PMID- 37947914
OWN - NLM
STAT- MEDLINE
DCOM- 20240304
LR  - 20240304
IS  - 1568-5608 (Electronic)
IS  - 0925-4692 (Linking)
VI  - 32
IP  - 1
DP  - 2024 Feb
TI  - Dietary tannic acid attenuates elastase-induced pulmonary inflammation and 
      emphysema in mice.
PG  - 747-761
LID - 10.1007/s10787-023-01381-z [doi]
AB  - Emphysema is one of the major components of chronic obstructive pulmonary disease 
      (COPD), which is characterised by the destruction and enlargement of air spaces, 
      leading to airflow limitation and dyspnoea, finally progressing to oxygen 
      dependency. The alveolar wall destruction is due to chronic inflammation, 
      oxidative stress, apoptosis, and proteinase/anti-proteinase imbalance. So far, 
      there has been no effective therapy for patients with COPD. We evaluated the 
      therapeutic efficacy of tannic acid (TA), a naturally occurring plant-derived 
      polyphenol in the murine emphysema model. In C57BL/6 J mice, we established 
      emphysema by intratracheal instillation of elastase (EL). Then, mice were treated 
      with TA and evaluated 1 and 21 days post-EL instillation. After 24 h, TA 
      treatment significantly reduced EL-induced histopathological alterations, 
      infiltrating leukocytes, and gene expression of markers of inflammation and 
      apoptosis. Similarly, after 21 days, TA treatment suppressed the mean linear 
      intercept, gene expression of proteinases, and increased elastic fiber contents 
      in the lungs when compared to the EL-alone group. Furthermore, EL induced the 
      activation of p38 mitogen-activated protein kinase (MAPK) and nuclear factor 
      kappa light chain enhancer of activated B cells (NF-kB) p65 pathways in the lungs 
      was suppressed by TA treatment. In summary, TA has the potential to mitigate 
      EL-induced inflammation, apoptosis, proteinase/anti-proteinase imbalance, and 
      subsequent emphysema in mice.
CI  - (c) 2023. The Author(s), under exclusive licence to Springer Nature Switzerland AG.
FAU - Rajasekar, Nandhine
AU  - Rajasekar N
AD  - Department of Biotechnology, BIT-Campus, Anna University, Tiruchirappalli, Tamil 
      Nadu 620024, India.
AD  - Wellman Center for Photomedicine, Massachusetts General Hospital, Harvard Medical 
      School, Boston, MA, 02114, USA.
FAU - Gandhi, Deepa
AU  - Gandhi D
AD  - Division of Biochemistry, ICMR-National Institute for Research in Environmental 
      Health, Bhopal, Madhya Pradesh, 462030, India.
FAU - Sivanantham, Ayyanar
AU  - Sivanantham A
AD  - Department of Biotechnology, BIT-Campus, Anna University, Tiruchirappalli, Tamil 
      Nadu 620024, India.
AD  - Division of Pulmonary and Critical Care Medicine, Department of Medicine, Boston 
      University, Boston, MA, 02118, USA.
FAU - Ravikumar, Vilwanathan
AU  - Ravikumar V
AD  - Department of Biochemistry, School of Life Sciences, Bharathidasan University, 
      Tiruchirappalli, Tamil Nadu 620024, India.
FAU - Raj, Dharma
AU  - Raj D
AD  - Division of Biostatistics and Bioinformatics, ICMR-National Institute for 
      Research in Environmental Health, Bhopal, Madhya Pradesh 462030, India.
FAU - Paramasivam, Sudhakar Gandhi
AU  - Paramasivam SG
AD  - Department of Biotechnology, BIT-Campus, Anna University, Tiruchirappalli, Tamil 
      Nadu 620024, India.
FAU - Mukhopadhyay, Sramana
AU  - Mukhopadhyay S
AD  - Department of Pathology and Lab Medicine, All India Institute of Medical 
      Sciences, Bhopal, Madhya Pradesh 462026, India.
FAU - Rajasekaran, Subbiah
AU  - Rajasekaran S
AUID- ORCID: 0000-0003-2303-3246
AD  - Division of Biochemistry, ICMR-National Institute for Research in Environmental 
      Health, Bhopal, Madhya Pradesh, 462030, India. rajasekaran.s@icmr.gov.in.
LA  - eng
GR  - BT/RLF/Re-entry/36/2013/Department of Biotechnology, Ministry of Science and 
      Technology, India/
PT  - Journal Article
DEP - 20231110
PL  - Switzerland
TA  - Inflammopharmacology
JT  - Inflammopharmacology
JID - 9112626
RN  - EC 3.4.21.36 (Pancreatic Elastase)
RN  - 0 (Tannic Acid)
RN  - EC 3.4.- (Peptide Hydrolases)
RN  - 0 (Polyphenols)
SB  - IM
MH  - Humans
MH  - Animals
MH  - Mice
MH  - Mice, Inbred C57BL
MH  - Pancreatic Elastase
MH  - *Emphysema
MH  - *Pneumonia/chemically induced/drug therapy
MH  - Inflammation/drug therapy
MH  - *Pulmonary Disease, Chronic Obstructive/chemically induced/drug therapy
MH  - Peptide Hydrolases
MH  - *Polyphenols
OTO - NOTNLM
OT  - Elastase
OT  - Emphysema
OT  - Inflammation
OT  - Natural compound
OT  - Tannic acid
OT  - Therapeutic effect
EDAT- 2023/11/10 12:45
MHDA- 2024/03/04 06:49
CRDT- 2023/11/10 11:08
PHST- 2023/09/07 00:00 [received]
PHST- 2023/10/13 00:00 [accepted]
PHST- 2024/03/04 06:49 [medline]
PHST- 2023/11/10 12:45 [pubmed]
PHST- 2023/11/10 11:08 [entrez]
AID - 10.1007/s10787-023-01381-z [pii]
AID - 10.1007/s10787-023-01381-z [doi]
PST - ppublish
SO  - Inflammopharmacology. 2024 Feb;32(1):747-761. doi: 10.1007/s10787-023-01381-z. 
      Epub 2023 Nov 10.