PMID- 37947609
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20240201
IS  - 2073-4409 (Electronic)
IS  - 2073-4409 (Linking)
VI  - 12
IP  - 21
DP  - 2023 Oct 27
TI  - Advancing Alzheimer's Therapeutics: Exploring the Impact of Physical Exercise in 
      Animal Models and Patients.
LID - 10.3390/cells12212531 [doi]
LID - 2531
AB  - Alzheimer's disease (AD) is the main neurodegenerative disorder characterized by 
      several pathophysiological features, including the misfolding of the tau protein 
      and the amyloid beta (Abeta) peptide, neuroinflammation, oxidative stress, synaptic 
      dysfunction, metabolic alterations, and cognitive impairment. These mechanisms 
      collectively contribute to neurodegeneration, necessitating the exploration of 
      therapeutic approaches with multiple targets. Physical exercise has emerged as a 
      promising non-pharmacological intervention for AD, with demonstrated effects on 
      promoting neurogenesis, activating neurotrophic factors, reducing Abeta aggregates, 
      minimizing the formation of neurofibrillary tangles (NFTs), dampening 
      inflammatory processes, mitigating oxidative stress, and improving the 
      functionality of the neurovascular unit (NVU). Overall, the neuroprotective 
      effects of exercise are not singular, but are multi-targets. Numerous studies 
      have investigated physical exercise's potential in both AD patients and animal 
      models, employing various exercise protocols to elucidate the underlying 
      neurobiological mechanisms and effects. The objective of this review is to 
      analyze the neurological therapeutic effects of these exercise protocols in 
      animal models and compare them with studies conducted in AD patients. By 
      translating findings from different approaches, this review aims to identify 
      opportune, specific, and personalized therapeutic windows, thus advancing 
      research on the use of physical exercise with AD patients.
FAU - Andrade-Guerrero, Jesus
AU  - Andrade-Guerrero J
AUID- ORCID: 0000-0002-0574-8814
AD  - Laboratorio de Patogenesis Molecular, Laboratorio 4, Edificio A4, Carrera Medico 
      Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma 
      de Mexico, Tlalnepantla 54090, Mexico.
AD  - Departamento de Neurobiologia del Desarrollo y Neurofisiologia, Instituto de 
      Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico.
FAU - Rodriguez-Arellano, Paola
AU  - Rodriguez-Arellano P
AD  - Departamento de Neurobiologia del Desarrollo y Neurofisiologia, Instituto de 
      Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico.
FAU - Barron-Leon, Nayeli
AU  - Barron-Leon N
AD  - Departamento de Neurobiologia del Desarrollo y Neurofisiologia, Instituto de 
      Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico.
FAU - Orta-Salazar, Erika
AU  - Orta-Salazar E
AD  - Departamento de Neurobiologia del Desarrollo y Neurofisiologia, Instituto de 
      Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico.
FAU - Ledesma-Alonso, Carlos
AU  - Ledesma-Alonso C
AD  - Departamento de Neurobiologia del Desarrollo y Neurofisiologia, Instituto de 
      Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico.
FAU - Diaz-Cintra, Sofia
AU  - Diaz-Cintra S
AD  - Departamento de Neurobiologia del Desarrollo y Neurofisiologia, Instituto de 
      Neurobiologia, Universidad Nacional Autonoma de Mexico, Queretaro 76230, Mexico.
FAU - Soto-Rojas, Luis O
AU  - Soto-Rojas LO
AUID- ORCID: 0000-0002-5013-3608
AD  - Laboratorio de Patogenesis Molecular, Laboratorio 4, Edificio A4, Carrera Medico 
      Cirujano, Facultad de Estudios Superiores Iztacala, Universidad Nacional Autonoma 
      de Mexico, Tlalnepantla 54090, Mexico.
AD  - Red MEDICI, Carrera Medico Cirujano, Facultad de Estudios Superiores Iztacala, 
      Universidad Nacional Autonoma de Mexico, Tlalnepantla 54090, Mexico.
LA  - eng
GR  - IA205423, IN206322/UNAM-PAPIIT/
GR  - 319433/Consejo Nacional de Humanidades, Ciencias y Tecnologias (CONAHCYT), 
      Ciencia Basica y/o Ciencia de Frontera Modalidad: Paradigmas y Controversias de 
      la Ciencia 2022/
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20231027
PL  - Switzerland
TA  - Cells
JT  - Cells
JID - 101600052
RN  - 0 (Amyloid beta-Peptides)
SB  - IM
MH  - Animals
MH  - Humans
MH  - *Alzheimer Disease/metabolism
MH  - Amyloid beta-Peptides/metabolism
MH  - Neurofibrillary Tangles/metabolism
MH  - Disease Models, Animal
MH  - Oxidative Stress
PMC - PMC10648553
OTO - NOTNLM
OT  - Alzheimer's disease
OT  - animal model
OT  - neuroprotection
OT  - physical activity
OT  - physical exercise
COIS- The authors declare no conflict of interest.
EDAT- 2023/11/10 12:44
MHDA- 2023/11/13 06:42
PMCR- 2023/10/27
CRDT- 2023/11/10 10:04
PHST- 2023/09/26 00:00 [received]
PHST- 2023/10/18 00:00 [revised]
PHST- 2023/10/25 00:00 [accepted]
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/11/10 12:44 [pubmed]
PHST- 2023/11/10 10:04 [entrez]
PHST- 2023/10/27 00:00 [pmc-release]
AID - cells12212531 [pii]
AID - cells-12-02531 [pii]
AID - 10.3390/cells12212531 [doi]
PST - epublish
SO  - Cells. 2023 Oct 27;12(21):2531. doi: 10.3390/cells12212531.