PMID- 37945912
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231207
IS  - 1436-5073 (Electronic)
IS  - 0026-3672 (Linking)
VI  - 190
IP  - 12
DP  - 2023 Nov 9
TI  - NIR-II fluorescent Ag(2)Se polystyrene beads in a lateral flow immunoassay to 
      detect biomarkers for breast cancer.
PG  - 462
LID - 10.1007/s00604-023-06039-9 [doi]
AB  - Fluorescent lateral flow immunoassay (LFA), one tool in point of care testing 
      (POCT) systems for breast cancer, has attracted attention because it is quick, 
      simple, and convenient. However, samples and the constituent material exhibit 
      autofluorescence in the visible region, which is a very large obstacle in the 
      development of fluorescent LFAs. The autofluorescence of biological samples is 
      scarcely found in the second near-infrared (NIR-II) range and samples scatter and 
      absorb less NIR-II light than visible light. Here, we report an NIR-II QD-LFA 
      platform using the NIR-II fluorescent Ag(2)Se quantum dots (QDs) with 1020 nm 
      emission encapsulated into polystyrene beads as fluorescent probes. The NIR-II 
      LFA platform was established to detect breast cancer tumour markers (CEA and 
      CA153) within 15 min with a low limit of detection (CEA: 0.768 ng mL(-1), CA153: 
      1.192 U mL(-1)), high recoveries (93.7% ~ 108.8%), and relative standard 
      deviations (RSDs) of less than 10%. This study demonstrated the potential of 
      NIR-II Ag(2)Se polystyrene beads as a fluorescent probe in LFA for rapid and 
      accurate identification of biomarkers. They are suited for use in professional 
      situations.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer-Verlag GmbH Austria, 
      part of Springer Nature.
FAU - Deng, Kuhan
AU  - Deng K
AD  - College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, 
      China.
FAU - Yu, Zi-Li
AU  - Yu ZL
AD  - State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key 
      Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of 
      Stomatology, Department of Oral and Maxillofacial Surgery, School & Hospital of 
      Stomatology, Wuhan University, Wuhan, 430079, China.
FAU - Hu, Xiaofeng
AU  - Hu X
AD  - Hubei Hongshan Lab, Key Laboratory of Biology and Genetic Improvement of Oil 
      Crops, Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, 
      Wuhan, 430062, China.
FAU - Liu, Jing
AU  - Liu J
AD  - College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, 
      China.
FAU - Hong, Xuechuan
AU  - Hong X
AD  - Key Laboratory of Environmental Engineering and Pollution Control On Plateau 
      (Tibet Autonomous Region), School of Ecology and Environment, Tibet University, 
      Lhasa, 850000, China.
FAU - Zi, Gong Ga Lan
AU  - Zi GGL
AD  - Medical College, Tibet University, Lhasa, 850000, China.
FAU - Zhang, Zhaowei
AU  - Zhang Z
AD  - Hubei Hongshan Lab, Key Laboratory of Biology and Genetic Improvement of Oil 
      Crops, Oil Crops Research Institute of Chinese Academy of Agricultural Sciences, 
      Wuhan, 430062, China. zwzhang@whu.edu.cn.
FAU - Tian, Zhi-Quan
AU  - Tian ZQ
AD  - College of Chemistry and Molecular Sciences, Wuhan University, Wuhan, 430072, 
      China. zqtian@whu.edu.cn.
AD  - Key Laboratory of Environmental Engineering and Pollution Control On Plateau 
      (Tibet Autonomous Region), School of Ecology and Environment, Tibet University, 
      Lhasa, 850000, China. zqtian@whu.edu.cn.
LA  - eng
GR  - 91959103/National Natural Science Foundation of China/
GR  - 81801842/National Natural Science Foundation of China/
GR  - XZ202102YD0033C/Central Government Funds for Local Science and Technology 
      Development/
GR  - XZ202202YD0021C/Central Government Funds for Local Science and Technology 
      Development/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20231109
PL  - Austria
TA  - Mikrochim Acta
JT  - Mikrochimica acta
JID - 7808782
RN  - 0 (Polystyrenes)
RN  - 0 (Biomarkers, Tumor)
RN  - 0 (Fluorescent Dyes)
SB  - IM
MH  - *Polystyrenes
MH  - Biomarkers, Tumor
MH  - Fluorescent Dyes
MH  - Immunoassay
MH  - Light
MH  - *Neoplasms
OTO - NOTNLM
OT  - Ag2Se QDs
OT  - Biomarkers
OT  - Breast cancer
OT  - Lateral flow immunoassay
OT  - NIR-II
EDAT- 2023/11/10 00:44
MHDA- 2023/11/13 06:42
CRDT- 2023/11/09 23:50
PHST- 2023/05/29 00:00 [received]
PHST- 2023/10/10 00:00 [accepted]
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/11/10 00:44 [pubmed]
PHST- 2023/11/09 23:50 [entrez]
AID - 10.1007/s00604-023-06039-9 [pii]
AID - 10.1007/s00604-023-06039-9 [doi]
PST - epublish
SO  - Mikrochim Acta. 2023 Nov 9;190(12):462. doi: 10.1007/s00604-023-06039-9.