PMID- 37949241
OWN - NLM
STAT- MEDLINE
DCOM- 20231204
LR  - 20240129
IS  - 1573-2517 (Electronic)
IS  - 0165-0327 (Linking)
VI  - 346
DP  - 2024 Feb 1
TI  - Fatty acid intake and prevalence of depression among Brazilian graduates and 
      postgraduates (CUME Study).
PG  - 182-191
LID - S0165-0327(23)01372-1 [pii]
LID - 10.1016/j.jad.2023.11.012 [doi]
AB  - BACKGROUND: Dietary fatty acids are related to the development of several 
      inflammatory-related diseases, which may include depression. So, the association 
      between fatty acids, culinary oils and fat intake and depression in highly 
      educated Brazilians was evaluated. METHODS: Multicenter cross-sectional study 
      using baseline data from the Cohort of Universities of Minas Gerais. The 
      diagnosis of depression was self-reported, and the daily intake of fatty acids 
      was assessed using a 144-item food frequency questionnaire (FFQ). RESULTS: A 
      total of 7157 participants (68.83 % women) with a median age of 33 years were 
      included. The prevalence of depression was 12.60 % (N = 902). In the adjusted 
      analyses, it was observed that individuals with the highest intake of omega-6 
      fatty acids (n-6) (OR: 1.36, 95 % CI 1.11-1.67) had a higher prevalence of 
      depression. This increased n-6 intake was identified as a risk factor for 
      depression only among male participants, while among overweight participants, 
      higher n-6 intake was also positively associated with depression. Conversely, a 
      higher ratio of polyunsaturated to monounsaturated and saturated fatty acids 
      (PM/S) was also found to be positively associated with depression, but this 
      association was observed only among non-overweight participants. No associations 
      were found between the consumption of culinary oils or fats and depression. 
      LIMITATIONS: Cross-sectional design limits the assessment of causality. The use 
      of the FFQ can make estimates more difficult. CONCLUSION: Higher consumption of 
      n-6, and higher PM/S ratios were associated with depression, and individual 
      factors can interfere. The mental health care policies should include specific 
      nutritional strategies.
CI  - Copyright (c) 2023 Elsevier B.V. All rights reserved.
FAU - Sabiao, Thais da Silva
AU  - Sabiao TDS
AD  - Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil. Electronic 
      address: thaissabiao14@gmail.com.
FAU - Oliveira, Fatima Costa de
AU  - Oliveira FC
AD  - Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
FAU - Bressan, Josefina
AU  - Bressan J
AD  - Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil.
FAU - Pimenta, Adriano Marcal
AU  - Pimenta AM
AD  - Universidade Federal do Parana, Curitiba, Parana, Brazil.
FAU - Hermsdorff, Helen Hermana Miranda
AU  - Hermsdorff HHM
AD  - Universidade Federal de Vicosa, Vicosa, Minas Gerais, Brazil.
FAU - Oliveira, Fernando Luiz Pereira de
AU  - Oliveira FLP
AD  - Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
FAU - Mendonca, Raquel de Deus
AU  - Mendonca RD
AD  - Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
FAU - Carraro, Julia Cristina Cardoso
AU  - Carraro JCC
AD  - Universidade Federal de Ouro Preto, Ouro Preto, Minas Gerais, Brazil.
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20231108
PL  - Netherlands
TA  - J Affect Disord
JT  - Journal of affective disorders
JID - 7906073
RN  - 0 (Fatty Acids)
RN  - 0 (Oils)
RN  - 0 (Fatty Acids, Omega-3)
SB  - IM
MH  - Humans
MH  - Male
MH  - Female
MH  - Adult
MH  - *Fatty Acids
MH  - Cross-Sectional Studies
MH  - Depression/epidemiology
MH  - Prevalence
MH  - Brazil/epidemiology
MH  - Prospective Studies
MH  - Oils
MH  - *Fatty Acids, Omega-3
OTO - NOTNLM
OT  - Culinary oils
OT  - Depression
OT  - Fatty acids
OT  - Food consumption
OT  - Multicenter study
OT  - N-6
COIS- Declaration of competing interest The authors declare that they have no known 
      competing financial interests or personal relationships that could have appeared 
      to influence the work reported in this paper.
EDAT- 2023/11/11 11:42
MHDA- 2023/12/04 12:42
CRDT- 2023/11/10 19:15
PHST- 2023/01/18 00:00 [received]
PHST- 2023/11/03 00:00 [revised]
PHST- 2023/11/07 00:00 [accepted]
PHST- 2023/12/04 12:42 [medline]
PHST- 2023/11/11 11:42 [pubmed]
PHST- 2023/11/10 19:15 [entrez]
AID - S0165-0327(23)01372-1 [pii]
AID - 10.1016/j.jad.2023.11.012 [doi]
PST - ppublish
SO  - J Affect Disord. 2024 Feb 1;346:182-191. doi: 10.1016/j.jad.2023.11.012. Epub 
      2023 Nov 8.