL-C, HbA1c, and HOMA-IR, 
      TG, but did not significantly improve HDL-C. Subgroup analysis showed that 
      high-intensity interval training significantly improved BMI (SMD: -0.43, 95% CI: 
      -0.80, -0.06), ALT (SMD: -4.63, 95% CI: -8.42, -0.83), TC (SMD: -0.94, 95% CI: 
      -1.82, -0.07), LDL-C (SMD: -0. 87, 95% CI: -1.26, -0.49), HbA1c (SMD: -1.12, 95% 
      CI: -1.75, -0.48), HOMA-IR (SMD: -0.59, 95% CI: -0.94, -0.25); moderate-intensity 
      continuous training improved ALT (SMD: -3.96, 95% CI: -7.71, -0.21), TG (SMD: 
      -1.59, 95% CI: -2.58, -0.61), HbA1c (SMD: -0.71, 95% CI: -1.37, -0.05), HOMA-IR 
      (SMD: -1.73, 95% CI: -3.40, -0. 06), and to some extent HDL-C levels (SMD: 0.53, 
      95% CI: 0.04, 1.02); resistance training improved LDL-C (SMD: -2.06, 95% CI: 
      -3.14, -0.98). In conclusion, exercise improved indicators in patients with NAFLD 
      combined with T2DM, but the improvement indicators varied by type of exercise.
CI  - Copyright (c) 2023 Wolters Kluwer Health, Inc. All rights reserved.
FAU - Zeng, Yu
AU  - Zeng Y
AD  - Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical 
      University.
FAU - Zhang, Xuemei
AU  - Zhang X
AD  - Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical 
      University.
FAU - Luo, Wenling
AU  - Luo W
AD  - Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical 
      University.
FAU - Sheng, Yunjian
AU  - Sheng Y
AD  - Department of Infectious Diseases, The Affiliated Hospital of Southwest Medical 
      University.
AD  - Infection & Immunity Laboratory, The Affiliated Hospital of Southwest Medical 
      University, Luzhou, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - England
TA  - Eur J Gastroenterol Hepatol
JT  - European journal of gastroenterology & hepatology
JID - 9000874
RN  - 0 (Cholesterol, LDL)
RN  - 0 (Glycated Hemoglobin)
SB  - IM
MH  - Humans
MH  - Cholesterol, LDL
MH  - *Diabetes Mellitus, Type 2/complications/diagnosis/therapy
MH  - Exercise Therapy
MH  - Glycated Hemoglobin
MH  - *Non-alcoholic Fatty Liver Disease/complications/diagnosis/therapy
MH  - Randomized Controlled Trials as Topic
EDAT- 2023/11/09 06:42
MHDA- 2023/12/07 12:42
CRDT- 2023/11/09 05:53
PHST- 2023/12/07 12:42 [medline]
PHST- 2023/11/09 06:42 [pubmed]
PHST- 2023/11/09 05:53 [entrez]
AID - 00042737-990000000-00257 [pii]
AID - 10.1097/MEG.0000000000002662 [doi]
PST - ppublish
SO  - Eur J Gastroenterol Hepatol. 2024 Jan 1;36(1):1-12. doi: 
      10.1097/MEG.0000000000002662.