PMID- 37944124
OWN - NLM
STAT- MEDLINE
DCOM- 20240115
LR  - 20240115
IS  - 1520-5851 (Electronic)
IS  - 0013-936X (Print)
IS  - 0013-936X (Linking)
VI  - 57
IP  - 48
DP  - 2023 Dec 5
TI  - Exposure to a Mixture of Endocrine-Disrupting Chemicals and Metabolic Outcomes in 
      Belgian Adolescents.
PG  - 19871-19880
LID - 10.1021/acs.est.3c07607 [doi]
AB  - Childhood exposure to endocrine-disrupting chemicals (EDCs), either alone or in 
      mixtures, may affect metabolic outcomes, yet existing evidence remains 
      inconclusive. In our study of 372 adolescents from the Flemish Environment and 
      Health Study (FLEHS IV, 2017-2018), we measured 40 known and suspected EDCs and 
      assessed metabolic outcomes, including body mass index z-score (zBMI), abdominal 
      obesity (AO), total cholesterol (TC), and triglycerides (TG). We applied Bayesian 
      kernel machine regression (BKMR) and Bayesian penalized horseshoe regression for 
      variable selection and then built multivariate generalized propensity score 
      (mvGPS) models to provide an overview of the effects of selected EDCs on 
      metabolic outcomes. As a result, BKMR and horseshoe together identified five EDCs 
      associated with zBMI, three with AO, three with TC, and five with TG. Through 
      mvGPS analysis, monoiso-butyl phthalate (MIBP), polychlorinated biphenyl 
      (PCB-170), and hexachlorobenzene (HCB) each showed an inverse association with 
      zBMI, as did PCB-170 with AO. Copper (Cu) was associated with higher TC and TG, 
      except in boys where it was linked to lower TG. Additionally, monoethyl phthalate 
      (MEP) and monobenzyl phthalate (MBzP) were associated with higher TG. To 
      conclude, our findings support the association between certain chemicals (Cu, 
      MEP, and MBzP) and elevated lipid levels, aligning with prior studies. Further 
      investigation is needed for sex-specific effects.
FAU - Cai, Anran
AU  - Cai A
AUID- ORCID: 0000-0002-1463-1810
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht 3584 CM, The Netherlands.
AD  - VITO Health, Flemish Institute for Technological Research (VITO), Mol 2400, 
      Belgium.
FAU - Remy, Sylvie
AU  - Remy S
AD  - VITO Health, Flemish Institute for Technological Research (VITO), Mol 2400, 
      Belgium.
FAU - Lenters, Virissa
AU  - Lenters V
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht 3584 CM, The Netherlands.
AD  - Amsterdam Institute for Life and Environment, Department of Environment and 
      Health, Vrije Universiteit Amsterdam, Amsterdam 1081 HV, The Netherlands.
FAU - Cox, Bianca
AU  - Cox B
AD  - VITO Health, Flemish Institute for Technological Research (VITO), Mol 2400, 
      Belgium.
FAU - Schoeters, Greet
AU  - Schoeters G
AD  - Department of Biomedical Sciences, University of Antwerp, Antwerp 2000, Belgium.
FAU - Covaci, Adrian
AU  - Covaci A
AUID- ORCID: 0000-0003-0527-1136
AD  - Toxicological Centre, University of Antwerp, Wilrijk 2610, Belgium.
FAU - Vermeulen, Roel
AU  - Vermeulen R
AUID- ORCID: 0000-0003-4082-8163
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht 3584 CM, The Netherlands.
AD  - Julius Center for Health Sciences and Primary Care, University Medical Center 
      Utrecht, Utrecht 3584 CG, The Netherlands.
FAU - Portengen, Lutzen
AU  - Portengen L
AD  - Institute for Risk Assessment Sciences, Department of Population Health Sciences, 
      Utrecht University, Utrecht 3584 CM, The Netherlands.
LA  - eng
PT  - Clinical Study
PT  - Journal Article
DEP - 20231109
PL  - United States
TA  - Environ Sci Technol
JT  - Environmental science & technology
JID - 0213155
RN  - 2I988FUS7H (2,2',3,3',4,4',5-heptachlorobiphenyl)
RN  - 0 (Endocrine Disruptors)
RN  - 0 (Environmental Pollutants)
RN  - 0 (monoethyl phthalate)
RN  - 6O7F7IX66E (phthalic acid)
RN  - 0 (Phthalic Acids)
SB  - IM
MH  - Adolescent
MH  - Child
MH  - Female
MH  - Humans
MH  - Male
MH  - Bayes Theorem
MH  - Belgium
MH  - *Endocrine Disruptors
MH  - Environmental Exposure
MH  - *Environmental Pollutants
MH  - *Phthalic Acids
PMC - PMC10702523
OTO - NOTNLM
OT  - abdominal obesity
OT  - adolescence
OT  - body mass index
OT  - cholesterol
OT  - endocrine-disrupting chemicals
OT  - triglycerides
COIS- The authors declare no competing financial interest.
EDAT- 2023/11/09 18:42
MHDA- 2023/12/07 12:42
PMCR- 2023/12/07
CRDT- 2023/11/09 16:33
PHST- 2023/12/07 12:42 [medline]
PHST- 2023/11/09 18:42 [pubmed]
PHST- 2023/11/09 16:33 [entrez]
PHST- 2023/12/07 00:00 [pmc-release]
AID - 10.1021/acs.est.3c07607 [doi]
PST - ppublish
SO  - Environ Sci Technol. 2023 Dec 5;57(48):19871-19880. doi: 10.1021/acs.est.3c07607. 
      Epub 2023 Nov 9.