PMID- 37946482
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231113
IS  - 2589-451X (Electronic)
IS  - 0255-2922 (Print)
IS  - 0255-2922 (Linking)
VI  - 43
IP  - 6
DP  - 2023 Oct
TI  - Bo's abdominal acupuncture improves disordered metabolism in obese type 2 
      diabetic rats through regulating fibroblast growth factor 21 and its related 
      adipokines.
PG  - 1200-1208
LID - 10.19852/j.cnki.jtcm.20231008.002 [doi]
AB  - OBJECTIVE: To investigate the effect of Bo's abdominal acupuncture (BOAA) on 
      fibroblast growth factor 21 (FGF21) and its related adipokines in type 2 diabetes 
      mellitus (T2DM) rats. METHODS: This study established obese T2DM rat model by 
      high-fat diet (HFD) with a dose of streptozotocin (STZ, 30 mg/kg). Obese T2DM 
      rats were randomly subdivided into four groups (n = 10): negative, BOAA, 
      conventional acupuncture (COA group) and metformin group (Met group) groups. The 
      biochemical parameters, mRNAs, and proteins were analyzed using enzyme-lined 
      immunoassays kits, quantitative polymerase chain reaction and Western blot. 
      RESULTS: Treatment with BOAA attenuated the histopathological changes in visceral 
      fat and restored the alterations in the levels of body weight, fasting blood 
      glucose (FBG), homeostasis model assessment for insulin resistance (HOMA-IR). 
      BOAA treatment significantly decreased the levels of triglyceride, total 
      cholesterol, low density lipoprotein cholesterol, leptin, and increased the serum 
      levels of high-density lipoprotein cholesterol, fibroblast growth factor 21 
      (FGF21), adiponectin (ADP), peroxisome proliferator-activated receptor gamma 
      (PPAR-gamma), C-peptide (C-P) in obese T2DM rats. Furthermore, BOAA treatment 
      significantly increased the mRNA expressions of FGF21, ADP, leptin, PPAR-gamma, 
      PPAR-alpha and adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK). 
      Besides, BOAA treatment upregulated the protein expressions of fibroblast growth 
      factor receptors3 (FGFR3), PPAR-alpha, extracellular signal-regulated kinase (ERK), 
      phosphorylated ERK (p-ERK), AMPK, p-AMPK, Liver kinase B1 (LKB1), phosphorylated 
      LKB1 (p-LKB1), acetyl-CoA carboxylase (ACC) and phosphorylated ACC (p-ACC), while 
      downregulated the protein expressions of FGF21 and PPAR-gamma in visceral fat. 
      CONCLUSIONS: BOAA treatment reduced FBG and body weight, and improved insulin 
      sensitivity through regulating FGF21 signaling pathway and its related adipokine 
      in obese T2DM rats.
FAU - Xihui, Qin
AU  - Xihui Q
AD  - School of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, 
      China.
FAU - Jianli, Pang
AU  - Jianli P
AD  - Department of Endocrinology, Ruikang Hospital Affiliated to Guangxi University of 
      Traditional Chinese Medicine, Nanning 530011, China.
FAU - Guan, Xiong
AU  - Guan X
AD  - Department of Gynecology and obstetrics, the Eighth People's Hospital of Nanning, 
      Nanning 530007, China.
FAU - Jie, Feng
AU  - Jie F
AD  - School of Pharmaceutical Sciences, Guangxi Medical University, Nanning 530021, 
      China.
LA  - eng
GR  - 81560731/National Natural Science Foundation of China/
PT  - Journal Article
PL  - China
TA  - J Tradit Chin Med
JT  - Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan
JID - 8211546
RN  - 0 (fibroblast growth factor 21)
RN  - 0 (Leptin)
RN  - 0 (Adipokines)
RN  - EC 2.7.11.31 (AMP-Activated Protein Kinases)
RN  - 0 (Peroxisome Proliferator-Activated Receptors)
RN  - 62031-54-3 (Fibroblast Growth Factors)
RN  - 97C5T2UQ7J (Cholesterol)
SB  - IM
MH  - Rats
MH  - Animals
MH  - *Diabetes Mellitus, Type 2/complications/therapy/metabolism
MH  - Leptin
MH  - Adipokines
MH  - AMP-Activated Protein Kinases/genetics/metabolism
MH  - *Diabetes Mellitus, Experimental/complications/therapy
MH  - Peroxisome Proliferator-Activated Receptors
MH  - Obesity/complications/therapy
MH  - Fibroblast Growth Factors/genetics/metabolism
MH  - Body Weight
MH  - *Insulin Resistance
MH  - *Acupuncture Therapy
MH  - Diet, High-Fat/adverse effects
MH  - Cholesterol
PMC - PMC10623386
OTO - NOTNLM
OT  - Bo's abdominal acupuncture
OT  - adipokines
OT  - diabetes mellitus, type 2
OT  - fibroblast growth factors
OT  - insulin resistance
OT  - obesity
EDAT- 2023/11/10 06:45
MHDA- 2023/11/13 06:42
PMCR- 2023/10/25
CRDT- 2023/11/10 03:39
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/11/10 06:45 [pubmed]
PHST- 2023/11/10 03:39 [entrez]
PHST- 2023/10/25 00:00 [pmc-release]
AID - 1698986639244-1741119160 [pii]
AID - JTCM-43-6-1200 [pii]
AID - 10.19852/j.cnki.jtcm.20231008.002 [doi]
PST - ppublish
SO  - J Tradit Chin Med. 2023 Oct;43(6):1200-1208. doi: 
      10.19852/j.cnki.jtcm.20231008.002.