PMID- 37947780
OWN - NLM
STAT- PubMed-not-MEDLINE
LR  - 20231217
IS  - 1520-5827 (Electronic)
IS  - 0743-7463 (Linking)
VI  - 39
IP  - 46
DP  - 2023 Nov 21
TI  - Formation of Polyion Complex Aggregate Formed from a Cationic Block Copolymer and 
      Anionic Polysaccharide.
PG  - 16484-16493
LID - 10.1021/acs.langmuir.3c02404 [doi]
AB  - Block copolymers (P(m)M(n); P(20)M(101) and P(100)M(98)) comprising 
      poly(2-(methacryloyloxy)ethylphosphorylcholine) (PMPC, P) containing 
      biocompatible phosphorylcholin pendants and cationic poly((3-acryloylaminopropyl) 
      trimethylammonium chloride) (PMAPTAC, M) were synthesized via a controlled 
      radical polymerization method. The degrees of polymerization of the PMPC and 
      PMAPTAC segments are denoted by subscripts (P(m)M(n)). The mixture of cationic 
      P(m)M(n) and anionic sodium chondroitin sulfate C (CS) with the pendant anionic 
      carboxylate and sulfonate groups formed polyion complex (PIC) aggregates in 
      phosphate-buffered saline. A charge-neutralized mixture of P(20)M(101) with CS 
      formed P(20)M(101)/CS PIC vesicles with a hydrodynamic radius (R(h)) of 97.2 nm, 
      zeta potential of ca. 0 mV, and aggregation number (N(agg)) of 23,044. PMPC 
      shells covered the surface of the PIC vesicles. The mixture of P(100)M(98) and CS 
      formed PIC spherical micelles with the PIC core and hydrophilic PMPC shells. The 
      R(h), zeta potential, and N(agg) of the PIC micelles were 26.4 nm, ca. 0 mV, and 
      404, respectively. At pH < 4, the carboxylate anions in CS were protonated. Thus, 
      the charge balance in the PIC micelles shifted to decrease the core density owing 
      to the electrostatic repulsions of the excess cations in the core. The PIC 
      micelles dissociated at a NaCl concentration >/=0.6 M owing to the charge screening 
      effect. The positively charged PIC micelles with excess P(100)M(98) can 
      encapsulate anionic dyes owing to electrostatic interaction.
FAU - Ogata, Kazushi
AU  - Ogata K
AD  - Department of Applied Chemistry, Graduate School of Engineering, University of 
      Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan.
FAU - Hashizume, Mineo
AU  - Hashizume M
AUID- ORCID: 0000-0001-8162-5173
AD  - Department of Industrial Chemistry, Faculty of Engineering, Tokyo University of 
      Science, 6-3-1 Niijuku, Katsushika-ku, Tokyo 125-8585, Japan.
FAU - Takahashi, Rintaro
AU  - Takahashi R
AUID- ORCID: 0000-0003-2168-9436
AD  - Department of Energy Engineering, Graduate School of Engineering, Nagoya 
      University, Furo-cho, Chikusa-ku, Nagoya, Aichi 464-8603, Japan.
FAU - Hamaguchi, Tasuku
AU  - Hamaguchi T
AD  - Institute of Multidisciplinary Research for Advanced Materials, Tohoku 
      University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
FAU - Jinnai, Hiroshi
AU  - Jinnai H
AUID- ORCID: 0000-0003-3400-1928
AD  - Institute of Multidisciplinary Research for Advanced Materials, Tohoku 
      University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan.
FAU - Yusa, Shin-Ichi
AU  - Yusa SI
AUID- ORCID: 0000-0002-2838-5200
AD  - Department of Applied Chemistry, Graduate School of Engineering, University of 
      Hyogo, 2167 Shosha, Himeji, Hyogo 671-2280, Japan.
LA  - eng
PT  - Journal Article
DEP - 20231110
PL  - United States
TA  - Langmuir
JT  - Langmuir : the ACS journal of surfaces and colloids
JID - 9882736
SB  - IM
EDAT- 2023/11/10 12:45
MHDA- 2023/11/10 12:46
CRDT- 2023/11/10 10:33
PHST- 2023/11/10 12:46 [medline]
PHST- 2023/11/10 12:45 [pubmed]
PHST- 2023/11/10 10:33 [entrez]
AID - 10.1021/acs.langmuir.3c02404 [doi]
PST - ppublish
SO  - Langmuir. 2023 Nov 21;39(46):16484-16493. doi: 10.1021/acs.langmuir.3c02404. Epub 
      2023 Nov 10.