PMID- 37945623
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231113
IS  - 2045-2322 (Electronic)
IS  - 2045-2322 (Linking)
VI  - 13
IP  - 1
DP  - 2023 Nov 9
TI  - Changes in peripapillary microvasculature in patients with type 2 diabetes 
      patients: effect of systemic hypertension.
PG  - 19459
LID - 10.1038/s41598-023-46374-8 [doi]
LID - 19459
AB  - To determine the effect of hypertension (HTN) on the peripapillary 
      microvasculature in type 2 diabetes mellitus (T2DM) patients without diabetic 
      retinopathy (DR). The patients were classified into three groups: the control 
      group (group 1), T2DM group (group 2), and both T2DM and HTN group (group 3). 
      Peripapillary vessel density (VD) was compared using analysis of covariance and 
      linear regression analysis was performed to identify the factors affecting the 
      peripapillary VD. A total of 286 eyes were enrolled: 124 in group 1, 111 in group 
      2, and 51 in group 3. The peripapillary VDs for the full area were 18.3 +/- 0.6, 
      17.8 +/- 1.0, and 17.3 +/- 1.2 mm(-1) in group 1, group 2, and group 3, respectively, 
      which were significantly different after adjustment for age and best-corrected 
      visual acuity (P < 0.001). In post hoc analyses, group 1 versus group 2 
      (P < 0.001), group 1 versus group 3 (P < 0.001), and group 2 versus group 3 
      (P = 0.001) showed significant differences. In linear regression analysis, HTN 
      (B =  - 0.352, P = 0.043) and peripapillary retinal nerve fiber layer (pRNFL) 
      thickness (B = 0.045, P < 0.001) were significantly associated with peripapillary 
      VD in T2DM patients. Peripapillary VD in T2DM patients without clinical DR were 
      lower compared to normal controls, and they were more decreased when HTN was 
      comorbid. The combination of ischemic damage by high blood pressure and 
      impairment of the neurovascular unit by hyperglycemia would result in more severe 
      deterioration of peripapillary microvasculature, and this impairment could be 
      also reflected by pRNFL thinning.
CI  - (c) 2023. The Author(s).
FAU - Sung, Jae-Yun
AU  - Sung JY
AD  - Department of Ophthalmology, Chungnam National University Sejong Hospital, 
      Sejong, Republic of Korea.
FAU - Lee, Kook-Hyung
AU  - Lee KH
AD  - Department of Ophthalmology, Konyang University College of Medicine, #1643 
      Gwanjeo-dong, Seo-gu, Daejeon, Republic of Korea.
FAU - Jun, Ji-Ho
AU  - Jun JH
AD  - Department of Ophthalmology, Konyang University College of Medicine, #1643 
      Gwanjeo-dong, Seo-gu, Daejeon, Republic of Korea.
FAU - Lee, Min-Woo
AU  - Lee MW
AD  - Department of Ophthalmology, Konyang University College of Medicine, #1643 
      Gwanjeo-dong, Seo-gu, Daejeon, Republic of Korea. bogus1105@gmail.com.
LA  - eng
PT  - Journal Article
DEP - 20231109
PL  - England
TA  - Sci Rep
JT  - Scientific reports
JID - 101563288
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/complications
MH  - Retinal Ganglion Cells
MH  - Retinal Vessels
MH  - *Hypertension/complications
MH  - *Diabetic Retinopathy
MH  - Microvessels
MH  - Tomography, Optical Coherence
PMC - PMC10636028
COIS- The authors declare no competing interests.
EDAT- 2023/11/10 00:44
MHDA- 2023/11/13 06:42
PMCR- 2023/11/09
CRDT- 2023/11/09 23:27
PHST- 2023/08/10 00:00 [received]
PHST- 2023/10/31 00:00 [accepted]
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/11/10 00:44 [pubmed]
PHST- 2023/11/09 23:27 [entrez]
PHST- 2023/11/09 00:00 [pmc-release]
AID - 10.1038/s41598-023-46374-8 [pii]
AID - 46374 [pii]
AID - 10.1038/s41598-023-46374-8 [doi]
PST - epublish
SO  - Sci Rep. 2023 Nov 9;13(1):19459. doi: 10.1038/s41598-023-46374-8.