PMID- 37949774
OWN - NLM
STAT- MEDLINE
DCOM- 20240427
LR  - 20240427
IS  - 1878-7541 (Electronic)
IS  - 1550-8307 (Linking)
VI  - 20
IP  - 3
DP  - 2024 May-Jun
TI  - Mindfulness-oriented recovery enhancement in opioid use disorder: Extended 
      emotional regulation and neural effects and immediate effects of guided 
      meditation in a pilot sample.
PG  - 434-438
LID - S1550-8307(23)00259-8 [pii]
LID - 10.1016/j.explore.2023.11.001 [doi]
AB  - OBJECTIVE: Mindfulness-Oriented Recovery Enhancement (MORE) is an efficacious 
      intervention to aid recovery from substance use disorder. This study in a pilot 
      sample of individuals in treatment for opioid use disorder (OUD) characterizes 
      longer-term changes after the MORE intervention and immediate effects of a brief 
      MORE guided meditation session. DESIGN: Twelve female participants in residential 
      treatment for OUD completed an 8-week MORE intervention. Participants completed 
      two sessions: one before and one after the 8-week MORE intervention. Each session 
      included an emotional regulation questionnaire outside an MRI scanner first and 
      then a 10-minute guided MORE meditation inside the scanner during which 
      functional magnetic resonance imaging (fMRI) data were collected. Emotional 
      regulation was measured after 8-weeks of MORE intervention. In addition, 
      functional connectivity (i.e. correlated fMRI signal) between regions in a 
      hypothesized affect regulation network was measured during the meditation state 
      to assess change in brain network function due to 8-weeks of MORE. For each 
      10-min guided meditation, we also assessed their mood and opioid craving. 
      RESULTS: Nine participants completed all measurements. Participants' emotional 
      regulation difficulty significantly decreased after 8-weeks of MORE intervention. 
      Furthermore, after 8-weeks of MORE, there was significantly increased 
      connectivity between left ventromedial prefrontal cortex and left amygdala and 
      between left ventrolateral prefrontal cortex and left nucleus accumbens captured 
      during a meditation state. In both sessions, positive mood significantly 
      increased after 10-min of guided mediation, however opioid craving was not 
      significantly influenced. CONCLUSIONS: This pilot study characterizes potential 
      benefits of 8-week MORE intervention in improving emotional regulation difficulty 
      and brain function. A 10-min guided MORE meditation may immediately improve mood, 
      with potential to reduce acute stress- or cue-provoked craving. These results 
      warrant future studies with larger sample size.
CI  - Copyright (c) 2023. Published by Elsevier Inc.
FAU - Ray, Suchismita
AU  - Ray S
AD  - Department of Health Informatics, Rutgers School of Health Professions, Rutgers 
      University, The State University of New Jersey, 65 Bergen Street, Newark, New 
      Jersey 07107, United States. Electronic address: shmita@rutgers.edu.
FAU - Bhanji, Jamil
AU  - Bhanji J
AD  - Department of Psychology, Rutgers University, Newark, New Jersey, United States.
FAU - Kennelly, Nicole
AU  - Kennelly N
AD  - Institute for Health, Health Care Policy and Aging Research, Rutgers University, 
      New Brunswick, New Jersey, United States.
FAU - Fox, Helen C
AU  - Fox HC
AD  - Stony Brook University, New York, United States.
FAU - Budsock, Patricia Dooley
AU  - Budsock PD
AD  - Addiction Psychiatry, Rutgers Robert Wood Johnson Medical School, Rutgers 
      University, Piscataway, New Jersey, United States.
FAU - Delgado, Mauricio
AU  - Delgado M
AD  - Department of Psychology, Rutgers University, Newark, New Jersey, United States.
FAU - Cooperman, Nina A
AU  - Cooperman NA
AD  - Addiction Psychiatry, Rutgers Robert Wood Johnson Medical School, Rutgers 
      University, Piscataway, New Jersey, United States.
FAU - Garland, Eric L
AU  - Garland EL
AD  - College of Social Work, University of Utah, Utah, United States.
LA  - eng
GR  - R01 DA056537/DA/NIDA NIH HHS/United States
GR  - R01 DA057631/DA/NIDA NIH HHS/United States
GR  - R01 DA058621/DA/NIDA NIH HHS/United States
GR  - R33 AT010109/AT/NCCIH NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20231102
PL  - United States
TA  - Explore (NY)
JT  - Explore (New York, N.Y.)
JID - 101233160
SB  - IM
MH  - Humans
MH  - *Mindfulness/methods
MH  - Female
MH  - *Meditation/methods/psychology
MH  - Adult
MH  - Pilot Projects
MH  - *Magnetic Resonance Imaging
MH  - *Emotional Regulation/physiology
MH  - *Opioid-Related Disorders/therapy/psychology
MH  - *Brain/physiopathology
MH  - Middle Aged
MH  - Craving/physiology
MH  - Affect
OTO - NOTNLM
OT  - Connectivity
OT  - Emotion
OT  - Mindfulness
OT  - Opioid use disorder
OT  - Women
OT  - fMRI
EDAT- 2023/11/11 11:42
MHDA- 2024/04/28 07:25
CRDT- 2023/11/10 21:59
PHST- 2023/08/03 00:00 [received]
PHST- 2023/10/29 00:00 [revised]
PHST- 2023/11/01 00:00 [accepted]
PHST- 2024/04/28 07:25 [medline]
PHST- 2023/11/11 11:42 [pubmed]
PHST- 2023/11/10 21:59 [entrez]
AID - S1550-8307(23)00259-8 [pii]
AID - 10.1016/j.explore.2023.11.001 [doi]
PST - ppublish
SO  - Explore (NY). 2024 May-Jun;20(3):434-438. doi: 10.1016/j.explore.2023.11.001. 
      Epub 2023 Nov 2.