PMID- 37944891
OWN - NLM
STAT- MEDLINE
DCOM- 20240108
LR  - 20240108
IS  - 1873-6424 (Electronic)
IS  - 0269-7491 (Linking)
VI  - 341
DP  - 2024 Jan 15
TI  - Combined effects of organochlorine pesticides on type 2 diabetes mellitus: 
      Insights from endocrine disrupting effects of hormones.
PG  - 122867
LID - S0269-7491(23)01869-9 [pii]
LID - 10.1016/j.envpol.2023.122867 [doi]
AB  - Association between organochlorine pesticides (OCPs) exposure and type 2 diabetes 
      mellitus (T2DM) remains contradictory, and the evidence is mostly focused on a 
      single exposure. Here, we assessed the associations between individual and 
      combined OCPs exposure and T2DM, and explored the underlying mechanism of sex 
      hormones and the methylation levels of sex hormone receptors in above 
      associations. A case-control study with 1812 participants was performed. Gas 
      chromatography mass spectrometry, liquid chromatography-tandem mass spectrometry, 
      and pyrosequencing were used to measure plasma OCPs, serum sex hormones, and 
      whole blood methylation levels of sex hormone receptors, respectively. 
      Generalized linear models were used to analyze the relationships between OCPs, 
      sex hormones, the methylation levels of sex hormone receptors, and T2DM. Quantile 
      based g-computation (QGC) and Bayesian Kernel Machine Regression (BKMR) were 
      employed to assess the combined OCPs exposure. The roles of sex hormones and the 
      methylation levels of their receptors were evaluated by moderating mediation 
      models. After adjusting for covariates, each unit (2.718 ng/ml) increase in 
      p,p'-DDE was associated with a higher risk of T2DM in males (odds ratio (OR) and 
      95% confidence interval (CI): 1.066 (1.023, 1.112)). QGC and BKMR showed a 
      positive combined effect in the associations of OCPs mixtures on T2DM among 
      premenopausal females, and positive effects but not statistically significant 
      among males and postmenopausal females. p,p'-DDE was the largest contributor for 
      the positive associations. Furthermore, testosterone mediated 21.149% of the 
      associations of p,p'-DDE with T2DM moderated by the androgen receptor methylation 
      (ARm) located in CpG island 1. Individual and mixtures of OCPs exposure were 
      positively linked to elevated risk of T2DM. Testosterone and ARm may participate 
      in the related processes of OCPs with T2DM, providing new insights into the 
      adverse endocrine effects caused by OCPs and specific pathways for the etiology 
      and control of diabetes.
CI  - Copyright (c) 2023 Elsevier Ltd. All rights reserved.
FAU - Shi, Jiayu
AU  - Shi J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Wei, Dandan
AU  - Wei D
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Ma, Cuicui
AU  - Ma C
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Geng, Jintian
AU  - Geng J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Zhao, Mengzhen
AU  - Zhao M
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Hou, Jian
AU  - Hou J
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Huo, Wenqian
AU  - Huo W
AD  - Department of Occupational and Environmental Health Sciences, College of Public 
      Health, Zhengzhou University, Zhengzhou, Henan, PR China.
FAU - Jing, Tao
AU  - Jing T
AD  - School of Public Health, Tongji Medical College, Huazhong University of Science 
      and Technology, Wuhan, Hubei, PR China.
FAU - Wang, Chongjian
AU  - Wang C
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China.
FAU - Mao, Zhenxing
AU  - Mao Z
AD  - Department of Epidemiology and Biostatistics, College of Public Health, Zhengzhou 
      University, Zhengzhou, Henan, PR China. Electronic address: mzx@zzu.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231107
PL  - England
TA  - Environ Pollut
JT  - Environmental pollution (Barking, Essex : 1987)
JID - 8804476
RN  - 4M7FS82U08 (Dichlorodiphenyl Dichloroethylene)
RN  - 0 (Hydrocarbons, Chlorinated)
RN  - 0 (Pesticides)
RN  - 3XMK78S47O (Testosterone)
RN  - 0 (Gonadal Steroid Hormones)
SB  - IM
MH  - Male
MH  - Female
MH  - Humans
MH  - Dichlorodiphenyl Dichloroethylene/analysis
MH  - *Diabetes Mellitus, Type 2/chemically induced
MH  - Case-Control Studies
MH  - Bayes Theorem
MH  - *Hydrocarbons, Chlorinated/analysis
MH  - *Pesticides/analysis
MH  - Testosterone
MH  - Gonadal Steroid Hormones
OTO - NOTNLM
OT  - Combined exposure
OT  - Methylation
OT  - Organochlorine pesticides
OT  - Testosterone
OT  - Type 2 diabetes mellitus
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/10 00:44
MHDA- 2024/01/08 06:42
CRDT- 2023/11/09 19:19
PHST- 2023/08/16 00:00 [received]
PHST- 2023/10/12 00:00 [revised]
PHST- 2023/11/02 00:00 [accepted]
PHST- 2024/01/08 06:42 [medline]
PHST- 2023/11/10 00:44 [pubmed]
PHST- 2023/11/09 19:19 [entrez]
AID - S0269-7491(23)01869-9 [pii]
AID - 10.1016/j.envpol.2023.122867 [doi]
PST - ppublish
SO  - Environ Pollut. 2024 Jan 15;341:122867. doi: 10.1016/j.envpol.2023.122867. Epub 
      2023 Nov 7.