PMID- 37947386
OWN - NLM
STAT- MEDLINE
DCOM- 20240117
LR  - 20240201
IS  - 2059-2310 (Electronic)
IS  - 2059-2302 (Linking)
VI  - 103
IP  - 1
DP  - 2024 Jan
TI  - 18th International HLA and Immunogenetics Workshop: Report on the SNP-HLA 
      Reference Consortium (SHLARC) component.
PG  - e15293
LID - 10.1111/tan.15293 [doi]
AB  - The SNP-HLA Reference Consortium (SHLARC), a component of the 18th International 
      HLA and Immunogenetics Workshop, is aimed at collecting diverse and extensive 
      human leukocyte antigen (HLA) data to create custom reference panels and enhance 
      HLA imputation techniques. Genome-wide association studies (GWAS) have 
      significantly contributed to identifying genetic associations with various 
      diseases. The HLA genomic region has emerged as the top locus in GWAS, 
      particularly in immune-related disorders. However, the limited information 
      provided by single nucleotide polymorphisms (SNPs), the hallmark of GWAS, poses 
      challenges, especially in the HLA region, where strong linkage disequilibrium 
      (LD) spans several megabases. HLA imputation techniques have been developed using 
      statistical inference in response to these challenges. These techniques enable 
      the prediction of HLA alleles from genotyped GWAS SNPs. Here we present the 
      SHLARC activities, a collaborative effort to create extensive, and multi-ethnic 
      reference panels to enhance HLA imputation accuracy.
CI  - (c) 2023 The Authors. HLA: Immune Response Genetics published by John Wiley & Sons 
      Ltd.
FAU - Silva, Nayane S B
AU  - Silva NSB
AUID- ORCID: 0000-0001-5511-8426
AD  - Center for Research in Transplantation and Translational Immunology, Nantes 
      Universite, INSERM, Ecole Centrale Nantes, Nantes, France.
AD  - Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Sao Paulo 
      State University - Unesp, Botucatu, Brazil.
FAU - Bourguiba-Hachemi, Sonia
AU  - Bourguiba-Hachemi S
AUID- ORCID: 0000-0002-2452-2861
AD  - Center for Research in Transplantation and Translational Immunology, Nantes 
      Universite, INSERM, Ecole Centrale Nantes, Nantes, France.
FAU - Douillard, Venceslas
AU  - Douillard V
AUID- ORCID: 0000-0002-6762-4083
AD  - Center for Research in Transplantation and Translational Immunology, Nantes 
      Universite, INSERM, Ecole Centrale Nantes, Nantes, France.
FAU - Koskela, Satu
AU  - Koskela S
AUID- ORCID: 0000-0001-9258-9163
AD  - Finnish Red Cross Blood Service Biobank, Helsinki, Finland.
FAU - Degenhardt, Frauke
AU  - Degenhardt F
AUID- ORCID: 0000-0001-7516-3179
AD  - Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, 
      University Hospital Schleswig Holstein - Campus Kiel, Kiel, Germany.
FAU - Clancy, Jonna
AU  - Clancy J
AUID- ORCID: 0000-0002-0568-6676
AD  - Finnish Red Cross Blood Service Biobank, Helsinki, Finland.
FAU - Limou, Sophie
AU  - Limou S
AUID- ORCID: 0000-0002-7702-8234
AD  - Center for Research in Transplantation and Translational Immunology, Nantes 
      Universite, INSERM, Ecole Centrale Nantes, Nantes, France.
FAU - Meyer, Diogo
AU  - Meyer D
AUID- ORCID: 0000-0002-7155-5674
AD  - Department of Genetics and Evolutionary Biology, Biosciences Institute, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Masotti, Cibele
AU  - Masotti C
AUID- ORCID: 0000-0003-4462-0941
AD  - Molecular Oncology Center, Hospital Sirio-Libanes, Sao Paulo, Brazil.
FAU - Knorst, Stefan
AU  - Knorst S
AD  - Molecular Oncology Center, Hospital Sirio-Libanes, Sao Paulo, Brazil.
FAU - Naslavsky, Michel Satya
AU  - Naslavsky MS
AUID- ORCID: 0000-0002-9068-1713
AD  - Department of Genetics and Evolutionary Biology, Biosciences Institute, 
      University of Sao Paulo, Sao Paulo, Brazil.
FAU - Franke, Andre
AU  - Franke A
AD  - Institute of Clinical Molecular Biology, Christian-Albrechts-University Kiel, 
      University Hospital Schleswig Holstein - Campus Kiel, Kiel, Germany.
FAU - Castelli, Erick C
AU  - Castelli EC
AUID- ORCID: 0000-0003-2142-7196
AD  - Molecular Genetics and Bioinformatics Laboratory, School of Medicine, Sao Paulo 
      State University - Unesp, Botucatu, Brazil.
FAU - Gourraud, Pierre-Antoine
AU  - Gourraud PA
AUID- ORCID: 0000-0003-1131-9554
AD  - Center for Research in Transplantation and Translational Immunology, Nantes 
      Universite, INSERM, Ecole Centrale Nantes, Nantes, France.
FAU - Vince, Nicolas
AU  - Vince N
AUID- ORCID: 0000-0002-3767-6210
AD  - Center for Research in Transplantation and Translational Immunology, Nantes 
      Universite, INSERM, Ecole Centrale Nantes, Nantes, France.
LA  - eng
GR  - European Union (via the FEDER) under the Programme of Investments for the Future/
GR  - European Union's Horizon 2020 research and innovation program/
GR  - INSERM/
GR  - Nantes Metropole, the Pays de la Loire Region/
PT  - Journal Article
DEP - 20231110
PL  - England
TA  - HLA
JT  - HLA
JID - 101675570
RN  - 0 (HLA Antigens)
SB  - IM
MH  - Humans
MH  - *Polymorphism, Single Nucleotide
MH  - *Genome-Wide Association Study
MH  - Immunogenetics
MH  - Alleles
MH  - HLA Antigens/genetics
MH  - Genotype
OTO - NOTNLM
OT  - 18th International HLA and Immunogenetics Workshop
OT  - HLA
OT  - SHLARC
OT  - SNP
OT  - imputation
OT  - reference panel
EDAT- 2023/11/10 12:43
MHDA- 2024/01/17 06:42
CRDT- 2023/11/10 08:43
PHST- 2023/10/24 00:00 [revised]
PHST- 2023/06/14 00:00 [received]
PHST- 2023/11/01 00:00 [accepted]
PHST- 2024/01/17 06:42 [medline]
PHST- 2023/11/10 12:43 [pubmed]
PHST- 2023/11/10 08:43 [entrez]
AID - 10.1111/tan.15293 [doi]
PST - ppublish
SO  - HLA. 2024 Jan;103(1):e15293. doi: 10.1111/tan.15293. Epub 2023 Nov 10.