PMID- 37942943
OWN - NLM
STAT- Publisher
LR  - 20231109
IS  - 1549-7852 (Electronic)
IS  - 1040-8398 (Linking)
DP  - 2023 Nov 9
TI  - Modulation of the replication of positive-sense RNA viruses by the natural plant 
      metabolite xanthohumol and its derivatives.
PG  - 1-15
LID - 10.1080/10408398.2023.2275169 [doi]
AB  - The COVID-19 pandemic has highlighted the importance of identifying new potent 
      antiviral agents. Nutrients as well as plant-derived substances are promising 
      candidates because they are usually well tolerated by the human body and readily 
      available in nature, and consequently mostly cheap to produce. A variety of 
      antiviral effects have recently been described for the hop chalcone xanthohumol 
      (XN), and to a lesser extent for its derivatives, making these hop compounds 
      particularly attractive for further investigation. Noteworthy, mounting evidence 
      indicated that XN can suppress a wide range of viruses belonging to several virus 
      families, all of which share a common reproductive cycle. As a result, the 
      purpose of this review is to summarize the most recent research on the antiviral 
      properties of XN and its derivatives, with a particular emphasis on the 
      positive-sense RNA viruses human hepatitis C virus (HCV), porcine reproductive 
      and respiratory syndrome virus (PRRSV), and severe acute respiratory syndrome 
      corona virus (SARS-CoV-2).
FAU - Marongiu, Luigi
AU  - Marongiu L
AD  - Department of Nutritional Biochemistry, University of Hohenheim, Stuttgart, 
      Germany.
AD  - HoLMiR-Hohenheim Center for Livestock Microbiome Research, University of 
      Hohenheim, Stuttgart, Germany.
FAU - Burkard, Markus
AU  - Burkard M
AD  - Department of Nutritional Biochemistry, University of Hohenheim, Stuttgart, 
      Germany.
FAU - Helling, Thomas
AU  - Helling T
AD  - Department of Nutritional Biochemistry, University of Hohenheim, Stuttgart, 
      Germany.
FAU - Biendl, Martin
AU  - Biendl M
AD  - HHV Hallertauer Hopfenveredelungsgesellschaft m.b.H, Mainburg, Germany.
FAU - Venturelli, Sascha
AU  - Venturelli S
AD  - Department of Nutritional Biochemistry, University of Hohenheim, Stuttgart, 
      Germany.
AD  - Department of Vegetative and Clinical Physiology, University Hospital of 
      Tuebingen, Tuebingen, Germany.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20231109
PL  - United States
TA  - Crit Rev Food Sci Nutr
JT  - Critical reviews in food science and nutrition
JID - 8914818
SB  - IM
OTO - NOTNLM
OT  - HCV
OT  - Nutrition
OT  - PRRSV
OT  - SARS-CoV-2
OT  - Xanthohumol
OT  - prenylflavonoids
OT  - viral inhibition
OT  - virology
EDAT- 2023/11/09 12:42
MHDA- 2023/11/09 12:42
CRDT- 2023/11/09 08:03
PHST- 2023/11/09 12:42 [medline]
PHST- 2023/11/09 12:42 [pubmed]
PHST- 2023/11/09 08:03 [entrez]
AID - 10.1080/10408398.2023.2275169 [doi]
PST - aheadofprint
SO  - Crit Rev Food Sci Nutr. 2023 Nov 9:1-15. doi: 10.1080/10408398.2023.2275169.