PMID- 37946371
OWN - NLM
STAT- MEDLINE
DCOM- 20231115
LR  - 20231115
IS  - 0973-7138 (Electronic)
IS  - 0250-5991 (Linking)
VI  - 48
DP  - 2023
TI  - ESE-1 mediates lipopolysaccharide-induced BV2 cell inflammation via upregulation 
      of HMGB1 expression.
LID - 43 [pii]
AB  - Microglial inflammation is characterized by an increase in proinflammatory 
      cytokines and proinflammatory enzyme levels, facilitating inflammation-mediated 
      neuronal apoptosis. Previous studies indicated that both high-mobility group 
      protein B1 (HMGB1) and E26 transformation-specific sequence (ETS) transcription 
      factor-1 (ESE-1) are involved in lipopolysaccharide (LPS)-mediated 
      neuroinflammation. In the present study, we hypothesized that the ESE-1 modulates 
      HMGB1 expression and is thus involved in LPS-mediated microglial inflammation. 
      Moreover, we explored the potential mechanism by which ESE-1 modulates HMGB1 
      expression. Our study indicated that LPS increased proinflammatory cytokine and 
      proinflammatory enzyme levels via upregulation of HMGB1 expression in BV2 cells. 
      Moreover, LPS treatment increased ESE-1 expression while inhibiting sirt1 
      expression. Both sirt1 overexpression and si-ESE-1 treatment reversed LPSinduced 
      HMGB1 expression and proinflammatory cytokine and proinflammatory enzyme levels. 
      In addition, ESE-1 was found to be associated with sirt1. Also ESE-1 and sirt1 
      were found to be enriched with the HMGB1 promoter region. Sirt1 silencing 
      increased the abundance of ESE-1 that occupied the HMGB1 promoter region. The 
      present study indicated that ESE-1 associates with sirt1 to regulate HMGB1 
      expression, which participates in LPS-mediated inflammation in BV2 cells.
FAU - Lu, Yaojun
AU  - Lu Y
AD  - Department of Anaesthesiology, The Obstetrics and Gynecology Hospital of Fudan 
      University, No. 128 Shenyang Road, Shanghai 200090, China.
FAU - Ding, Juan
AU  - Ding J
FAU - Huang, Jiaojiao
AU  - Huang J
FAU - Zhao, Yanjun
AU  - Zhao Y
LA  - eng
PT  - Journal Article
PL  - India
TA  - J Biosci
JT  - Journal of biosciences
JID - 8100809
RN  - 0 (Cytokines)
RN  - 0 (HMGB1 Protein)
RN  - 0 (Lipopolysaccharides)
RN  - EC 3.5.1.- (Sirtuin 1)
RN  - 0 (HMGB1 protein, human)
RN  - 0 (ELF3 protein, human)
SB  - IM
MH  - Humans
MH  - Cytokines/genetics/metabolism
MH  - *HMGB1 Protein/genetics
MH  - Inflammation/chemically induced/genetics
MH  - *Lipopolysaccharides/pharmacology
MH  - Sirtuin 1/genetics/metabolism
MH  - Up-Regulation
EDAT- 2023/11/10 06:45
MHDA- 2023/11/13 06:43
CRDT- 2023/11/10 00:42
PHST- 2023/11/13 06:43 [medline]
PHST- 2023/11/10 06:45 [pubmed]
PHST- 2023/11/10 00:42 [entrez]
AID - 43 [pii]
PST - ppublish
SO  - J Biosci. 2023;48:43.