PMID- 37949129
OWN - NLM
STAT- MEDLINE
DCOM- 20231127
LR  - 20231127
IS  - 1879-1026 (Electronic)
IS  - 0048-9697 (Linking)
VI  - 908
DP  - 2024 Jan 15
TI  - Microplastics aggravate the bioaccumulation and corresponding food safety risk of 
      antibiotics in edible bivalves by constraining detoxification-related processes.
PG  - 168436
LID - S0048-9697(23)07064-X [pii]
LID - 10.1016/j.scitotenv.2023.168436 [doi]
AB  - Characterized by a sessile filter-feeding lifestyle, commercial marine bivalves 
      inhabiting pollution-prone coastal areas may accumulate significant amounts of 
      pollutants, such as antibiotic residues, in their soft tissues and thus pose a 
      potential threat to the health of seafood consumers. Microplastics are another 
      type of emerging pollutant that are prevalent in coastal areas and have been 
      reported to interact with common antibiotics such as enrofloxacin (ENR) and 
      trimethoprim (TMP). Nevertheless, little is known about the impacts of MPs on the 
      accumulation and corresponding food safety risk of antibiotics in edible bivalve 
      species. Taking the frequently detected ENR, TMP, and polystyrene (PS)-MPs as 
      representatives, the accumulation of above-mentioned antibiotics in three 
      commercial bivalves with or without the copresence of MPs was assessed. In 
      addition, the corresponding food safety risks of consuming 
      antibiotic-contaminated bivalves were evaluated. Moreover, the impacts of these 
      pollutants on detoxification-related processes were analyzed using the 
      thick-shell mussel as a representative. Our results demonstrated that blood clams 
      (Tegillarca granosa), thick-shell mussels (Mytilus coruscus), and Asiatic hard 
      clams (Meretrix meretrix) accumulated significantly higher amounts of antibiotics 
      in their bodies under antibiotic-MP coexposure scenarios. Although based on the 
      target hazard quotients (THQs) and the margins of exposure (MoEs) obtained, the 
      direct toxic risks of consuming ENR- or TMP-contaminated bivalves were 
      negligible, the TMP residue accumulated in TMP-MP-coexposed mussels did surpass 
      the maximum residue limits (MRLs) of the corresponding National Food Safety 
      Standard of China, suggesting that other forms of potential risks should not be 
      ignored. In addition, it was shown that the detoxification, energy provision, and 
      antioxidant capacities of the thick-shell mussels were significantly hampered by 
      exposure to the pollutants. In general, our data indicate that MPs may aggravate 
      the accumulation and corresponding food safety risk of antibiotics in edible 
      bivalves by disrupting detoxification-related processes, which deserves closer 
      attention.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Yu, Yihan
AU  - Yu Y
AD  - College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
FAU - Tian, Dandan
AU  - Tian D
AD  - College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
FAU - Yu, Yingying
AU  - Yu Y
AD  - College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
FAU - Lu, Lingzheng
AU  - Lu L
AD  - College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
FAU - Shi, Wei
AU  - Shi W
AD  - College of Animal Sciences, Zhejiang University, Hangzhou, PR China.
FAU - Liu, Guangxu
AU  - Liu G
AD  - College of Animal Sciences, Zhejiang University, Hangzhou, PR China. Electronic 
      address: guangxu_liu@zju.edu.cn.
LA  - eng
PT  - Journal Article
DEP - 20231108
PL  - Netherlands
TA  - Sci Total Environ
JT  - The Science of the total environment
JID - 0330500
RN  - 0 (Microplastics)
RN  - 0 (Plastics)
RN  - 0 (Anti-Bacterial Agents)
RN  - AN164J8Y0X (Trimethoprim)
RN  - 0 (Environmental Pollutants)
RN  - 0 (Water Pollutants, Chemical)
SB  - IM
MH  - Animals
MH  - Microplastics
MH  - Plastics
MH  - Anti-Bacterial Agents/adverse effects
MH  - Bioaccumulation
MH  - *Mytilus/chemistry
MH  - Food Safety
MH  - *Arcidae
MH  - Trimethoprim
MH  - *Environmental Pollutants
MH  - *Water Pollutants, Chemical/analysis
OTO - NOTNLM
OT  - Accumulation
OT  - Enrofloxacin
OT  - Food safety
OT  - Marine bivalves
OT  - Microplastics
OT  - Trimethoprim
COIS- Declaration of competing interest The authors declare no competing interests.
EDAT- 2023/11/11 11:44
MHDA- 2023/11/27 12:42
CRDT- 2023/11/10 19:13
PHST- 2023/08/25 00:00 [received]
PHST- 2023/10/19 00:00 [revised]
PHST- 2023/11/07 00:00 [accepted]
PHST- 2023/11/27 12:42 [medline]
PHST- 2023/11/11 11:44 [pubmed]
PHST- 2023/11/10 19:13 [entrez]
AID - S0048-9697(23)07064-X [pii]
AID - 10.1016/j.scitotenv.2023.168436 [doi]
PST - ppublish
SO  - Sci Total Environ. 2024 Jan 15;908:168436. doi: 10.1016/j.scitotenv.2023.168436. 
      Epub 2023 Nov 8.