PMID- 37948484
OWN - NLM
STAT- MEDLINE
DCOM- 20231113
LR  - 20231113
IS  - 1433-6510 (Print)
IS  - 1433-6510 (Linking)
VI  - 69
IP  - 11
DP  - 2023 Nov 1
TI  - Lipocalin-2 Levels, Insulin Resistance, and Urinary Albumin Excretion in Type 2 
      Diabetes Subgroups.
LID - 10.7754/Clin.Lab.2023.230516 [doi]
AB  - BACKGROUND: Lipocalin-2 (LCN2) level in type 2 diabetes mellitus (T2DM) subgroups 
      has not been investigated. The aim of this study was to investigate LCN2 levels, 
      insulin resistance, urinary albumin excretion, and inflammation status in T2DM 
      subgroups. METHODS: A total of 251 patients with newly diagnosed T2DM were 
      evaluated. LCN2, glycated hemoglobin (HbA1c), FPG, tumor necrosis factor-alpha 
      (TNF-alpha), interleukin-6 (IL-6), and high-sensitivity C-reactive protein (hsCRP) 
      levels were measured. Patients with diabetes were categorized into three 
      subgroups: patients diagnosed with fasting plasma glucose (FPG) alone (FPG-DM), 
      those with isolated hemoglobin A1c (HbA1c) diabetes (A1c-DM), and those who met 
      the criteria for both FPG and HbA1c (FPG/A1c-DM). The albumin-to-creatinine ratio 
      (ACR), estimated glomerular filtration rate (eGFR), homeostasis model assessment 
      of insulin resistance (HOMA-IR), and adjusted LCN2 values, such as the 
      LCN2/inflammation index (LCN2/Inf) and LCN2/creatinine (LCN2/ Cr), were 
      calculated. RESULTS: The ACR, HOMA-IR, and glycosuria prevalence were 
      significantly higher in FPG-DM than in A1c-DM. In contrast, no significant 
      difference was observed in LCN2, eGFR, and proinflammatory cytokine levels 
      between the two groups. Patients with FPG/A1c-DM had significantly higher LCN2, 
      TNF-alpha, IL-6, and hsCRP levels than those with A1c-DM or FPG-DM. The percent 
      difference between LCN2 and LCN2/Inf was 3.2-fold greater than that between LCN2 
      and LCN2/Cr in FPG/A1c-DM. The presence of FPG-DM led to a 1.8-fold increase in 
      the prevalence of proteinuria (odds ratio, 1.876; 95% CI, 1.014 - 3.295; p < 
      0.001). The ability of FPG to identify proteinuria outperformed that of HbA1c 
      (area under the curve: 0.629, 95% CI, 0.553 - 0.706 versus 0.522, 95% CI, 0.436 - 
      0.605, p < 0.001). CONCLUSIONS: LCN2 elevation may be more largely due to 
      inflammation than kidney function, particularly in FPG/A1c-DM. Patients with 
      FPG-DM may be at a greater risk of diabetic nephropathy and insulin resistance 
      than those with A1c-DM.
FAU - Moon, Yeonsook
AU  - Moon Y
FAU - Lee, Moon Hee
AU  - Lee MH
FAU - Fujii, Noriyoshi
AU  - Fujii N
FAU - Fujii, Tatsuyoshi
AU  - Fujii T
FAU - Choi, Jong Weon
AU  - Choi JW
LA  - eng
PT  - Journal Article
PL  - Germany
TA  - Clin Lab
JT  - Clinical laboratory
JID - 9705611
RN  - 0 (Glycated Hemoglobin)
RN  - 0 (Blood Glucose)
RN  - 9007-41-4 (C-Reactive Protein)
RN  - 0 (Interleukin-6)
RN  - 0 (Tumor Necrosis Factor-alpha)
RN  - AYI8EX34EU (Creatinine)
RN  - 0 (Lipocalin-2)
RN  - 0 (Albumins)
SB  - IM
MH  - Humans
MH  - *Diabetes Mellitus, Type 2/diagnosis
MH  - Glycated Hemoglobin
MH  - *Insulin Resistance
MH  - Blood Glucose/metabolism
MH  - C-Reactive Protein/metabolism
MH  - Interleukin-6/metabolism
MH  - Tumor Necrosis Factor-alpha/metabolism
MH  - Creatinine
MH  - Lipocalin-2
MH  - Albumins
MH  - Proteinuria
MH  - Inflammation
EDAT- 2023/11/10 18:43
MHDA- 2023/11/13 06:42
CRDT- 2023/11/10 13:51
PHST- 2023/11/13 06:42 [medline]
PHST- 2023/11/10 18:43 [pubmed]
PHST- 2023/11/10 13:51 [entrez]
AID - 10.7754/Clin.Lab.2023.230516 [doi]
PST - ppublish
SO  - Clin Lab. 2023 Nov 1;69(11). doi: 10.7754/Clin.Lab.2023.230516.