PMID- 37951091 OWN - NLM STAT- MEDLINE DCOM- 20231121 LR - 20231121 IS - 1090-2414 (Electronic) IS - 0147-6513 (Linking) VI - 267 DP - 2023 Nov 15 TI - Effects of prenatal single and mixed bisphenol exposure on bone mineral density in preschool children: A population-based prospective cohort study. PG - 115665 LID - S0147-6513(23)01169-7 [pii] LID - 10.1016/j.ecoenv.2023.115665 [doi] AB - Exposure to bisphenols can affect bone mineral density (BMD) in animals and humans. However, the effects of maternal exposure to bisphenols during pregnancy on bone health in preschool children remain unknown. We aimed to assess the effects of prenatal exposure to single and multiple bisphenols on bone health in preschool children. A total of 230 mother-child pairs were included in this study. Generalized linear regression, restricted cubic spline (RCS), principal component analysis (PCA), and Bayesian kernel machine regression (BKMR) were utilized to assess the relationship between bisphenol levels and bone health in preschool children. Each natural log (Ln) unit increase in tetrabromobisphenol A was related to a 0.007 m/s (95 % CI: -0.015, 0.000) decrease in Ln-transformed speed of sound (SOS) among girls. Decreased BMD Z scores in preschool children were found only in the high bisphenol S exposure group (beta = -0.568; 95 % CI: -1.087, -0.050) in boys. The risk of low BMD (BMDL) was significantly higher in the middle-exposure group (OR = 4.695; 95 % CI: 1.143, 24.381) and high-exposure group of BPS (OR = 6.165, 95 % CI: 1.445, 33.789) compared with the low-exposure group in boys. In girls, the risk of BMDL decreased with increasing bisphenol A concentration (OR = 0.413, 95 % CI: 0.215, 0.721). RCS analysis revealed a U-shaped nonlinear correlation between BPB concentration and BMDL in girls (P-overall = 0.011, P-nonlinear = 0.009). In PCA, a U-shaped dose-response relationship was found between PC2 and the risk of BMDL (P-overall = 0.048, P-nonlinear = 0.032), and a significant association was only noted in girls when stratified by sex. The BKMR model revealed a horizontal S-shaped curve relationship between bisphenol mixtures and BMDL in girls. The results indicated that prenatal exposure to single and mixed bisphenols can affect BMD in preschool children, exerting nonmonotonic and child sex-specific effects. CI - Copyright (c) 2023 The Authors. Published by Elsevier Inc. All rights reserved. FAU - Liang, Jun AU - Liang J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Pang, Lixiang AU - Pang L AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Yang, Chunxiu AU - Yang C AD - The People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, Guangxi 530021, China. FAU - Long, Jinghua AU - Long J AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China; The First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Liao, Qian AU - Liao Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Tang, Peng AU - Tang P AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Huang, Huishen AU - Huang H AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Wei, Huanni AU - Wei H AD - Liuzhou People's Hospital Affiliated to Guangxi Medical University, Liuzhou 545006, China. FAU - Chen, Qian AU - Chen Q AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Yang, Kaiqi AU - Yang K AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Liu, Tao AU - Liu T AD - Huaihua Center for Disease Control and Prevention, Huaihua, Hunan 418000, China. FAU - Lv, Fangfang AU - Lv F AD - Department of Child and Adolescent Health & Maternal and Child Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Liu, Shun AU - Liu S AD - Department of Child and Adolescent Health & Maternal and Child Health, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. FAU - Huang, Dongping AU - Huang D AD - Department of Sanitary Chemistry, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: dongpinghuang@gxmu.edu.cn. FAU - Qiu, Xiaoqiang AU - Qiu X AD - Department of Epidemiology and Health Statistics, School of Public Health, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: xqqiu9999@163.com. LA - eng PT - Journal Article DEP - 20231110 PL - Netherlands TA - Ecotoxicol Environ Saf JT - Ecotoxicology and environmental safety JID - 7805381 RN - MLT3645I99 (bisphenol A) SB - IM MH - Animals MH - Male MH - Female MH - Pregnancy MH - Humans MH - Child, Preschool MH - *Bone Density MH - Bayes Theorem MH - *Prenatal Exposure Delayed Effects MH - Prospective Studies OTO - NOTNLM OT - Bisphenol OT - Bone mineral density OT - Pregnant women OT - Preschool children COIS- Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper. EDAT- 2023/11/12 00:42 MHDA- 2023/11/21 06:42 CRDT- 2023/11/11 18:12 PHST- 2023/08/06 00:00 [received] PHST- 2023/10/22 00:00 [revised] PHST- 2023/11/03 00:00 [accepted] PHST- 2023/11/21 06:42 [medline] PHST- 2023/11/12 00:42 [pubmed] PHST- 2023/11/11 18:12 [entrez] AID - S0147-6513(23)01169-7 [pii] AID - 10.1016/j.ecoenv.2023.115665 [doi] PST - ppublish SO - Ecotoxicol Environ Saf. 2023 Nov 15;267:115665. doi: 10.1016/j.ecoenv.2023.115665. Epub 2023 Nov 10.